Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort

Background: To compare effectiveness and safety of initial antiretroviral therapy (ART) among premenopausal and postmenopausal women living with HIV aged 45-60 years from the cohort of the Spanish HIV/AIDS Research Network (CoRIS) who initiated ART between 2004 and 2015. Methods: Multivariable regre...

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Autores: Alejos, Belén, Suárez García, Inés, Bernardino, José Ignacio, Blanco Ramos, José Ramón, Peñaranda, María, Bautista, Azucena, Gutiérrez Rodero, Félix, Jarrín, Inmaculada, Hernando, Victoria, CoRIS
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/11442
Acceso en línea:http://hdl.handle.net/11268/11442
Access Level:acceso abierto
Palabra clave:Antirretrovirales
Premenopausia
Menopausia
Mujer
Sida
Tratamiento médico
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spelling Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohortAlejos, BelénSuárez García, InésBernardino, José IgnacioBlanco Ramos, José RamónPeñaranda, MaríaBautista, AzucenaGutiérrez Rodero, FélixJarrín, InmaculadaHernando, VictoriaCoRISAntirretroviralesPremenopausiaMenopausiaMujerSidaTratamiento médicoBackground: To compare effectiveness and safety of initial antiretroviral therapy (ART) among premenopausal and postmenopausal women living with HIV aged 45-60 years from the cohort of the Spanish HIV/AIDS Research Network (CoRIS) who initiated ART between 2004 and 2015. Methods: Multivariable regression models were used to compare post- versus premenopausal women regarding viral suppression (≤50 copies/ml), change in CD4+ T-cell count and time to treatment change (TC) at 48 and 96 weeks after ART initiation. Results: Among 230 women, 154 (67%) were premenopausal at ART initiation. The most frequent initial regimen was tenofovir disoproxil fumarate/emtricitabine/efavirenz prescribed in 49 (32%) premenopausal and 22 (29%) postmenopausal women. The proportion of TC was 35.7% and 30.3% at 48 weeks and 51.3% and 47.4% at 96 weeks, for pre- and postmenopausal women, respectively. There were no significant differences in CD4+ T-cell count changes from ART initiation, viral load suppression, time to TC or reason for TC between both groups. The main reason for TC was occurrence of an adverse event, followed by simplification, in both groups. Conclusions: ART effectiveness and safety did not differ significantly between pre- and postmenopausal women.20222022-07-0820202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/11442reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/114422026-06-11T12:41:27Z
dc.title.none.fl_str_mv Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
title Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
spellingShingle Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
Alejos, Belén
Antirretrovirales
Premenopausia
Menopausia
Mujer
Sida
Tratamiento médico
title_short Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
title_full Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
title_fullStr Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
title_full_unstemmed Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
title_sort Effectiveness and safety of antiretroviral treatment in pre- and postmenopausal women living with HIV in a multicentre cohort
dc.creator.none.fl_str_mv Alejos, Belén
Suárez García, Inés
Bernardino, José Ignacio
Blanco Ramos, José Ramón
Peñaranda, María
Bautista, Azucena
Gutiérrez Rodero, Félix
Jarrín, Inmaculada
Hernando, Victoria
CoRIS
author Alejos, Belén
author_facet Alejos, Belén
Suárez García, Inés
Bernardino, José Ignacio
Blanco Ramos, José Ramón
Peñaranda, María
Bautista, Azucena
Gutiérrez Rodero, Félix
Jarrín, Inmaculada
Hernando, Victoria
CoRIS
author_role author
author2 Suárez García, Inés
Bernardino, José Ignacio
Blanco Ramos, José Ramón
Peñaranda, María
Bautista, Azucena
Gutiérrez Rodero, Félix
Jarrín, Inmaculada
Hernando, Victoria
CoRIS
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Antirretrovirales
Premenopausia
Menopausia
Mujer
Sida
Tratamiento médico
topic Antirretrovirales
Premenopausia
Menopausia
Mujer
Sida
Tratamiento médico
description Background: To compare effectiveness and safety of initial antiretroviral therapy (ART) among premenopausal and postmenopausal women living with HIV aged 45-60 years from the cohort of the Spanish HIV/AIDS Research Network (CoRIS) who initiated ART between 2004 and 2015. Methods: Multivariable regression models were used to compare post- versus premenopausal women regarding viral suppression (≤50 copies/ml), change in CD4+ T-cell count and time to treatment change (TC) at 48 and 96 weeks after ART initiation. Results: Among 230 women, 154 (67%) were premenopausal at ART initiation. The most frequent initial regimen was tenofovir disoproxil fumarate/emtricitabine/efavirenz prescribed in 49 (32%) premenopausal and 22 (29%) postmenopausal women. The proportion of TC was 35.7% and 30.3% at 48 weeks and 51.3% and 47.4% at 96 weeks, for pre- and postmenopausal women, respectively. There were no significant differences in CD4+ T-cell count changes from ART initiation, viral load suppression, time to TC or reason for TC between both groups. The main reason for TC was occurrence of an adverse event, followed by simplification, in both groups. Conclusions: ART effectiveness and safety did not differ significantly between pre- and postmenopausal women.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2022
2022-07-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/11442
url http://hdl.handle.net/11268/11442
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
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