Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from ex...

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Detalles Bibliográficos
Autores: Martini, Daniela, Chiavaroli, Laura, González-Sarrías, Antonio, Bresciani, Letizia, Palma-Duran, Susana A., Dall'Asta, Margherita, Deligiannidou, Georgia-Eirini, Massaro, Marika, Scoditti, Egeria, Combet, Emilie, Maksimova, Viktorija, Urpí Sardà, Mireia, Kontogiorgis, Christos A., Andrés Lacueva, Ma. Cristina, Gibney, Eileen R., Del Rio, Daniele, Morand, Christine, Garcia Aloy, Mar, Rodriguez-Mateos, Ana, Mena, Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/156083
Acceso en línea:https://hdl.handle.net/2445/156083
Access Level:acceso abierto
Palabra clave:Vegetarianisme
Compostos bioactius
Polifenols
Malalties cardiovasculars
Vegetarianism
Bioactive compounds
Polyphenols
Cardiovascular diseases
Descripción
Sumario:Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.

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