A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial

The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benef...

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Autores: Farràs, Marta, Arranz, Sara, Carrión Bolorino, Silvia, Subirana Cachinero, Isaac, Muñoz-Aguayo, Daniel, Blanchart, Gemma, Kool, Marjon, Solà, Rosa, Motilva Casado, Mª José, Escolà Gil, Joan Carles, Rubió Piqué, Laura, Fernández Castillejo, Sara, Pedret, Anna, Estruch Riba, Ramon, Covas Planells, María Isabel, Fitó, Montserrat, Hernáez Camba, Álvaro, Castañer, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/67574
Acceso en línea:https://doi.org/10.3390/nu11081732
http://hdl.handle.net/10459.1/67574
Access Level:acceso abierto
Palabra clave:Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Cholesterol efflux
Transcriptomics
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spelling A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trialFarràs, MartaArranz, SaraCarrión Bolorino, SilviaSubirana Cachinero, IsaacMuñoz-Aguayo, DanielBlanchart, GemmaKool, MarjonSolà, RosaMotilva Casado, Mª JoséEscolà Gil, Joan CarlesRubió Piqué, LauraFernández Castillejo, SaraPedret, AnnaEstruch Riba, RamonCovas Planells, María IsabelFitó, MontserratHernáez Camba, ÁlvaroCastañer, OlgaFunctional virgin olive oilOlive oil phenolic compoundsThyme phenolic compoundsCholesterol effluxTranscriptomicsThe consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (p = 0.041 and p = 0.053, versus baseline and the control intervention, respectively), CAV1 (p = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (p = 0.005, p = 0.005, and p = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.This research was funded by: the Spanish Ministry of Economy and Competitiveness (AGL2009-13517-C03-01, AGL2012-40144-C03-01), the Instituto de Salud Carlos III (CB06/03/0028, CB07/08/0016, CD17/00122, CD17/00233, and JR17/00022), FEDER funds (CB06/03), and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2014-SGR-240, 2017-SGR-522).MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/nu11081732http://hdl.handle.net/10459.1/67574reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01info:eu-repo/grantAgreement/MICINN//AGL2012-40114-C03-01Reproducció del document publicat a: https://doi.org/10.3390/nu11081732Nutrients, 2019, vol. 11, num. 8, p. 1732cc-by (c) Farràs, Marta et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/675742026-06-24T12:42:17Z
dc.title.none.fl_str_mv A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
title A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
spellingShingle A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
Farràs, Marta
Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Cholesterol efflux
Transcriptomics
title_short A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
title_full A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
title_fullStr A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
title_full_unstemmed A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
title_sort A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
dc.creator.none.fl_str_mv Farràs, Marta
Arranz, Sara
Carrión Bolorino, Silvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, Daniel
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva Casado, Mª José
Escolà Gil, Joan Carles
Rubió Piqué, Laura
Fernández Castillejo, Sara
Pedret, Anna
Estruch Riba, Ramon
Covas Planells, María Isabel
Fitó, Montserrat
Hernáez Camba, Álvaro
Castañer, Olga
author Farràs, Marta
author_facet Farràs, Marta
Arranz, Sara
Carrión Bolorino, Silvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, Daniel
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva Casado, Mª José
Escolà Gil, Joan Carles
Rubió Piqué, Laura
Fernández Castillejo, Sara
Pedret, Anna
Estruch Riba, Ramon
Covas Planells, María Isabel
Fitó, Montserrat
Hernáez Camba, Álvaro
Castañer, Olga
author_role author
author2 Arranz, Sara
Carrión Bolorino, Silvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, Daniel
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva Casado, Mª José
Escolà Gil, Joan Carles
Rubió Piqué, Laura
Fernández Castillejo, Sara
Pedret, Anna
Estruch Riba, Ramon
Covas Planells, María Isabel
Fitó, Montserrat
Hernáez Camba, Álvaro
Castañer, Olga
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Cholesterol efflux
Transcriptomics
topic Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Cholesterol efflux
Transcriptomics
description The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (p = 0.041 and p = 0.053, versus baseline and the control intervention, respectively), CAV1 (p = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (p = 0.005, p = 0.005, and p = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/nu11081732
http://hdl.handle.net/10459.1/67574
url https://doi.org/10.3390/nu11081732
http://hdl.handle.net/10459.1/67574
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01
info:eu-repo/grantAgreement/MICINN//AGL2012-40114-C03-01
Reproducció del document publicat a: https://doi.org/10.3390/nu11081732
Nutrients, 2019, vol. 11, num. 8, p. 1732
dc.rights.none.fl_str_mv cc-by (c) Farràs, Marta et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Farràs, Marta et al., 2019
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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