Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain

Since nicotine and somatostin have regulatory effects on locomotor activity it was of interest to determine whether the receptors for somatostin are modulated by the cholinergic nicotine-like effects. An i.v. dose of 0.3 mg/kg nicotine induced an increase in the concentrations of somatostatin-like i...

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Authors: Barrios Sabador, Vicente, Rodríguez Sánchez, María Nelly, Colás Escudero, María Begoña|||0000-0001-7913-3006, Arilla Ferreiro, Eduardo
Format: article
Publication Date:1990
Country:España
Institution:Universidad de Alcalá (UAH)
Repository:e_Buah Biblioteca Digital Universidad de Alcalá
Language:English
OAI Identifier:oai:ebuah.uah.es:10017/2468
Online Access:http://hdl.handle.net/10017/2468
https://dx.doi.org/10.1016/0014-2999(90)90164-2
Access Level:Open access
Keyword:Rat
Brain
Mecamylamine
Nicotine
Somatostatin receptors
Bioquímica
Ciencia
Biochemistry
Science
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spelling Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brainBarrios Sabador, VicenteRodríguez Sánchez, María NellyColás Escudero, María Begoña|||0000-0001-7913-3006Arilla Ferreiro, EduardoRatBrainMecamylamineNicotineSomatostatin receptorsBioquímicaCienciaBiochemistryScienceSince nicotine and somatostin have regulatory effects on locomotor activity it was of interest to determine whether the receptors for somatostin are modulated by the cholinergic nicotine-like effects. An i.v. dose of 0.3 mg/kg nicotine induced an increase in the concentrations of somatostatin-like immunoreactivity at 4 min in the parietal cortex and at 15 min in the hippocampus. These changes were associated with a significant increase in the total number of specific somatostatin receptors in the parietal cortex at 15 min and in the hippocampus at 30 min following injection. To determine if the above mentioned changes are related to the nicotine activation of central nicotine-like acetylcholine receptors, a cholinergic nicotinic blocking agent, mecamylamine, was administered before the nicotine injection. Pretreatment with mecamylamine (5.0 mg/kg i.v.) prevented the nicotine-induced changes in somatostatin level and binding in both brain areas. Mecamylamine alone had no observable effect on the somatostatinergic system. These results suggest that the somatostatinergic system can be regulated by nicotine-like acetylcholine receptors and may be involved in some of the behavioral central effects of nicotine.Comisión Interministerial de Ciencia y TecnologíaInstituto de Salud Carlos IIIElsevier19901990-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/2468https://dx.doi.org/10.1016/0014-2999(90)90164-2reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengCICYT Not available PB87-0753 ESTUDIO DE LAS BASES MOLECULARES DE INHIBICIÓN DE LA PROLIFERACIÓN CELULAR INDUCIDA POR LA SOMATOSTATINANot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/24682026-06-18T11:13:07Z
dc.title.none.fl_str_mv Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
title Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
spellingShingle Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
Barrios Sabador, Vicente
Rat
Brain
Mecamylamine
Nicotine
Somatostatin receptors
Bioquímica
Ciencia
Biochemistry
Science
title_short Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
title_full Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
title_fullStr Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
title_full_unstemmed Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
title_sort Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
dc.creator.none.fl_str_mv Barrios Sabador, Vicente
Rodríguez Sánchez, María Nelly
Colás Escudero, María Begoña|||0000-0001-7913-3006
Arilla Ferreiro, Eduardo
author Barrios Sabador, Vicente
author_facet Barrios Sabador, Vicente
Rodríguez Sánchez, María Nelly
Colás Escudero, María Begoña|||0000-0001-7913-3006
Arilla Ferreiro, Eduardo
author_role author
author2 Rodríguez Sánchez, María Nelly
Colás Escudero, María Begoña|||0000-0001-7913-3006
Arilla Ferreiro, Eduardo
author2_role author
author
author
dc.subject.none.fl_str_mv Rat
Brain
Mecamylamine
Nicotine
Somatostatin receptors
Bioquímica
Ciencia
Biochemistry
Science
topic Rat
Brain
Mecamylamine
Nicotine
Somatostatin receptors
Bioquímica
Ciencia
Biochemistry
Science
description Since nicotine and somatostin have regulatory effects on locomotor activity it was of interest to determine whether the receptors for somatostin are modulated by the cholinergic nicotine-like effects. An i.v. dose of 0.3 mg/kg nicotine induced an increase in the concentrations of somatostatin-like immunoreactivity at 4 min in the parietal cortex and at 15 min in the hippocampus. These changes were associated with a significant increase in the total number of specific somatostatin receptors in the parietal cortex at 15 min and in the hippocampus at 30 min following injection. To determine if the above mentioned changes are related to the nicotine activation of central nicotine-like acetylcholine receptors, a cholinergic nicotinic blocking agent, mecamylamine, was administered before the nicotine injection. Pretreatment with mecamylamine (5.0 mg/kg i.v.) prevented the nicotine-induced changes in somatostatin level and binding in both brain areas. Mecamylamine alone had no observable effect on the somatostatinergic system. These results suggest that the somatostatinergic system can be regulated by nicotine-like acetylcholine receptors and may be involved in some of the behavioral central effects of nicotine.
publishDate 1990
dc.date.none.fl_str_mv 1990
1990-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/2468
https://dx.doi.org/10.1016/0014-2999(90)90164-2
url http://hdl.handle.net/10017/2468
https://dx.doi.org/10.1016/0014-2999(90)90164-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv CICYT Not available PB87-0753 ESTUDIO DE LAS BASES MOLECULARES DE INHIBICIÓN DE LA PROLIFERACIÓN CELULAR INDUCIDA POR LA SOMATOSTATINA
Not available Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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