Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice

Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed t...

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Autores: Baraibar-Churio, Arantxa, Bobadilla, Miriam, Machado, Florencio J.D., Sáinz, Neira, Roncal Mancho, Carmen, Abizanda, Gloria, Prósper, Felipe, Orbe, Josune, Pérez Ruiz, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/56179
Acceso en línea:https://hdl.handle.net/2454/56179
Access Level:acceso abierto
Palabra clave:Matrix metalloproteinases
Muscular dystrophy
Skeletal muscle
Cardiac muscle
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spelling Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic miceBaraibar-Churio, ArantxaBobadilla, MiriamMachado, Florencio J.D.Sáinz, NeiraRoncal Mancho, CarmenAbizanda, GloriaPrósper, FelipeOrbe, JosunePérez Ruiz, AnaMatrix metalloproteinasesMuscular dystrophySkeletal muscleCardiac muscleMatrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles.This work was supported by grants from the Spanish Ministry of Health (PI081919) and the Spanish Ministry of Sciences, Innovation and Universities (PID2020-113822RB-C22).MDPICiencias de la SaludOsasun Zientziak2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/56179reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113822RB-C22© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/561792026-06-17T12:41:47Z
dc.title.none.fl_str_mv Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
title Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
spellingShingle Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
Baraibar-Churio, Arantxa
Matrix metalloproteinases
Muscular dystrophy
Skeletal muscle
Cardiac muscle
title_short Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
title_full Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
title_fullStr Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
title_full_unstemmed Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
title_sort Deficiency of MMP-10 aggravates the diseased phenotype of aged dystrophic mice
dc.creator.none.fl_str_mv Baraibar-Churio, Arantxa
Bobadilla, Miriam
Machado, Florencio J.D.
Sáinz, Neira
Roncal Mancho, Carmen
Abizanda, Gloria
Prósper, Felipe
Orbe, Josune
Pérez Ruiz, Ana
author Baraibar-Churio, Arantxa
author_facet Baraibar-Churio, Arantxa
Bobadilla, Miriam
Machado, Florencio J.D.
Sáinz, Neira
Roncal Mancho, Carmen
Abizanda, Gloria
Prósper, Felipe
Orbe, Josune
Pérez Ruiz, Ana
author_role author
author2 Bobadilla, Miriam
Machado, Florencio J.D.
Sáinz, Neira
Roncal Mancho, Carmen
Abizanda, Gloria
Prósper, Felipe
Orbe, Josune
Pérez Ruiz, Ana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Matrix metalloproteinases
Muscular dystrophy
Skeletal muscle
Cardiac muscle
topic Matrix metalloproteinases
Muscular dystrophy
Skeletal muscle
Cardiac muscle
description Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/56179
url https://hdl.handle.net/2454/56179
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113822RB-C22
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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