Metascintillators: New Results for TOF-PET Applications

We report on the progress on a first generation of realistic size metascintillators for time-of-flight PET. These heterostructures combine dense LYSO or BGO plates, interleaved with fast scintillator layers producing a bunch of prompt photons from the energy leakage of the recoil photoelectric elect...

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Autores: Lecoq, P., Konstantinou, Georgios, Latella, Riccardo, Moliner, Laura, Nuyts, Johan, Zhang, Lei, Barrio Toala, J., Benlloch Baviera, José María, González Martínez, Antonio Javier
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420037
Acceso en línea:http://hdl.handle.net/10261/420037
https://api.elsevier.com/content/abstract/scopus_id/85127068570
Access Level:acceso abierto
Palabra clave:Scintillators
Geometry
Timing
Signal to noise ratio
Crystals
Image reconstruction
Sensitivity
Heterostructure
Metascintillator
Positron emission tomography (PET)
Time of flight (TOF)
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spelling Metascintillators: New Results for TOF-PET ApplicationsLecoq, P.Konstantinou, GeorgiosLatella, RiccardoMoliner, LauraNuyts, JohanZhang, LeiBarrio Toala, J.Benlloch Baviera, José MaríaGonzález Martínez, Antonio JavierScintillatorsGeometryTimingSignal to noise ratioCrystalsImage reconstructionSensitivityHeterostructureMetascintillatorPositron emission tomography (PET)ScintillatorsTime of flight (TOF)We report on the progress on a first generation of realistic size metascintillators for time-of-flight PET. These heterostructures combine dense LYSO or BGO plates, interleaved with fast scintillator layers producing a bunch of prompt photons from the energy leakage of the recoil photoelectric electron. From a Geant4 simulation of the energy sharing distribution between the dense and the fast scintillator on 42 LYSO-based and 42 BGO-based configurations, a detailed study of the timing performance has been performed on a selection of the most promising 12 LYSO-based and 14 BGO-based metascintillators. A Monte Carlo simulation was first performed to extrapolate from direct measurements of the performance of the metascintillator components, the detector time resolution (DTR), and sensitivity on the basis of the simulated amount of energy leakage to the fast scintillator. An analytic algorithm was then applied to determine an equivalent coincidence time resolution (CTR) from the random association of the DTR distributions from two metapixels in coincidence. This equivalent CTR is calculated in order to obtain the same variance in the reconstructed image as the combination of the DTR distributions of 2 metapixels. Preliminary results confirm that with these simple and still nonoptimized configurations, an equivalent CTR of 150 ps for BGO-based and 140 ps for LYSO-based metapixels of realistic size can be obtained.This work was supported in part by the European Research Council (ERC) through the European Union’s Horizon 2020 Research and Innovation Programme under Grant 695536. The work of P. Lecoq was supported in part by ERC Advanced under Grant TICAL 338953, and in part by the related Proof-ofConcept Project under Grant ULTIMA 680552, both funded by the European Commission. (Corresponding author: P. Lecoq.)Peer reviewedInstitute of Electrical and Electronics EngineersEuropean CommissionLecoq, P. [0000-0002-3198-0115]Konstantinou, Georgios [0000-0002-1005-282X]Latella, Riccardo [0000-0002-5044-9557]Moliner, Laura [0000-0003-2782-5902]Nuyts, Johan [0000-0003-1923-6198]Zhang, Lei [0000-0001-8414-6645]Barrio Toala, J. [0000-0001-5181-2146]Benlloch Baviera, José María [0000-0001-6073-1436]González Martínez, Antonio Javier [0000-0001-6742-5626]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/420037https://api.elsevier.com/content/abstract/scopus_id/85127068570reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/695536info:eu-repo/grantAgreement/EC/H2020/338953info:eu-repo/grantAgreement/EC/H2020/680552https://doi.org/10.1109/TRPMS.2022.3161473Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4200372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Metascintillators: New Results for TOF-PET Applications
title Metascintillators: New Results for TOF-PET Applications
spellingShingle Metascintillators: New Results for TOF-PET Applications
Lecoq, P.
