Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics

Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA mod...

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Detalles Bibliográficos
Autores: Janin, Maxime, Esteller, Manel, Davalos, Veronica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/220171
Acceso en línea:https://hdl.handle.net/2445/220171
Access Level:acceso abierto
Palabra clave:Tumors
Metàstasi
Metilació
Epigenètica
Metastasis
Methylation
Epigenetics
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spelling Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomicsJanin, MaximeEsteller, ManelDavalos, VeronicaTumorsMetàstasiMetilacióEpigenèticaTumorsMetastasisMethylationEpigeneticsMost of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA modifiers, namely writers, readers, and erasers; enzymes responsible of respectively introducing, recognizing, or removing the epigenetic or epitranscriptomic modifications. Epigenetic regulation is achieved by DNA methylation, histone modifications, non-coding RNAs, chromatin accessibility, and enhancer reprogramming. In parallel, regulation at RNA level, named epitranscriptomic, is driven by a wide diversity of chemical modifications in mostly all RNA molecules. These two-layer regulatory mechanisms are finely controlled in normal tissue, and dysregulations are associated with every hallmark of human cancer. In this review, we provide an overview of the current state of knowledge regarding epigenetic and epitranscriptomic alterations governing tumor metastasis, and compare pathways regulated at DNA or RNA levels to shed light on a possible epi-crosstalk in cancer metastasis. A deeper understanding on these mechanisms could have important clinical implications for the prevention of advanced malignancies and the management of the disseminated diseases. Additionally, as these epi-alterations can potentially be reversed by small molecules or inhibitors against epi-modifiers, novel therapeutic alternatives could be envisioned.Springer Science + Business Media2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion42 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/220171Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s10555-023-10120-3Cancer and Metastasis Reviews, 2023, vol. 42, p. 1071-1112https://doi.org/10.1007/s10555-023-10120-3cc by (c) Janin, Maxime et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2201712026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
title Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
spellingShingle Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
Janin, Maxime
Tumors
Metàstasi
Metilació
Epigenètica
Tumors
Metastasis
Methylation
Epigenetics
title_short Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
title_full Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
title_fullStr Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
title_full_unstemmed Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
title_sort Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
dc.creator.none.fl_str_mv Janin, Maxime
Esteller, Manel
Davalos, Veronica
author Janin, Maxime
author_facet Janin, Maxime
Esteller, Manel
Davalos, Veronica
author_role author
author2 Esteller, Manel
Davalos, Veronica
author2_role author
author
dc.subject.none.fl_str_mv Tumors
Metàstasi
Metilació
Epigenètica
Tumors
Metastasis
Methylation
Epigenetics
topic Tumors
Metàstasi
Metilació
Epigenètica
Tumors
Metastasis
Methylation
Epigenetics
description Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA modifiers, namely writers, readers, and erasers; enzymes responsible of respectively introducing, recognizing, or removing the epigenetic or epitranscriptomic modifications. Epigenetic regulation is achieved by DNA methylation, histone modifications, non-coding RNAs, chromatin accessibility, and enhancer reprogramming. In parallel, regulation at RNA level, named epitranscriptomic, is driven by a wide diversity of chemical modifications in mostly all RNA molecules. These two-layer regulatory mechanisms are finely controlled in normal tissue, and dysregulations are associated with every hallmark of human cancer. In this review, we provide an overview of the current state of knowledge regarding epigenetic and epitranscriptomic alterations governing tumor metastasis, and compare pathways regulated at DNA or RNA levels to shed light on a possible epi-crosstalk in cancer metastasis. A deeper understanding on these mechanisms could have important clinical implications for the prevention of advanced malignancies and the management of the disseminated diseases. Additionally, as these epi-alterations can potentially be reversed by small molecules or inhibitors against epi-modifiers, novel therapeutic alternatives could be envisioned.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220171
url https://hdl.handle.net/2445/220171
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s10555-023-10120-3
Cancer and Metastasis Reviews, 2023, vol. 42, p. 1071-1112
https://doi.org/10.1007/s10555-023-10120-3
dc.rights.none.fl_str_mv cc by (c) Janin, Maxime et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Janin, Maxime et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 42 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Science + Business Media
publisher.none.fl_str_mv Springer Science + Business Media
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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