Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL pat...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p7303 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/7303 |
| Access Level: | acceso abierto |
| Palabra clave: | Acute promyelocytic leukemia complex karyotype ATRA chemotherapy prognostic relapse |
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Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapyLabrador, JLuno, EVellenga, EBrunet, SGonzalez-Campose, JChillon, MCHolowiecka, AEsteve, JBergua, JGonzalez-Sanmiguel, JDGil, CTormo, MSalamero, OManso, FFernandez, Ide laSerna, JMoreno, MJPerez-Encinas, MKrsnik, IRibera, JMCervera, JCalasanz, MJBoluda, BSobas, MLowenberg, BSanz, MAMontesinos, PPalmer, LFernandez, ICiarlo, SBezares, FRojas, FLongoni, HGelemur, MFazio, PCanepa, CSaba, SBalladares, GNegri, PGiunta, MMilone, JPrates, MVLafalse, DSossa, CJaramillo, FMayer, JProtivankova, MScwarz, JHolowiecka-Goral, AJakubas, BSkret-Norwicz, ABizgalska-Skrzypek, PPluta, ABecht, RKielbinski, MWatek, MPaluszewska, MGadomska, ARzenno, EPiszcz, JEjduk, ADobrzanska, JCalbecka, MKostyra, AMalek, MGrosicki, SKnopinska, Wde Heredia, JMBHernandez, JMArias, JRamos, FRoman, Ade la Serna, JNegri, SRayon, CEsteve, JFernandez-Calvo, FJDiaz-Mediavilla, JGil, CPerez-Encinas, MTormo, MOlave, MAmutio, EPedro, CGorosquieta, AViguria, MZudaire, MMolero, TSayas, MJGuardia, RManso, FRivas, CEsquembre, CGarcia, RAlcala, ALopez, JARubio, VAmigo, MLLinares, MRibera, JMSan Miguel, JDGDeben, GEscoda, Lde la Camara, RMolines, ALoureiro, CAllegue, MJAmador, LMarti, JMMadero, LLassaletta, ACabezudo, MGarcia-Larana, JRojas, ROrtega, FPenarrubia, MJPuente, FLopez-Ibor, BBrunet, SBergua, JMIbanez, JSanchez, PNovo, AFont, LLGuinea, JMMontero, AGonzalez, MSanz, MAMartin, GMartinez, JMontesinos, PVerdeguer, AGarcia, PConde, EGarcia, JCapote, FJKrsnik, IBueno, JBastida, PRubio, AFuster, JLGonzalez, JPerez, IMolina, JMateos, MCArdaiz, MARodriguez-calvillo, MPoderos, CArnan, MDuarte, RHernandez, JADiaz-Morfa, MMartin-Chacon, ECalvo-Villas, JMGarcia-Belmonte, DHernandez-Maraver, DOssenkoppele, GJvan der Lelie, JLowenberg, BSonneveld, PZijlmans, MVellenga, EMaertens, Jde Valk, BWijermans, PWde Groot, MRSchouten, HCBiesma, DHKooy, MVde Lisa, EPETHEMA GrpHOVON GrpPALG GrpGATLA GrpAcute promyelocytic leukemiacomplex karyotypeATRAchemotherapyprognosticrelapseAlthough additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with <2 ACA (p=.09). Among patients with CK+, the 5-year CIR was 27% vs 12% (p=.003), retaining the statistical significance in multivariate analysis. This study shows an increased risk of relapse among APL patients with CK + treated with ATRA plus chemotherapy front-line regimens.TAYLOR & FRANCIS LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/7303LEUKEMIA & LYMPHOMAISSN: 10428194ISSNe: 10292403ISSNl: 10268022reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p73032026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| title |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| spellingShingle |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy Labrador, J Acute promyelocytic leukemia complex karyotype ATRA chemotherapy prognostic relapse |
| title_short |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| title_full |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| title_fullStr |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| title_full_unstemmed |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| title_sort |
