Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases

Introduction: Fracture-related infections (FRIs) are a devastating complication. FRIs are challenging and should be addressed with a multidisciplinary approach. An FRI should be addressed surgically by non-viable bone debridement, local antibiotic deposition, minimization of dead space and fracture...

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Autores: JORGE MORA, ALBERTO AGUSTIN, AMHAZ ESCANLAR, SAMER, Fernández Pose, Sabela, García Iglesias, Adrian, Mandía Mancebo, Fermin Julián, FRANCO TREPAT, ELOI, Guillán Fresco, María, Pino Mínguez, Jesús
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/15484
Acceso en línea:https://www.ncbi.nlm.nih.gov/pubmed/31555500
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757014/pdf/jbjiv04p0155.pdf
http://hdl.handle.net/20.500.11940/15484
Access Level:acceso abierto
Palabra clave:CHUS
IDIS
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oai_identifier_str oai:runa.sergas.gal:20.500.11940/15484
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spelling Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 casesJORGE MORA, ALBERTO AGUSTINAMHAZ ESCANLAR, SAMERFernández Pose, SabelaGarcía Iglesias, AdrianMandía Mancebo, Fermin JuliánFRANCO TREPAT, ELOIGuillán Fresco, MaríaPino Mínguez, JesúsCHUSIDISIntroduction: Fracture-related infections (FRIs) are a devastating complication. FRIs are challenging and should be addressed with a multidisciplinary approach. An FRI should be addressed surgically by non-viable bone debridement, local antibiotic deposition, minimization of dead space and fracture stabilization. Antibiotic-laden PMMA-covered nails are a viable option to face these complications. To demonstrate the safety and utility of commercially available antibiotic-laden PMMA-covered nails, we performed a review of the cases operated in our institution and a cost analysis to compare the cost of a commercial nail to other available alternatives. Material and methods: We designed a retrospective study of consecutive cases to demonstrate the safety and efficacy of antibiotic-laden PMMA-covered commercial nails and designed a cost analysis of commercial coated nails compared to other custom-made alternatives. Results: We treated seven tibias and three femurs. Nine patients fully fit the criteria for FRI. There was one case of reintervention because of persistent drainage. All fractures healed, and in the first year post-intervention, there were no signs or symptoms of infection. There were no complications related to the commercially available nail that was used. There is a small increase in the direct quantifiable cost in commercially available nails, but non-quantifiable cost should be assessed individually. Conclusions: Commercially available antibiotic-laden PMMA-covered nails are a safe and useful treatment option for complicated cases of lower limb long bone reconstruction. The low complication rate and the straightforward technique compensate for the direct cost increase in most situations.2019info:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pubmed/31555500https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757014/pdf/jbjiv04p0155.pdfhttp://hdl.handle.net/20.500.11940/15484reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/154842026-06-12T08:40:47Z
dc.title.none.fl_str_mv Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
title Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
spellingShingle Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
JORGE MORA, ALBERTO AGUSTIN
CHUS
IDIS
title_short Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
title_full Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
title_fullStr Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
title_full_unstemmed Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
title_sort Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases
dc.creator.none.fl_str_mv JORGE MORA, ALBERTO AGUSTIN
AMHAZ ESCANLAR, SAMER
Fernández Pose, Sabela
García Iglesias, Adrian
Mandía Mancebo, Fermin Julián
FRANCO TREPAT, ELOI
Guillán Fresco, María
Pino Mínguez, Jesús
author JORGE MORA, ALBERTO AGUSTIN
author_facet JORGE MORA, ALBERTO AGUSTIN
AMHAZ ESCANLAR, SAMER
Fernández Pose, Sabela
García Iglesias, Adrian
Mandía Mancebo, Fermin Julián
FRANCO TREPAT, ELOI
Guillán Fresco, María
Pino Mínguez, Jesús
author_role author
author2 AMHAZ ESCANLAR, SAMER
Fernández Pose, Sabela
García Iglesias, Adrian
Mandía Mancebo, Fermin Julián
FRANCO TREPAT, ELOI
Guillán Fresco, María
Pino Mínguez, Jesús
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHUS
IDIS
topic CHUS
IDIS
description Introduction: Fracture-related infections (FRIs) are a devastating complication. FRIs are challenging and should be addressed with a multidisciplinary approach. An FRI should be addressed surgically by non-viable bone debridement, local antibiotic deposition, minimization of dead space and fracture stabilization. Antibiotic-laden PMMA-covered nails are a viable option to face these complications. To demonstrate the safety and utility of commercially available antibiotic-laden PMMA-covered nails, we performed a review of the cases operated in our institution and a cost analysis to compare the cost of a commercial nail to other available alternatives. Material and methods: We designed a retrospective study of consecutive cases to demonstrate the safety and efficacy of antibiotic-laden PMMA-covered commercial nails and designed a cost analysis of commercial coated nails compared to other custom-made alternatives. Results: We treated seven tibias and three femurs. Nine patients fully fit the criteria for FRI. There was one case of reintervention because of persistent drainage. All fractures healed, and in the first year post-intervention, there were no signs or symptoms of infection. There were no complications related to the commercially available nail that was used. There is a small increase in the direct quantifiable cost in commercially available nails, but non-quantifiable cost should be assessed individually. Conclusions: Commercially available antibiotic-laden PMMA-covered nails are a safe and useful treatment option for complicated cases of lower limb long bone reconstruction. The low complication rate and the straightforward technique compensate for the direct cost increase in most situations.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.ncbi.nlm.nih.gov/pubmed/31555500
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757014/pdf/jbjiv04p0155.pdf
http://hdl.handle.net/20.500.11940/15484
url https://www.ncbi.nlm.nih.gov/pubmed/31555500
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757014/pdf/jbjiv04p0155.pdf
http://hdl.handle.net/20.500.11940/15484
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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