Personalized pulmonary vein antrum isolation guided by left atrial wall thickness for persistent atrial fibrillation

Aims: Pulmonary vein (PV) antrum isolation proved to be effective for treating persistent atrial fibrillation (PeAF). We sought to investigate the results of a personalized approach aimed at adapting the ablation index (AI) to the local left atrial wall thickness (LAWT) in a cohort of consecutive pa...

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Detalles Bibliográficos
Autores: Falasconi, Giulio, Penela, Diego, Soto-Iglesias, David, Francia, Pietro, Teres, Cheryl, Saglietto, Andrea, Jauregui, Beatriz, Viveros, Daniel, Bellido, Aldo, Alderete, Jose, Meca-Santamaria, Julia, Franco Ocaña, Paula, Gaspardone, Carlo, San Antonio, Rodolfo, Huguet, Marina, Camara, Oscar, Ortiz-Pérez, Jose-Tomás, Martí-Almor, Julio, Berruezo Sánchez, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/57421
Acceso en línea:http://hdl.handle.net/10230/57421
http://dx.doi.org/10.1093/europace/euad118
Access Level:acceso abierto
Palabra clave:Persistent atrial fibrillation
Left atrial wall thickness
Catheter ablation
Pulmonary vein isolation
Multidetector cardiac tomography
Descripción
Sumario:Aims: Pulmonary vein (PV) antrum isolation proved to be effective for treating persistent atrial fibrillation (PeAF). We sought to investigate the results of a personalized approach aimed at adapting the ablation index (AI) to the local left atrial wall thickness (LAWT) in a cohort of consecutive patients with PeAF. Methods and results: Consecutive patients referred for PeAF first ablation were prospectively enrolled. The LAWT three-dimensional maps were obtained from pre-procedure multidetector computed tomography and integrated into the navigation system. Ablation index was titrated according to the local LAWT, and the ablation line was personalized to avoid the thickest regions while encircling the PV antrum. A total of 121 patients (69.4% male, age 64.5 ± 9.5 years) were included. Procedure time was 57 min (IQR 50–67), fluoroscopy time was 43 s (IQR 20–71), and radiofrequency (RF) time was 16.5 min (IQR 14.3–18.4). The median AI tailored to the local LAWT was 387 (IQR 360–410) for the anterior wall and 335 (IQR 300–375) for the posterior wall. First-pass PV antrum isolation was obtained in 103 (85%) of the right PVs and 103 (85%) of the left PVs. Median LAWT values were higher for PVs without first-pass isolation as compared to the whole cohort (P = 0.02 for left PVs and P = 0.03 for right PVs). Recurrence-free survival was 79% at 12 month follow-up. Conclusion: In this prospective study, LAWT-guided PV antrum isolation for PeAF was effective and efficient, requiring low procedure, fluoroscopy, and RF time. A randomized trial comparing the LAWT-guided ablation with the standard of practice is in progress (ClinicalTrials.gov, NCT05396534).

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