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
| dc.creator.none.fl_str_mv |
Labrador, J Luno, E Vellenga, E Brunet, S Gonzalez-Campose, J Chillon, MC Holowiecka, A Esteve, J Bergua, J Gonzalez-Sanmiguel, JD Gil, C Tormo, M Salamero, O Manso, F Fernandez, I de laSerna, J Moreno, MJ Perez-Encinas, M Krsnik, I Ribera, JM Cervera, J Calasanz, MJ Boluda, B Sobas, M Lowenberg, B Sanz, MA Montesinos, P Palmer, L Fernandez, I Ciarlo, S Bezares, F Rojas, F Longoni, H Gelemur, M Fazio, P Canepa, C Saba, S Balladares, G Negri, P Giunta, M Milone, J Prates, MV Lafalse, D Sossa, C Jaramillo, F Mayer, J Protivankova, M Scwarz, J Holowiecka-Goral, A Jakubas, B Skret-Norwicz, A Bizgalska-Skrzypek, P Pluta, A Becht, R Kielbinski, M Watek, M Paluszewska, M Gadomska, A Rzenno, E Piszcz, J Ejduk, A Dobrzanska, J Calbecka, M Kostyra, A Malek, M Grosicki, S Knopinska, W de Heredia, JMB Hernandez, JM Arias, J Ramos, F Roman, A de la Serna, J Negri, S Rayon, C Esteve, J Fernandez-Calvo, FJ Diaz-Mediavilla, J Gil, C Perez-Encinas, M Tormo, M Olave, M Amutio, E Pedro, C Gorosquieta, A Viguria, M Zudaire, M Molero, T Sayas, MJ Guardia, R Manso, F Rivas, C Esquembre, C Garcia, R Alcala, A Lopez, JA Rubio, V Amigo, ML Linares, M Ribera, JM San Miguel, JDG Deben, G Escoda, L de la Camara, R Molines, A Loureiro, C Allegue, MJ Amador, L Marti, JM Madero, L Lassaletta, A Cabezudo, M Garcia-Larana, J Rojas, R Ortega, F Penarrubia, MJ Puente, F Lopez-Ibor, B Brunet, S Bergua, JM Ibanez, J Sanchez, P Novo, A Font, LL Guinea, JM Montero, A Gonzalez, M Sanz, MA Martin, G Martinez, J Montesinos, P Verdeguer, A Garcia, P Conde, E Garcia, J Capote, FJ Krsnik, I Bueno, J Bastida, P Rubio, A Fuster, JL Gonzalez, J Perez, I Molina, J Mateos, MC Ardaiz, MA Rodriguez-calvillo, M Poderos, C Arnan, M Duarte, R Hernandez, JA Diaz-Morfa, M Martin-Chacon, E Calvo-Villas, JM Garcia-Belmonte, D Hernandez-Maraver, D Ossenkoppele, GJ van der Lelie, J Lowenberg, B Sonneveld, P Zijlmans, M Vellenga, E Maertens, J de Valk, B Wijermans, PW de Groot, MR Schouten, HC Biesma, DH Kooy, MV de Lisa, E PETHEMA Grp HOVON Grp PALG Grp GATLA Grp |
| author |
Labrador, J |
| author_facet |
Labrador, J Luno, E Vellenga, E Brunet, S Gonzalez-Campose, J Chillon, MC Holowiecka, A Esteve, J Bergua, J Gonzalez-Sanmiguel, JD Gil, C Tormo, M Salamero, O Manso, F Fernandez, I de laSerna, J Moreno, MJ Perez-Encinas, M Krsnik, I Ribera, JM Cervera, J Calasanz, MJ Boluda, B Sobas, M Lowenberg, B Sanz, MA Montesinos, P Palmer, L Ciarlo, S Bezares, F Rojas, F Longoni, H Gelemur, M Fazio, P Canepa, C Saba, S Balladares, G Negri, P Giunta, M Milone, J Prates, MV Lafalse, D Sossa, C Jaramillo, F Mayer, J Protivankova, M Scwarz, J Holowiecka-Goral, A Jakubas, B Skret-Norwicz, A Bizgalska-Skrzypek, P Pluta, A Becht, R Kielbinski, M Watek, M Paluszewska, M Gadomska, A Rzenno, E Piszcz, J Ejduk, A Dobrzanska, J Calbecka, M Kostyra, A Malek, M Grosicki, S Knopinska, W de Heredia, JMB Hernandez, JM Arias, J Ramos, F Roman, A de la Serna, J Negri, S Rayon, C Fernandez-Calvo, FJ Diaz-Mediavilla, J Olave, M Amutio, E Pedro, C Gorosquieta, A Viguria, M Zudaire, M Molero, T Sayas, MJ Guardia, R Rivas, C Esquembre, C Garcia, R Alcala, A Lopez, JA Rubio, V Amigo, ML Linares, M San Miguel, JDG Deben, G Escoda, L de la Camara, R Molines, A Loureiro, C Allegue, MJ Amador, L Marti, JM Madero, L Lassaletta, A Cabezudo, M Garcia-Larana, J Rojas, R Ortega, F Penarrubia, MJ Puente, F Lopez-Ibor, B Bergua, JM Ibanez, J Sanchez, P Novo, A Font, LL Guinea, JM Montero, A