Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1

7 páginas, 5 figuras

Detalhes bibliográficos
Autores: Gay, Frédérique, Calvo, Dominica, Lo, Miao-Chia, Cerón, Julián, Maduro, Morris, Lin, Rueyling, Shi, Yang
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/415656
Acesso em linha:http://hdl.handle.net/10261/415656
Access Level:acceso abierto
Palavra-chave:POP-1
LEF/TCF
Wnt
CBP-1
Acetylation
C. elegans
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spelling Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1Gay, FrédériqueCalvo, DominicaLo, Miao-ChiaCerón, JuliánMaduro, MorrisLin, RueylingShi, YangPOP-1LEF/TCFWntCBP-1AcetylationC. elegans7 páginas, 5 figurasLymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that mediate the Wnt signaling pathway, and have crucial roles during embryonic development in various organisms. Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export. We identify three lysines that are acetylated in vivo, and demonstrate their essential requirement for proper nuclear localization and biological activity of POP-1 during C. elegans embryogenesis. The conservation of these lysines among other LEF/TCF family members suggests that acetylation may be an important, evolutionarily conserved mechanism regulating subcellular distribution of LEF/TCF factors.F.G. was supported by a fellowship from the Lalor Foundation, and from the Taplin Funds for Discovery. This work was supported by grants from the National Institutes of Health (GM58012, GM53874) to Y.S. The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.Peer reviewedCold Spring Harbor Laboratory PressLalor FoundationTaplin FellowshipsNational Institutes of Health (US)Cerón, Julián [0000-0003-4739-2243]202620262003info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/415656reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1101/gad.1042403Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4156562026-05-22T06:33:51Z
dc.title.none.fl_str_mv Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
title Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
spellingShingle Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
Gay, Frédérique
POP-1
LEF/TCF
Wnt
CBP-1
Acetylation
C. elegans
title_short Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
title_full Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
title_fullStr Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
title_full_unstemmed Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
title_sort Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
dc.creator.none.fl_str_mv Gay, Frédérique
Calvo, Dominica
Lo, Miao-Chia
Cerón, Julián
Maduro, Morris
Lin, Rueyling
Shi, Yang
author Gay, Frédérique
author_facet Gay, Frédérique
Calvo, Dominica
Lo, Miao-Chia
Cerón, Julián
Maduro, Morris
Lin, Rueyling
Shi, Yang
author_role author
author2 Calvo, Dominica
Lo, Miao-Chia
Cerón, Julián
Maduro, Morris
Lin, Rueyling
Shi, Yang
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Lalor Foundation
Taplin Fellowships
National Institutes of Health (US)
Cerón, Julián [0000-0003-4739-2243]
dc.subject.none.fl_str_mv POP-1
LEF/TCF
Wnt
CBP-1
Acetylation
C. elegans
topic POP-1
LEF/TCF
Wnt
CBP-1
Acetylation
C. elegans
description 7 páginas, 5 figuras
publishDate 2003
dc.date.none.fl_str_mv 2003
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/415656
url http://hdl.handle.net/10261/415656
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1101/gad.1042403
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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