Low-cost optical fiber multimode interference biosensor based on a glucose sensitive Glucose-Oxidase enzyme thin-film
In this research we report a contribution for the development of low-cost fiber optical biosensors fabricated by the Single Mode-Multi Mode-Single Mode configuration applied for the glucose monitoring considering clinical concentrations ranges in aqueous analytes. Designed devices are evaluated usin...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/53361 |
| Acceso en línea: | https://hdl.handle.net/2454/53361 |
| Access Level: | acceso abierto |
| Palabra clave: | SMS Optical fiber sensors Glucose, Glucose oxidase LBL |
| Sumario: | In this research we report a contribution for the development of low-cost fiber optical biosensors fabricated by the Single Mode-Multi Mode-Single Mode configuration applied for the glucose monitoring considering clinical concentrations ranges in aqueous analytes. Designed devices are evaluated using health standard detection ranges, such as healthy, pre-diabetic, and diabetic stages operating at the visible spectral region. The sensing regions has been prepared by the etching technique in order to improve the interaction between the evanescent wave with the surrounding medium followed by functionalization of enzyme oxidase glucose via the electrostatic self-assembly using by Poly(allylamine hydrochloride) as an immobilizer matrix. The increase of bilayers number over the sensor surface permits us to demonstrate the enhancement of sensitivity and limit of detection. Experimental results permitted the glucose characterization in the range from 0.3 to 2.4 mg mL-1 obtaining a response time of 9 s and a sensitivity of 1.8 nm/(mg mL-1) allowing to detect hypoglycemia and diabetes stages according to the World Health Organization standards. |
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