Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies

Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal tra...

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Autores: Nagel, I. (Inga)|||/items/eba4b332-4f0c-4920-bb51-e50d40931971, Szczepanowski, M. (Monika)|||/items/938cc847-59ea-422c-b83a-69184222c03f, Martin-Subero, J.I. (Jose Ignacio)|||/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824, Harder, L. (Lana)|||/items/30411a62-f33d-4041-95b9-f2c22c3b993f, Akasaka, T. (T.)|||/items/db07a15b-5029-4962-ad04-032fbd13e90d, Ammerpohl, O. (Ole)|||/items/e3b0e6ab-15af-4331-8e58-42138d41780f, Callet-Bauchu, E. (E.)|||/items/4e3aaf96-67c7-4ce7-a746-4a5bde83d3a3, Gascoyne, R.D (R. D.)|||/items/95ccbefd-1945-4ef9-9237-fdcb3272e9b5, Gesk, S. (Stefan)|||/items/1581967f-af92-431a-9f85-452ee6db19d4, Horsman, D. (D.)|||/items/7e942c8c-779d-442d-a8e0-1291a020a033, Klapper, W. (Wolfram)|||/items/389910f1-9839-4776-b1a1-c2c540c27f88, Majid, A. (Aneela)|||/items/e3cd6f27-2678-4ce6-b2e8-ef3115f249ca, Martínez-Climent, J.A. (José Ángel)|||/items/79ffb953-e6d1-4eff-8a96-46162c04d236, Stilgenbauer, S. (Stepahn)|||/items/f8ca16c2-b178-4061-8680-238864c4c160, Tönnies, H. (Holger)|||/items/7491d6a5-a65f-4951-b494-7b0a1227a710, Dyer, M.J.S. (Martin J. S.)|||/items/c8755bfb-10c9-40c5-8947-1816d876b020, Siebert, R. (Reiner)|||/items/bdb7bfa7-0211-4a62-b287-3b78c803227b
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/17888
Acceso en línea:https://hdl.handle.net/10171/17888
Access Level:acceso abierto
Palabra clave:Telomerase genetics
Telomerase metabolism
Translocation genetic
Tumor markers
TERT protein human
Descripción
Sumario:Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal translocations to IGH and non-IG loci in B-cell neoplasms, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. In addition, cases with genomic amplification of TERT locus were identified. Tumors bearing chromosomal aberrations involving TERT showed higher TERT transcriptional expression and increased telomerase activity. These data suggest that deregulation of TERT gene by chromosomal abnormalities leading to increased telomerase activity might contribute to B-cell lymphomagenesis.

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