Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis

Ariza Cardenal, Javier; Solà, Elsa; Elia, Chiara; Barreto, Rogelio; Moreira, Rebeca; Morales Ruiz, Manuel; Graupera, Isabel; Rodríguez Gullello, Ezequiel Alejandro; Huelin, Patricia; Solé Padullés, Cristina; Fernández, Javier; Jiménez Povedano, Wladimiro; Arroyo, Vicente; Ginès i Gibert, Pere

Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis

Background Biomarkers are potentially useful in assessment of outcomes in patients with cirrhosis, but information is very limited. Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important. Aim Analysis of potential usefulness of a panel of urinar...

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Autores:	Ariza Cardenal, Javier, Solà, Elsa, Elia, Chiara, Barreto, Rogelio, Moreira, Rebeca, Morales Ruiz, Manuel, Graupera, Isabel, Rodríguez Gullello, Ezequiel Alejandro, Huelin, Patricia, Solé Padullés, Cristina, Fernández, Javier, Jiménez Povedano, Wladimiro, Arroyo, Vicente, Ginès i Gibert, Pere
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2015
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/102723
Acceso en línea:	https://hdl.handle.net/2445/102723
Access Level:	acceso abierto
Palabra clave:	Cirrosi hepàtica Marcadors bioquímics Anàlisi d'orina Ronyó Malalties del fetge Inflamació Hepatic cirrhosis Biochemical markers Urine analysis Kidney Liver diseases Inflammation

