Adipose cell metabolism modulation by red wine procyanidins
Flavonoids, and more specifically, red wine procyanidins, have many beneficial effects<br/>against pathologies such as cardiovascular heart disease and related illnesses. Although<br/>adipose tissue has a central role in some of these pathologies, including obesity and diabetes,<br/&g...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/8650 |
| Acceso en línea: | http://www.tdx.cat/TDX-0920105-124753 http://hdl.handle.net/10803/8650 |
| Access Level: | acceso abierto |
| Palabra clave: | metabolisme 3T3-L1 procianidines adipòcit 577 |
| Sumario: | Flavonoids, and more specifically, red wine procyanidins, have many beneficial effects<br/>against pathologies such as cardiovascular heart disease and related illnesses. Although<br/>adipose tissue has a central role in some of these pathologies, including obesity and diabetes,<br/>there is a lack of information about the effects of procyanidins on this tissue. This thesis<br/>addresses this question. The effects of a grape seed procyanidin extract (GSPE) on the lipid<br/>and glucose metabolism of adipocytes were evaluated by taking the 3T3-L1 cell line as a<br/>model of study. Results show that the GSPE has insulinomimetic effects, stimulating glucose<br/>uptake, glycogen synthesis and trigliceride synthesis. To achieve this, the GSPE shares some<br/>of the mechanisms and intracellular mediators of the insulin-signalling pathways (such as<br/>GLUT-4 translocation, PI3K and p38 MAPK) but it must also use other, complementary,<br/>mechanisms. These results suggest that procyanidins have beneficial effects on diabetes<br/>and/or insulin resistance. This is partially proven by in vivo studies that show that GSPE has<br/>antihyperglycemic properties on streptozotozin-induced diabetic rats. Also analyzed in this<br/>thesis are the molecular mechanisms used by GSPE to explain the already described lipolytic<br/>effects. Protein kinase A and PPARã are shown to be involved in these effects. Some of<br/>these results opened up another line of study into the effects of GSPE on the differentiation<br/>process of the 3T3-L1. These studies showed that procyanidins alter the differentiation of<br/>preadipocytes when added at the induction of differentiation. Since an increase in the<br/>number of adipocytes has a negative effect on obesity, this is a promising characteristic of<br/>GSPE that should be taken into account when its possible antiobesity properties are studied. |
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