Maternal Dietary Improvement or Leptin Supplementation During Suckling Mitigates the Long-Term Impact of Maternal Obesogenic Conditions on Inflammatory and Oxidative Stress Biomarkers in the Offspring of Diet-Induced Obese Rats
This study investigates the impact of maternal nutrition during lactation on inflammation and oxidative stress in the offspring of diet-induced obese rats, along with the potential benefits of leptin supplementation during suckling. Dams were fed either a standard diet (SD), a western diet (WD) befo...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/21344 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/21344 |
| Access Level: | acceso abierto |
| Palabra clave: | Diet, Western Oxidative Stress Maternal Nutritional Physiological Phenomena Body Weight Animals, Suckling Inflammation Obesity, Maternal Obesity Lactation Pregnancy Male Liver Biomarkers Leptin Female Rats Animals Adipose Tissue, White Dietary Supplements Prenatal Exposure Delayed Effects Animales Fenómenos Fisiologicos Nutricionales Maternos Biomarcadores Femenino Dieta Occidental Masculino Hígado Lactancia Ratas Obesidad Tejido Adiposo Blanco Inflamación Embarazo Estrés Oxidativo Obesidad Materna Animales Lactantes Leptina Suplementos Dietéticos Efectos Tardíos de la Exposición Prenatal Peso Corporal |
| Sumario: | This study investigates the impact of maternal nutrition during lactation on inflammation and oxidative stress in the offspring of diet-induced obese rats, along with the potential benefits of leptin supplementation during suckling. Dams were fed either a standard diet (SD), a western diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to an SD during lactation (Rev-dams). Offspring were supplemented with leptin or vehicle during suckling and then fed an SD or WD until four months. Offspring of the Rev-dams exhibited improved metabolic indicators, including lower body weight, reduced plasma levels of TNF-alpha, a higher adiponectin/leptin (A/L) ratio, enhanced liver antioxidant defenses, and decreased inflammation markers in white adipose tissue (WAT) compared to WD-dams, with sex differences. Leptin supplementation further modulated these markers, reducing oxidative stress in liver and inflammation in WAT and liver (e.g., hepatic Tnfa expression decreased by 45% (males) and 41% (females) in the WD group on an SD), and improving the A/L ratio, with effects varying by maternal conditions and sex. In conclusion, this study underscores the importance of maternal nutrition and leptin intake during suckling in shaping long-term metabolic and inflammatory health in offspring, offering strategies to mitigate the adverse effects of maternal obesity on future generations. |
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