Mpox: A case study for a one health approach to infectious disease prevention

Mpox has been declared a global health emergency twice by the World Health Organization due to its impacts within and beyond Africa. Enzootic in Central and West African wildlife, mpox outbreaks have resulted from zoonotic spillover, with recent events revealing increased human-to-human transmission...

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Detalles Bibliográficos
Autores: Hayman, David T.S., Koopmans, Marion, Cunningham, Andrew A., Bukachi, Salome A., Masirika, Leandre Murhula, Markotter, Wanda, Mettenleiter, Thomas C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/392431
Acceso en línea:http://hdl.handle.net/10261/392431
Access Level:acceso abierto
Palabra clave:Monkeypox virus
Zoonotic spillover
Reservoir hosts
Infectious disease emergence
Drivers
Epidemiology
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spelling Mpox: A case study for a one health approach to infectious disease preventionHayman, David T.S.Koopmans, MarionCunningham, Andrew A.Bukachi, Salome A.Masirika, Leandre MurhulaMarkotter, WandaMettenleiter, Thomas C.Monkeypox virusZoonotic spilloverReservoir hostsInfectious disease emergenceDriversEpidemiologyMpox has been declared a global health emergency twice by the World Health Organization due to its impacts within and beyond Africa. Enzootic in Central and West African wildlife, mpox outbreaks have resulted from zoonotic spillover, with recent events revealing increased human-to-human transmission. Factors like population growth and environmental disruption, alongside reduced smallpox immunity, increase emergence risk. In addition, the emergence in South Kivu of a distinct subclade of mpox virus points at a currently understudied aspect of mpox virus lineages and their dynamics in reservoir hosts. A One Health approach—integrating human, animal, and environmental science—is essential for reducing the risk of mpox emergence. This approach should encompass ecological studies to understand putative reservoir population dynamics and the potential for interventions, reducing activities that increase human-animal contacts, respectful community engagement to reduce spillover risk from cultural practices (such as hunting multiple species of wildlife for consumption), and socially acceptable and equitable access to medical and non-medical countermeasures to prevent or control ongoing human-to-human transmission. Politically supported collaborative efforts across disciplines with involvement of stakeholders are critical to promote and strengthen socially and environmentally sustainable practices to mitigate future outbreaks.MK receives funding for mpox research from EDCTP under grant agreement No. 101103059 (GREATLIFE) and from HERA (DURABLE), MK and LM received funding from EDCTP project JUA KIVU (grant number 101195116). DTSH is funded by the Percival Carmine Chair in Epidemiology and Public Health and WM is supported by the South African Research Chair initiative of the Department of Science and Innovation and National Research Foundation of South Africa (Grant number 98339).Peer reviewedElsevierEuropean CommissionNational Research Foundation (South Africa)Department of Science and Innovation (South Africa)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/392431reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/664771The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.onehlt.2025.101059https://doi.org/10.1016/j.onehlt.2025.101059Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3924312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mpox: A case study for a one health approach to infectious disease prevention
title Mpox: A case study for a one health approach to infectious disease prevention
spellingShingle Mpox: A case study for a one health approach to infectious disease prevention
Hayman, David T.S.
Monkeypox virus
Zoonotic spillover
Reservoir hosts
Infectious disease emergence
Drivers
Epidemiology
title_short Mpox: A case study for a one health approach to infectious disease prevention
title_full Mpox: A case study for a one health approach to infectious disease prevention
title_fullStr Mpox: A case study for a one health approach to infectious disease prevention
title_full_unstemmed Mpox: A case study for a one health approach to infectious disease prevention
title_sort Mpox: A case study for a one health approach to infectious disease prevention
dc.creator.none.fl_str_mv Hayman, David T.S.
Koopmans, Marion
Cunningham, Andrew A.
Bukachi, Salome A.
Masirika, Leandre Murhula
Markotter, Wanda
Mettenleiter, Thomas C.
author Hayman, David T.S.
author_facet Hayman, David T.S.
Koopmans, Marion
Cunningham, Andrew A.
Bukachi, Salome A.
Masirika, Leandre Murhula
Markotter, Wanda
Mettenleiter, Thomas C.
author_role author
author2 Koopmans, Marion
Cunningham, Andrew A.
Bukachi, Salome A.
Masirika, Leandre Murhula
Markotter, Wanda
Mettenleiter, Thomas C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
National Research Foundation (South Africa)
Department of Science and Innovation (South Africa)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Monkeypox virus
Zoonotic spillover
Reservoir hosts
Infectious disease emergence
Drivers
Epidemiology
topic Monkeypox virus
Zoonotic spillover
Reservoir hosts
Infectious disease emergence
Drivers
Epidemiology
description Mpox has been declared a global health emergency twice by the World Health Organization due to its impacts within and beyond Africa. Enzootic in Central and West African wildlife, mpox outbreaks have resulted from zoonotic spillover, with recent events revealing increased human-to-human transmission. Factors like population growth and environmental disruption, alongside reduced smallpox immunity, increase emergence risk. In addition, the emergence in South Kivu of a distinct subclade of mpox virus points at a currently understudied aspect of mpox virus lineages and their dynamics in reservoir hosts. A One Health approach—integrating human, animal, and environmental science—is essential for reducing the risk of mpox emergence. This approach should encompass ecological studies to understand putative reservoir population dynamics and the potential for interventions, reducing activities that increase human-animal contacts, respectful community engagement to reduce spillover risk from cultural practices (such as hunting multiple species of wildlife for consumption), and socially acceptable and equitable access to medical and non-medical countermeasures to prevent or control ongoing human-to-human transmission. Politically supported collaborative efforts across disciplines with involvement of stakeholders are critical to promote and strengthen socially and environmentally sustainable practices to mitigate future outbreaks.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/392431
url http://hdl.handle.net/10261/392431
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/664771
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.onehlt.2025.101059
https://doi.org/10.1016/j.onehlt.2025.101059
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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