Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections

Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune resp...

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Detalhes bibliográficos
Autores: Ramos, Irene, Stamatakis Andriani, Konstantinos, L. Oeste, clara, Pérez- Sala, Dolores
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708894
Acesso em linha:http://hdl.handle.net/10486/708894
https://dx.doi.org/10.3390/ijms21134675
Access Level:acceso abierto
Palavra-chave:Vimentin
Cell surface vimentin
SARS-CoV
Vimentin–pathogen interactions
Anti-vimentin autoantibodies
Inflammation
Intermediate filaments
Posttranslational modifications
Tissue damage and repair
Immune response
Biología y Biomedicina / Biología
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spelling Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral InfectionsRamos, IreneStamatakis Andriani, KonstantinosL. Oeste, claraPérez- Sala, DoloresVimentinCell surface vimentinSARS-CoVVimentin–pathogen interactionsAnti-vimentin autoantibodiesInflammationIntermediate filamentsPosttranslational modificationsTissue damage and repairImmune responseBiología y Biomedicina / BiologíaVimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal. Although vimentin is a predominantly cytoplasmic protein, it can also appear at extracellular locations, either in a secreted form or at the surface of numerous cell types, often in relation to cell activation, inflammation, injury or senescence. Cell surface targeting of vimentin appears to associate with the occurrence of certain posttranslational modifications, such as phosphorylation and/or oxidative damage. At the cell surface, vimentin can act as a receptor for bacterial and viral pathogens. Indeed, vimentin has been shown to play important roles in virus attachment and entry of severe acute respiratory syndrome-related coronavirus (SARS-CoV), dengue and encephalitis viruses, among others. Moreover, the presence of vimentin in specific virus-targeted cells and its induction by proinflammatory cytokines and tissue damage contribute to its implication in viral infection. Here, we recapitulate some of the pathophysiological implications of vimentin, including the involvement of cell surface vimentin in interaction with pathogens, with a special focus on its role as a cellular receptor or co-receptor for viruses. In addition, we provide a perspective on approaches to target vimentin, including antibodies or chemical agents that could modulate these interactions to potentially interfere with viral pathogenesis, which could be useful when multi-target antiviral strategies are neededWork in DPS laboratory is supported by Grants from Agencia Estatal de Investigación, MINECO/FEDER, Spain, RTI2018-097624-B-I00, Instituto de Salud Carlos III/FEDER, RETIC Aradyal RD16/0006/0021, and CSIC PTI Global Health (PIE 202020E223/CSIC-COVID-19-100). IR research is partially supported by the NIH/National Institute of Allergy and Infectious Diseases-funded centers PRIME (Program for Research on Immune Modeling and Experimentation, U19AI117873), and DHIPC (Dengue Human Immunology Project Consortium, 1U19AI118610).Departamento de Biología MolecularFacultad de Ciencias20202020-06-30review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708894https://dx.doi.org/10.3390/ijms21134675reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7088942026-06-23T12:46:27Z
dc.title.none.fl_str_mv Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
title Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
spellingShingle Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
Ramos, Irene
Vimentin
Cell surface vimentin
SARS-CoV
Vimentin–pathogen interactions
Anti-vimentin autoantibodies
Inflammation
Intermediate filaments
Posttranslational modifications
Tissue damage and repair
Immune response
Biología y Biomedicina / Biología
title_short Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
title_full Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
title_fullStr Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
title_full_unstemmed Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
title_sort Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
dc.creator.none.fl_str_mv Ramos, Irene
Stamatakis Andriani, Konstantinos
L. Oeste, clara
Pérez- Sala, Dolores
author Ramos, Irene
author_facet Ramos, Irene
Stamatakis Andriani, Konstantinos
L. Oeste, clara
Pérez- Sala, Dolores
author_role author
author2 Stamatakis Andriani, Konstantinos
L. Oeste, clara
Pérez- Sala, Dolores
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Vimentin
Cell surface vimentin
SARS-CoV
Vimentin–pathogen interactions
Anti-vimentin autoantibodies
Inflammation
Intermediate filaments
Posttranslational modifications
Tissue damage and repair
Immune response
Biología y Biomedicina / Biología
topic Vimentin
Cell surface vimentin
SARS-CoV
Vimentin–pathogen interactions
Anti-vimentin autoantibodies
Inflammation
Intermediate filaments
Posttranslational modifications
Tissue damage and repair
Immune response
Biología y Biomedicina / Biología
description Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal. Although vimentin is a predominantly cytoplasmic protein, it can also appear at extracellular locations, either in a secreted form or at the surface of numerous cell types, often in relation to cell activation, inflammation, injury or senescence. Cell surface targeting of vimentin appears to associate with the occurrence of certain posttranslational modifications, such as phosphorylation and/or oxidative damage. At the cell surface, vimentin can act as a receptor for bacterial and viral pathogens. Indeed, vimentin has been shown to play important roles in virus attachment and entry of severe acute respiratory syndrome-related coronavirus (SARS-CoV), dengue and encephalitis viruses, among others. Moreover, the presence of vimentin in specific virus-targeted cells and its induction by proinflammatory cytokines and tissue damage contribute to its implication in viral infection. Here, we recapitulate some of the pathophysiological implications of vimentin, including the involvement of cell surface vimentin in interaction with pathogens, with a special focus on its role as a cellular receptor or co-receptor for viruses. In addition, we provide a perspective on approaches to target vimentin, including antibodies or chemical agents that could modulate these interactions to potentially interfere with viral pathogenesis, which could be useful when multi-target antiviral strategies are needed
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-06-30
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708894
https://dx.doi.org/10.3390/ijms21134675
url http://hdl.handle.net/10486/708894
https://dx.doi.org/10.3390/ijms21134675
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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