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spelling	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosisAriza Cardenal, JavierSolà, ElsaElia, ChiaraBarreto, RogelioMoreira, RebecaMorales Ruiz, ManuelGraupera, IsabelRodríguez Gullello, Ezequiel AlejandroHuelin, PatriciaSolé Padullés, CristinaFernández, JavierJiménez Povedano, WladimiroArroyo, VicenteGinès i Gibert, PereCirrosi hepàticaMarcadors bioquímicsAnàlisi d'orinaRonyóMalalties del fetgeInflamacióHepatic cirrhosisBiochemical markersUrine analysisKidneyLiver diseasesInflammationBackground Biomarkers are potentially useful in assessment of outcomes in patients with cirrhosis, but information is very limited. Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important. Aim Analysis of potential usefulness of a panel of urinary biomarkers in outcome assessment in cirrhosis. Patients and Methods Fifty-five patients with acute decompensation of cirrhosis were studied: 39 had Acute Kidney Injury (AKI) (Prerenal 12, type-1 HRS (hepatorenal syndrome) 15 and Acute Tubular Necrosis (ATN) 12) and 16 acute decompensation without AKI. Thirty-four patients had Acute-on-chronic liver failure (ACLF). A panel of 12 urinary biomarkers was assessed, using a multiplex assay, for their relationship with ATN, ACLF and mortality. Results Biomarker with best accuracy for ATN diagnosis was NGAL (neutrophil-gelatinase associated lipocalin): 36 [26-125], 104 [58-208] and 1807 [494-3,716] μg/g creatinine in Prerenal-AKI, type-1 HRS and ATN, respectively; p<0.0001 (AUROC 0.957). Other attractive biomarkers for ATN diagnosis were IL-18, albumin, trefoil-factor-3 (TFF-3) and glutathione-S-transferase-π (GST-π) Biomarkers with less accuracy for ATN AUCROC<0.8 were β2-microglobulin, calbindin, cystatin-C, clusterin and KIM-1 (kidney injury molecule-1). For ACLF, the biomarker with the best accuracy was NGAL (ACLF vs. No-ACLF: 165 [67-676] and 32 [19-40] μg/g creatinine; respectively; p<0.0001; AUROC 0.878). Interestingly, other biomarkers with high accuracy for ACLF were osteopontin, albumin, and TFF-3. Biomarkers with best accuracy for prognosis were those associated with ACLF. Conclusions A number of biomarkers appear promising for differential diagnosis between ATN and other types of AKI. The most interesting biomarkers for ACLF and prognosis are NGAL, osteopontin, albumin, and TFF-3. These results support the role of major inflammatory reaction in the pathogenesis of ACLF.Public Library of Science (PLoS)2016201620152016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/102723Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0128145PLoS One, 2015, vol. 10, num. 6, p. 1-14http://dx.doi.org/10.1371/journal.pone.0128145cc-by (c) Ariza, X. et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1027232026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
title	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
spellingShingle	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis Ariza Cardenal, Javier Cirrosi hepàtica Marcadors bioquímics Anàlisi d'orina Ronyó Malalties del fetge Inflamació Hepatic cirrhosis Biochemical markers Urine analysis Kidney Liver diseases Inflammation
title_short	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
title_full	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
title_fullStr	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
title_full_unstemmed	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
title_sort	Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
dc.creator.none.fl_str_mv	Ariza Cardenal, Javier Solà, Elsa Elia, Chiara Barreto, Rogelio Moreira, Rebeca Morales Ruiz, Manuel Graupera, Isabel Rodríguez Gullello, Ezequiel Alejandro Huelin, Patricia Solé Padullés, Cristina Fernández, Javier Jiménez Povedano, Wladimiro Arroyo, Vicente Ginès i Gibert, Pere
author	Ariza Cardenal, Javier
author_facet	Ariza Cardenal, Javier Solà, Elsa Elia, Chiara Barreto, Rogelio Moreira, Rebeca Morales Ruiz, Manuel Graupera, Isabel Rodríguez Gullello, Ezequiel Alejandro Huelin, Patricia Solé Padullés, Cristina Fernández, Javier Jiménez Povedano, Wladimiro Arroyo, Vicente Ginès i Gibert, Pere
author_role	author
author2	Solà, Elsa Elia, Chiara Barreto, Rogelio Moreira, Rebeca Morales Ruiz, Manuel Graupera, Isabel Rodríguez Gullello, Ezequiel Alejandro Huelin, Patricia Solé Padullés, Cristina Fernández, Javier Jiménez Povedano, Wladimiro Arroyo, Vicente Ginès i Gibert, Pere
author2_role	author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Cirrosi hepàtica Marcadors bioquímics Anàlisi d'orina Ronyó Malalties del fetge Inflamació Hepatic cirrhosis Biochemical markers Urine analysis Kidney Liver diseases Inflammation
topic	Cirrosi hepàtica Marcadors bioquímics Anàlisi d'orina Ronyó Malalties del fetge Inflamació Hepatic cirrhosis Biochemical markers Urine analysis Kidney Liver diseases Inflammation
description	Background Biomarkers are potentially useful in assessment of outcomes in patients with cirrhosis, but information is very limited. Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important. Aim Analysis of potential usefulness of a panel of urinary biomarkers in outcome assessment in cirrhosis. Patients and Methods Fifty-five patients with acute decompensation of cirrhosis were studied: 39 had Acute Kidney Injury (AKI) (Prerenal 12, type-1 HRS (hepatorenal syndrome) 15 and Acute Tubular Necrosis (ATN) 12) and 16 acute decompensation without AKI. Thirty-four patients had Acute-on-chronic liver failure (ACLF). A panel of 12 urinary biomarkers was assessed, using a multiplex assay, for their relationship with ATN, ACLF and mortality. Results Biomarker with best accuracy for ATN diagnosis was NGAL (neutrophil-gelatinase associated lipocalin): 36 [26-125], 104 [58-208] and 1807 [494-3,716] μg/g creatinine in Prerenal-AKI, type-1 HRS and ATN, respectively; p<0.0001 (AUROC 0.957). Other attractive biomarkers for ATN diagnosis were IL-18, albumin, trefoil-factor-3 (TFF-3) and glutathione-S-transferase-π (GST-π) Biomarkers with less accuracy for ATN AUCROC<0.8 were β2-microglobulin, calbindin, cystatin-C, clusterin and KIM-1 (kidney injury molecule-1). For ACLF, the biomarker with the best accuracy was NGAL (ACLF vs. No-ACLF: 165 [67-676] and 32 [19-40] μg/g creatinine; respectively; p<0.0001; AUROC 0.878). Interestingly, other biomarkers with high accuracy for ACLF were osteopontin, albumin, and TFF-3. Biomarkers with best accuracy for prognosis were those associated with ACLF. Conclusions A number of biomarkers appear promising for differential diagnosis between ATN and other types of AKI. The most interesting biomarkers for ACLF and prognosis are NGAL, osteopontin, albumin, and TFF-3. These results support the role of major inflammatory reaction in the pathogenesis of ACLF.
publishDate	2015
dc.date.none.fl_str_mv	2015 2016 2016 2016
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/102723
url	https://hdl.handle.net/2445/102723
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0128145 PLoS One, 2015, vol. 10, num. 6, p. 1-14 http://dx.doi.org/10.1371/journal.pone.0128145
dc.rights.none.fl_str_mv	cc-by (c) Ariza, X. et al., 2015 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Ariza, X. et al., 2015 http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	14 p. application/pdf
dc.publisher.none.fl_str_mv	Public Library of Science (PLoS)
publisher.none.fl_str_mv	Public Library of Science (PLoS)
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis

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