Gene expression analysis of aberrant signaling pathways in meningiomas

Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the e...

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Autores: Torres-Martín, Miguel, Martínez-Glez, Víctor, Peña-Granero, Carolina, Isla Guerrero, Alberto José, Lassaletta Atienza, Luis María, De Campos, José Maria, Pinto, Giovanny R., Burbano, Rommel Rodríguez Rodríguez, Meléndez, Bárbara, Castresana, Javier Sáez, Rey, Juan Antonio
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/665025
Acceso en línea:http://hdl.handle.net/10486/665025
https://dx.doi.org/10.3892/ol.2013.1363
Access Level:acceso abierto
Palabra clave:Gene expression arrays
Meningioma
Neurofibromin gene
Schwannoma
Signaling pathways
Medicina
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spelling Gene expression analysis of aberrant signaling pathways in meningiomasTorres-Martín, MiguelMartínez-Glez, VíctorPeña-Granero, CarolinaIsla Guerrero, Alberto JoséLassaletta Atienza, Luis MaríaDe Campos, José MariaPinto, Giovanny R.Burbano, Rommel Rodríguez RodríguezMeléndez, BárbaraCastresana, Javier SáezRey, Juan AntonioGene expression arraysMeningiomaNeurofibromin geneSchwannomaSignaling pathwaysMedicinaExamining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene, NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningiomaThis study was partially supported by Fondo de Investigaciones Sanitarias, Ministerio de Ciencia e Innovación, Spain, Grants PI‑08/1849 and PI‑10/1972; and by grant PI‑10‑045 from the Fundación Sociosanitaria de Castilla‑La Mancha, SpainSpandidos PublicationsDepartamento de CirugíaFacultad de Medicina20132013-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/665025https://dx.doi.org/10.3892/ol.2013.1363reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6650252026-06-23T12:46:27Z
dc.title.none.fl_str_mv Gene expression analysis of aberrant signaling pathways in meningiomas
title Gene expression analysis of aberrant signaling pathways in meningiomas
spellingShingle Gene expression analysis of aberrant signaling pathways in meningiomas
Torres-Martín, Miguel
Gene expression arrays
Meningioma
Neurofibromin gene
Schwannoma
Signaling pathways
Medicina
title_short Gene expression analysis of aberrant signaling pathways in meningiomas
title_full Gene expression analysis of aberrant signaling pathways in meningiomas
title_fullStr Gene expression analysis of aberrant signaling pathways in meningiomas
title_full_unstemmed Gene expression analysis of aberrant signaling pathways in meningiomas
title_sort Gene expression analysis of aberrant signaling pathways in meningiomas
dc.creator.none.fl_str_mv Torres-Martín, Miguel
Martínez-Glez, Víctor
Peña-Granero, Carolina
Isla Guerrero, Alberto José
Lassaletta Atienza, Luis María
De Campos, José Maria
Pinto, Giovanny R.
Burbano, Rommel Rodríguez Rodríguez
Meléndez, Bárbara
Castresana, Javier Sáez
Rey, Juan Antonio
author Torres-Martín, Miguel
author_facet Torres-Martín, Miguel
Martínez-Glez, Víctor
Peña-Granero, Carolina
Isla Guerrero, Alberto José
Lassaletta Atienza, Luis María
De Campos, José Maria
Pinto, Giovanny R.
Burbano, Rommel Rodríguez Rodríguez
Meléndez, Bárbara
Castresana, Javier Sáez
Rey, Juan Antonio
author_role author
author2 Martínez-Glez, Víctor
Peña-Granero, Carolina
Isla Guerrero, Alberto José
Lassaletta Atienza, Luis María
De Campos, José Maria
Pinto, Giovanny R.
Burbano, Rommel Rodríguez Rodríguez
Meléndez, Bárbara
Castresana, Javier Sáez
Rey, Juan Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Cirugía
Facultad de Medicina
dc.subject.none.fl_str_mv Gene expression arrays
Meningioma
Neurofibromin gene
Schwannoma
Signaling pathways
Medicina
topic Gene expression arrays
Meningioma
Neurofibromin gene
Schwannoma
Signaling pathways
Medicina
description Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene, NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningioma
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-07-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/665025
https://dx.doi.org/10.3892/ol.2013.1363
url http://hdl.handle.net/10486/665025
https://dx.doi.org/10.3892/ol.2013.1363
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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