Scintillators
Geometry
Timing
Signal to noise ratio
Crystals
Image reconstruction
Sensitivity
Heterostructure
Metascintillator
Positron emission tomography (PET)
Scintillators
Time of flight (TOF)
title_short Metascintillators: New Results for TOF-PET Applications
title_full Metascintillators: New Results for TOF-PET Applications
title_fullStr Metascintillators: New Results for TOF-PET Applications
title_full_unstemmed Metascintillators: New Results for TOF-PET Applications
title_sort Metascintillators: New Results for TOF-PET Applications
dc.creator.none.fl_str_mv Lecoq, P.
Konstantinou, Georgios
Latella, Riccardo
Moliner, Laura
Nuyts, Johan
Zhang, Lei
Barrio Toala, J.
Benlloch Baviera, José María
González Martínez, Antonio Javier
author Lecoq, P.
author_facet Lecoq, P.
Konstantinou, Georgios
Latella, Riccardo
Moliner, Laura
Nuyts, Johan
Zhang, Lei
Barrio Toala, J.
Benlloch Baviera, José María
González Martínez, Antonio Javier
author_role author
author2 Konstantinou, Georgios
Latella, Riccardo
Moliner, Laura
Nuyts, Johan
Zhang, Lei
Barrio Toala, J.
Benlloch Baviera, José María
González Martínez, Antonio Javier
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Lecoq, P. [0000-0002-3198-0115]
Konstantinou, Georgios [0000-0002-1005-282X]
Latella, Riccardo [0000-0002-5044-9557]
Moliner, Laura [0000-0003-2782-5902]
Nuyts, Johan [0000-0003-1923-6198]
Zhang, Lei [0000-0001-8414-6645]
Barrio Toala, J. [0000-0001-5181-2146]
Benlloch Baviera, José María [0000-0001-6073-1436]
González Martínez, Antonio Javier [0000-0001-6742-5626]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Scintillators
Geometry
Timing
Signal to noise ratio
Crystals
Image reconstruction
Sensitivity
Heterostructure
Metascintillator
Positron emission tomography (PET)
Scintillators
Time of flight (TOF)
topic Scintillators
Geometry
Timing
Signal to noise ratio
Crystals
Image reconstruction
Sensitivity
Heterostructure
Metascintillator
Positron emission tomography (PET)
Scintillators
Time of flight (TOF)
description We report on the progress on a first generation of realistic size metascintillators for time-of-flight PET. These heterostructures combine dense LYSO or BGO plates, interleaved with fast scintillator layers producing a bunch of prompt photons from the energy leakage of the recoil photoelectric electron. From a Geant4 simulation of the energy sharing distribution between the dense and the fast scintillator on 42 LYSO-based and 42 BGO-based configurations, a detailed study of the timing performance has been performed on a selection of the most promising 12 LYSO-based and 14 BGO-based metascintillators. A Monte Carlo simulation was first performed to extrapolate from direct measurements of the performance of the metascintillator components, the detector time resolution (DTR), and sensitivity on the basis of the simulated amount of energy leakage to the fast scintillator. An analytic algorithm was then applied to determine an equivalent coincidence time resolution (CTR) from the random association of the DTR distributions from two metapixels in coincidence. This equivalent CTR is calculated in order to obtain the same variance in the reconstructed image as the combination of the DTR distributions of 2 metapixels. Preliminary results confirm that with these simple and still nonoptimized configurations, an equivalent CTR of 150 ps for BGO-based and 140 ps for LYSO-based metapixels of realistic size can be obtained.
publishDate 2022
dc.date.none.fl_str_mv 2022
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/420037
https://api.elsevier.com/content/abstract/scopus_id/85127068570
url http://hdl.handle.net/10261/420037
https://api.elsevier.com/content/abstract/scopus_id/85127068570
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/695536
info:eu-repo/grantAgreement/EC/H2020/338953
info:eu-repo/grantAgreement/EC/H2020/680552
https://doi.org/10.1109/TRPMS.2022.3161473
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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