Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

25 p.-5 fig.-1 tab.-1 grph. abst.

Detalles Bibliográficos
Autores: Mollinedo, Faustino, Gajate, Consuelo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/200903
Acceso en línea:http://hdl.handle.net/10261/200903
Access Level:acceso abierto
Palabra clave:Apoptosis
Cancer
Cancer cells
Cell death
Cell invasion
Cell signalling
Cell survival
Cholesterol
Lipid rafts
Raft platfoms
Signal transduction
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spelling Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapyRunning title: Lipid rafts and cancerMollinedo, FaustinoGajate, ConsueloApoptosisCancerCancer cellsCell deathCell invasionCell signallingCell survivalCholesterolLipid raftsRaft platfomsSignal transduction25 p.-5 fig.-1 tab.-1 grph. abst.Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal, non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis (CD44) are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptor and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.This work was supported by the Spanish Ministry of Science, Innovation and Universities (SAF2017-89672-R).Peer reviewedAmerican Society for Biochemistry and Molecular BiologyMinisterio de Ciencia, Innovación y Universidades (España)Mollinedo, Faustino [0000-0002-4939-2434]Gajate, Consuelo [0000-0003-0604-6459]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/200903reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#MICIU/ICTI2017-2020/SAF2017-89672-Rhttps://doi.org/10.1194/jlr.TR119000439Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2009032026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
Running title: Lipid rafts and cancer
title Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
spellingShingle Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
Mollinedo, Faustino
Apoptosis
Cancer
Cancer cells
Cell death
Cell invasion
Cell signalling
Cell survival
Cholesterol
Lipid rafts
Raft platfoms
Signal transduction
title_short Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
title_full Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
title_fullStr Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
title_full_unstemmed Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
title_sort Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy
dc.creator.none.fl_str_mv Mollinedo, Faustino
Gajate, Consuelo
author Mollinedo, Faustino
author_facet Mollinedo, Faustino
Gajate, Consuelo
author_role author
author2 Gajate, Consuelo
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Mollinedo, Faustino [0000-0002-4939-2434]
Gajate, Consuelo [0000-0003-0604-6459]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Apoptosis
Cancer
Cancer cells
Cell death
Cell invasion
Cell signalling
Cell survival
Cholesterol
Lipid rafts
Raft platfoms
Signal transduction
topic Apoptosis
Cancer
Cancer cells
Cell death
Cell invasion
Cell signalling
Cell survival
Cholesterol
Lipid rafts
Raft platfoms
Signal transduction
description 25 p.-5 fig.-1 tab.-1 grph. abst.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/200903
url http://hdl.handle.net/10261/200903
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
MICIU/ICTI2017-2020/SAF2017-89672-R
https://doi.org/10.1194/jlr.TR119000439
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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