Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.

Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 c...

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Autores: Cecconi, Alberto, Navarrete, Gonzalo, Garcia-Guimaraes, Marcos, Vera, Alberto, Blanco-Dominguez, Rafael, Sanz-Garcia, Ancor, Lozano-Prieto, Marta, Lopez-Melgar, Beatriz, Rivero, Fernando, Martin, Pilar, Sanchez-Madrid, Francisco, de la Fuente, Hortensia, Jimenez-Borreguero, Luis Jesus, Alfonso, Fernando
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/15711
Acceso en línea:http://hdl.handle.net/20.500.12105/15711
Access Level:acceso abierto
Palabra clave:Air Pollutants
Air Pollution
MicroRNAs
Myocardial Infarction
Biomarkers
Humans
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spelling Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.Cecconi, AlbertoNavarrete, GonzaloGarcia-Guimaraes, MarcosVera, AlbertoBlanco-Dominguez, RafaelSanz-Garcia, AncorLozano-Prieto, MartaLopez-Melgar, BeatrizRivero, FernandoMartin, PilarSanchez-Madrid, Franciscode la Fuente, HortensiaJimenez-Borreguero, Luis JesusAlfonso, FernandoAir PollutantsAir PollutionMicroRNAsMyocardial InfarctionBiomarkersHumansAir pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.Nature Publishing GroupMinisterio de Ciencia e Innovación (España)Sociedad Española de CardiologíaMinisterio de Ciencia, Innovación y Universidades (España)Instituto de Salud Carlos III20232023-03-2720222022-03-3020222022-03-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/15711reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/157112026-06-12T12:43:37Z
dc.title.none.fl_str_mv Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
title Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
spellingShingle Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
Cecconi, Alberto
Air Pollutants
Air Pollution
MicroRNAs
Myocardial Infarction
Biomarkers
Humans
title_short Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
title_full Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
title_fullStr Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
title_full_unstemmed Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
title_sort Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.
dc.creator.none.fl_str_mv Cecconi, Alberto
Navarrete, Gonzalo
Garcia-Guimaraes, Marcos
Vera, Alberto
Blanco-Dominguez, Rafael
Sanz-Garcia, Ancor
Lozano-Prieto, Marta
Lopez-Melgar, Beatriz
Rivero, Fernando
Martin, Pilar
Sanchez-Madrid, Francisco
de la Fuente, Hortensia
Jimenez-Borreguero, Luis Jesus
Alfonso, Fernando
author Cecconi, Alberto
author_facet Cecconi, Alberto
Navarrete, Gonzalo
Garcia-Guimaraes, Marcos
Vera, Alberto
Blanco-Dominguez, Rafael
Sanz-Garcia, Ancor
Lozano-Prieto, Marta
Lopez-Melgar, Beatriz
Rivero, Fernando
Martin, Pilar
Sanchez-Madrid, Francisco
de la Fuente, Hortensia
Jimenez-Borreguero, Luis Jesus
Alfonso, Fernando
author_role author
author2 Navarrete, Gonzalo
Garcia-Guimaraes, Marcos
Vera, Alberto
Blanco-Dominguez, Rafael
Sanz-Garcia, Ancor
Lozano-Prieto, Marta
Lopez-Melgar, Beatriz
Rivero, Fernando
Martin, Pilar
Sanchez-Madrid, Francisco
de la Fuente, Hortensia
Jimenez-Borreguero, Luis Jesus
Alfonso, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Sociedad Española de Cardiología
Ministerio de Ciencia, Innovación y Universidades (España)
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Air Pollutants
Air Pollution
MicroRNAs
Myocardial Infarction
Biomarkers
Humans
topic Air Pollutants
Air Pollution
MicroRNAs
Myocardial Infarction
Biomarkers
Humans
description Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-30
2022
2022-03-30
2023
2023-03-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/15711
url http://hdl.handle.net/20.500.12105/15711
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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