Gonzalez, M Martin, G Martinez, J Verdeguer, A Garcia, P Conde, E Garcia, J Capote, FJ Bueno, J Bastida, P Rubio, A Fuster, JL Gonzalez, J Perez, I Molina, J Mateos, MC Ardaiz, MA Rodriguez-calvillo, M Poderos, C Arnan, M Duarte, R Hernandez, JA Diaz-Morfa, M Martin-Chacon, E Calvo-Villas, JM Garcia-Belmonte, D Hernandez-Maraver, D Ossenkoppele, GJ van der Lelie, J Sonneveld, P Zijlmans, M Maertens, J de Valk, B Wijermans, PW de Groot, MR Schouten, HC Biesma, DH Kooy, MV de Lisa, E PETHEMA Grp HOVON Grp PALG Grp GATLA Grp |
| author_role |
author |
| author2 |
Luno, E Vellenga, E Brunet, S Gonzalez-Campose, J Chillon, MC Holowiecka, A Esteve, J Bergua, J Gonzalez-Sanmiguel, JD Gil, C Tormo, M Salamero, O Manso, F Fernandez, I de laSerna, J Moreno, MJ Perez-Encinas, M Krsnik, I Ribera, JM Cervera, J Calasanz, MJ Boluda, B Sobas, M Lowenberg, B Sanz, MA Montesinos, P Palmer, L Ciarlo, S Bezares, F Rojas, F Longoni, H Gelemur, M Fazio, P Canepa, C Saba, S Balladares, G Negri, P Giunta, M Milone, J Prates, MV Lafalse, D Sossa, C Jaramillo, F Mayer, J Protivankova, M Scwarz, J Holowiecka-Goral, A Jakubas, B Skret-Norwicz, A Bizgalska-Skrzypek, P Pluta, A Becht, R Kielbinski, M Watek, M Paluszewska, M Gadomska, A Rzenno, E Piszcz, J Ejduk, A Dobrzanska, J Calbecka, M Kostyra, A Malek, M Grosicki, S Knopinska, W de Heredia, JMB Hernandez, JM Arias, J Ramos, F Roman, A de la Serna, J Negri, S Rayon, C Fernandez-Calvo, FJ Diaz-Mediavilla, J Olave, M Amutio, E Pedro, C Gorosquieta, A Viguria, M Zudaire, M Molero, T Sayas, MJ Guardia, R Rivas, C Esquembre, C Garcia, R Alcala, A Lopez, JA Rubio, V Amigo, ML Linares, M San Miguel, JDG Deben, G Escoda, L de la Camara, R Molines, A Loureiro, C Allegue, MJ Amador, L Marti, JM Madero, L Lassaletta, A Cabezudo, M Garcia-Larana, J Rojas, R Ortega, F Penarrubia, MJ Puente, F Lopez-Ibor, B Bergua, JM Ibanez, J Sanchez, P Novo, A Font, LL Guinea, JM Montero, A Gonzalez, M Martin, G Martinez, J Verdeguer, A Garcia, P Conde, E Garcia, J Capote, FJ Bueno, J Bastida, P Rubio, A Fuster, JL Gonzalez, J Perez, I Molina, J Mateos, MC Ardaiz, MA Rodriguez-calvillo, M Poderos, C Arnan, M Duarte, R Hernandez, JA Diaz-Morfa, M Martin-Chacon, E Calvo-Villas, JM Garcia-Belmonte, D Hernandez-Maraver, D Ossenkoppele, GJ van der Lelie, J Sonneveld, P Zijlmans, M Maertens, J de Valk, B Wijermans, PW de Groot, MR Schouten, HC Biesma, DH Kooy, MV de Lisa, E PETHEMA Grp HOVON Grp PALG Grp GATLA Grp |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Acute promyelocytic leukemia complex karyotype ATRA chemotherapy prognostic relapse |
| topic |
Acute promyelocytic leukemia complex karyotype ATRA chemotherapy prognostic relapse |
| description |
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with <2 ACA (p=.09). Among patients with CK+, the 5-year CIR was 27% vs 12% (p=.003), retaining the statistical significance in multivariate analysis. This study shows an increased risk of relapse among APL patients with CK + treated with ATRA plus chemotherapy front-line regimens. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/7303 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/7303 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
TAYLOR & FRANCIS LTD |
| publisher.none.fl_str_mv |
TAYLOR & FRANCIS LTD |
| dc.source.none.fl_str_mv |
LEUKEMIA & LYMPHOMA ISSN: 10428194 ISSNe: 10292403 ISSNl: 10268022 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869413896830320640 |
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15.81155 |