Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration

Folding of the mammalian cerebral cortex into sulcal fissures and gyral peaks is the result of complex processes that are incompletely understood. Previously we showed that genetic deletion of Flrt1/3 adhesion molecules causes folding of the smooth mouse cortex into sulci resulting from increased la...

Descripción completa

Detalles Bibliográficos
Autores: Chun, Seung Hee, Yoon, Da Eun, Diaz Almeida, Daniel Santiago, Todorov, Mihail Ivilinov, Straub, Tobias, Ruff, Tobias, Shao, Wei, Yang, Jianjun, Seyit Bremer, Gönül, Shen, Yi-Ru, Ertürk, Ali, Toro Ruiz, Daniel del, Shi, Songhai, Klein, Rüdiger
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::ab039f2246d7e895f781a6212a21af11
Acceso en línea:https://hdl.handle.net/2445/228537
Access Level:acceso abierto
Palabra clave:Escorça cerebral
Evolució del cervell
Neurogenètica
Cerebral cortex
Evolution of the brain
Neurogenetics
id ES_95bfd1df7b66905ca47fbcd897bdf756
oai_identifier_str oai:dnet:recercat____::ab039f2246d7e895f781a6212a21af11
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migrationChun, Seung HeeYoon, Da EunDiaz Almeida, Daniel SantiagoTodorov, Mihail IvilinovStraub, TobiasRuff, TobiasShao, WeiYang, JianjunSeyit Bremer, GönülShen, Yi-RuErtürk, AliToro Ruiz, Daniel delShi, SonghaiKlein, RüdigerEscorça cerebralEvolució del cervellNeurogenèticaCerebral cortexEvolution of the brainNeurogeneticsFolding of the mammalian cerebral cortex into sulcal fissures and gyral peaks is the result of complex processes that are incompletely understood. Previously we showed that genetic deletion of Flrt1/3 adhesion molecules causes folding of the smooth mouse cortex into sulci resulting from increased lateral dispersion and faster neuron migration, without progenitor expansion. Here, we show in mice that combining the Flrt1/3 double knockout with an additional genetic deletion that causes progenitor expansion, greatly enhances cortex folding. Expansion of intermediate progenitors by deletion of Cep83 leads to a relative increase in Flrt-mutant neurons resulting in enhanced formation of sulci. Expansion of apical progenitors by deletion of Fgf10 leads to a relative reduction in Flrt-mutant neurons resulting in enhanced formation of gyri. These results together with computational modeling identify key developmental mechanisms, such as adhesive properties, cell densities and migration of cortical neurons, that cooperate to promote cortical gyrification.Nature Publishing Group2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/228537Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41467-025-62858-9Nature Communications, 2025, vol. 16, num.1https://doi.org/10.1038/s41467-025-62858-9cc-by (c) Seung Hee Chun et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::ab039f2246d7e895f781a6212a21af112026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
title Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
spellingShingle Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
Chun, Seung Hee
Escorça cerebral
Evolució del cervell
Neurogenètica
Cerebral cortex
Evolution of the brain
Neurogenetics
title_short Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
title_full Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
title_fullStr Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
title_full_unstemmed Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
title_sort Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
dc.creator.none.fl_str_mv Chun, Seung Hee
Yoon, Da Eun
Diaz Almeida, Daniel Santiago
Todorov, Mihail Ivilinov
Straub, Tobias
Ruff, Tobias
Shao, Wei
Yang, Jianjun
Seyit Bremer, Gönül
Shen, Yi-Ru
Ertürk, Ali
Toro Ruiz, Daniel del
Shi, Songhai
Klein, Rüdiger
author Chun, Seung Hee
author_facet Chun, Seung Hee
Yoon, Da Eun
Diaz Almeida, Daniel Santiago
Todorov, Mihail Ivilinov
Straub, Tobias
Ruff, Tobias
Shao, Wei
Yang, Jianjun
Seyit Bremer, Gönül
Shen, Yi-Ru
Ertürk, Ali
Toro Ruiz, Daniel del
Shi, Songhai
Klein, Rüdiger
author_role author
author2 Yoon, Da Eun
Diaz Almeida, Daniel Santiago
Todorov, Mihail Ivilinov
Straub, Tobias
Ruff, Tobias
Shao, Wei
Yang, Jianjun
Seyit Bremer, Gönül
Shen, Yi-Ru
Ertürk, Ali
Toro Ruiz, Daniel del
Shi, Songhai
Klein, Rüdiger
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Escorça cerebral
Evolució del cervell
Neurogenètica
Cerebral cortex
Evolution of the brain
Neurogenetics
topic Escorça cerebral
Evolució del cervell
Neurogenètica
Cerebral cortex
Evolution of the brain
Neurogenetics
description Folding of the mammalian cerebral cortex into sulcal fissures and gyral peaks is the result of complex processes that are incompletely understood. Previously we showed that genetic deletion of Flrt1/3 adhesion molecules causes folding of the smooth mouse cortex into sulci resulting from increased lateral dispersion and faster neuron migration, without progenitor expansion. Here, we show in mice that combining the Flrt1/3 double knockout with an additional genetic deletion that causes progenitor expansion, greatly enhances cortex folding. Expansion of intermediate progenitors by deletion of Cep83 leads to a relative increase in Flrt-mutant neurons resulting in enhanced formation of sulci. Expansion of apical progenitors by deletion of Fgf10 leads to a relative reduction in Flrt-mutant neurons resulting in enhanced formation of gyri. These results together with computational modeling identify key developmental mechanisms, such as adhesive properties, cell densities and migration of cortical neurons, that cooperate to promote cortical gyrification.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228537
url https://hdl.handle.net/2445/228537
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41467-025-62858-9
Nature Communications, 2025, vol. 16, num.1
https://doi.org/10.1038/s41467-025-62858-9
dc.rights.none.fl_str_mv cc-by (c) Seung Hee Chun et al., 2025
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Seung Hee Chun et al., 2025
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413863485603840
score 15.811543

Similares en LA Referencia