Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant

Chronobiological aspects controlled by CLOCK genes may influence obesity incidence. Although there are studies that show an association between the expression of these genes and energy intake, waist circumference or abdominal obesity phenotypes, interactions with appetite have been insufficiently in...

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Autores: Espinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dc, San-Cristobal, R. (Rodrigo)|||/items/8ca491c0-d59a-4422-a5d6-1a9aa6ad534a, Colmenarejo, G. (Gonzalo)|||/items/ce1cd35e-bff2-433c-be6b-d4e4f5447daf, Loria-Kohen, V. (Viviana)|||/items/e8bd2699-5f22-41c8-a4b5-b1874d607d16, Molina, S. (Susana)|||/items/7704b14a-e40d-4118-bf5e-74fdd4abfc3e, Reglero, G. (Guillermo)|||/items/7a7ac250-fbc7-464c-bb20-c4d211424d27, Ramirez-de-Molina, A. (Ana)|||/items/2864ccbb-b712-4f73-99a3-dbf2cf91dddb, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/67695
Acceso en línea:https://hdl.handle.net/10171/67695
Access Level:acceso abierto
Palabra clave:Chronobiology
Biorhythm genes
Obesity
Metabolic syndrome
Polymorphism
Interaction
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spelling Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variantEspinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dcSan-Cristobal, R. (Rodrigo)|||/items/8ca491c0-d59a-4422-a5d6-1a9aa6ad534aColmenarejo, G. (Gonzalo)|||/items/ce1cd35e-bff2-433c-be6b-d4e4f5447dafLoria-Kohen, V. (Viviana)|||/items/e8bd2699-5f22-41c8-a4b5-b1874d607d16Molina, S. (Susana)|||/items/7704b14a-e40d-4118-bf5e-74fdd4abfc3eReglero, G. (Guillermo)|||/items/7a7ac250-fbc7-464c-bb20-c4d211424d27Ramirez-de-Molina, A. (Ana)|||/items/2864ccbb-b712-4f73-99a3-dbf2cf91dddbMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131ChronobiologyBiorhythm genesObesityMetabolic syndromePolymorphismInteractionChronobiological aspects controlled by CLOCK genes may influence obesity incidence. Although there are studies that show an association between the expression of these genes and energy intake, waist circumference or abdominal obesity phenotypes, interactions with appetite have been insufficiently investigated in relation to chrononutrition. The objective was to identify interactions between CLOCK genetic variants involved in appetite status. A total of 442 subjects (329 women, 113 men; aged 18 to 65 years) were recruited. Anthropometric, dietary and lifestyle data were collected by trained nutritionists. Participants were classified according to their appetite feelings with a Likert scale. Multiple linear regression models were used to examine associations of the type genotype x appetite status on adiposity-related variables. p values were corrected by the Bonferroni method. A significant influence was found concerning the effects of appetite on waist circumference with respect to rs3749474 CLOCK polymorphism (p < 0.001). An additive model analysis (adjusted by age, gender, exercise and energy intake) showed that risk allele carriers, increased the waist circumference around 14 cm (β = 14.1, CI = 6.3–22.0) by each increment in the level of appetite. The effects of appetite on waist circumference may be partly modulated by the rs3749474 CLOCK polymorphism.MDPI AGDadun. Depósito Académico Digital Universidad de Navarra20232023-10-2320202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/67695reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/676952026-06-21T12:47:57Z
dc.title.none.fl_str_mv Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
title Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
spellingShingle Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
Espinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dc
Chronobiology
Biorhythm genes
Obesity
Metabolic syndrome
Polymorphism
Interaction
title_short Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
title_full Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
title_fullStr Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
title_full_unstemmed Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
title_sort Polymorphic appetite effects on waist circumference depend on rs3749474 CLOCK gene variant
dc.creator.none.fl_str_mv Espinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dc
San-Cristobal, R. (Rodrigo)|||/items/8ca491c0-d59a-4422-a5d6-1a9aa6ad534a
Colmenarejo, G. (Gonzalo)|||/items/ce1cd35e-bff2-433c-be6b-d4e4f5447daf
Loria-Kohen, V. (Viviana)|||/items/e8bd2699-5f22-41c8-a4b5-b1874d607d16
Molina, S. (Susana)|||/items/7704b14a-e40d-4118-bf5e-74fdd4abfc3e
Reglero, G. (Guillermo)|||/items/7a7ac250-fbc7-464c-bb20-c4d211424d27
Ramirez-de-Molina, A. (Ana)|||/items/2864ccbb-b712-4f73-99a3-dbf2cf91dddb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author Espinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dc
author_facet Espinosa-Salinas, I. (Isabel)|||/items/bc198843-5a80-4889-ab94-aced87b626dc
San-Cristobal, R. (Rodrigo)|||/items/8ca491c0-d59a-4422-a5d6-1a9aa6ad534a
Colmenarejo, G. (Gonzalo)|||/items/ce1cd35e-bff2-433c-be6b-d4e4f5447daf
Loria-Kohen, V. (Viviana)|||/items/e8bd2699-5f22-41c8-a4b5-b1874d607d16
Molina, S. (Susana)|||/items/7704b14a-e40d-4118-bf5e-74fdd4abfc3e
Reglero, G. (Guillermo)|||/items/7a7ac250-fbc7-464c-bb20-c4d211424d27
Ramirez-de-Molina, A. (Ana)|||/items/2864ccbb-b712-4f73-99a3-dbf2cf91dddb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author_role author
author2 San-Cristobal, R. (Rodrigo)|||/items/8ca491c0-d59a-4422-a5d6-1a9aa6ad534a
Colmenarejo, G. (Gonzalo)|||/items/ce1cd35e-bff2-433c-be6b-d4e4f5447daf
Loria-Kohen, V. (Viviana)|||/items/e8bd2699-5f22-41c8-a4b5-b1874d607d16
Molina, S. (Susana)|||/items/7704b14a-e40d-4118-bf5e-74fdd4abfc3e
Reglero, G. (Guillermo)|||/items/7a7ac250-fbc7-464c-bb20-c4d211424d27
Ramirez-de-Molina, A. (Ana)|||/items/2864ccbb-b712-4f73-99a3-dbf2cf91dddb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Chronobiology
Biorhythm genes
Obesity
Metabolic syndrome
Polymorphism
Interaction
topic Chronobiology
Biorhythm genes
Obesity
Metabolic syndrome
Polymorphism
Interaction
description Chronobiological aspects controlled by CLOCK genes may influence obesity incidence. Although there are studies that show an association between the expression of these genes and energy intake, waist circumference or abdominal obesity phenotypes, interactions with appetite have been insufficiently investigated in relation to chrononutrition. The objective was to identify interactions between CLOCK genetic variants involved in appetite status. A total of 442 subjects (329 women, 113 men; aged 18 to 65 years) were recruited. Anthropometric, dietary and lifestyle data were collected by trained nutritionists. Participants were classified according to their appetite feelings with a Likert scale. Multiple linear regression models were used to examine associations of the type genotype x appetite status on adiposity-related variables. p values were corrected by the Bonferroni method. A significant influence was found concerning the effects of appetite on waist circumference with respect to rs3749474 CLOCK polymorphism (p < 0.001). An additive model analysis (adjusted by age, gender, exercise and energy intake) showed that risk allele carriers, increased the waist circumference around 14 cm (β = 14.1, CI = 6.3–22.0) by each increment in the level of appetite. The effects of appetite on waist circumference may be partly modulated by the rs3749474 CLOCK polymorphism.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2023
2023-10-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/67695
url https://hdl.handle.net/10171/67695
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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