Adherence to Childhood Tuberculosis Treatment in Mozambique

BACKGROUND: There is limited literature regarding adherence rates for the treatment of tuberculosis (TB) in children. We aimed to describe TB treatment outcomes and adherence as well as to evaluate associated factors to poor adherence in Mozambican children. METHODS: This is a sub-study of a communi...

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Autores: López Varela, Elisa, Sequera Buzarquis, Victor Guillermo, García-Basteiro, Alberto L., Augusto, Orvalho, Munguambe, Khátia, Sacarlal, Jahit, Alonso, Pedro
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/101648
Acceso en línea:https://hdl.handle.net/2445/101648
Access Level:acceso abierto
Palabra clave:Infància
Tuberculosi
Moçambic
Childhood
Tuberculosis
Mozambique
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spelling Adherence to Childhood Tuberculosis Treatment in MozambiqueLópez Varela, ElisaSequera Buzarquis, Victor GuillermoGarcía-Basteiro, Alberto L.Augusto, OrvalhoMunguambe, KhátiaSacarlal, JahitAlonso, PedroInfànciaTuberculosiMoçambicChildhoodTuberculosisMozambiqueBACKGROUND: There is limited literature regarding adherence rates for the treatment of tuberculosis (TB) in children. We aimed to describe TB treatment outcomes and adherence as well as to evaluate associated factors to poor adherence in Mozambican children. METHODS: This is a sub-study of a community TB incidence study among children <3 years of age. Incomplete adherence included the sum of lost-to-follow-up cases plus those with a delay of > 3 weeks to treatment completion. RESULTS: Fifty TB treatments were assessed. Forty-four (88.0%) patients completed treatment, two (4.0%) died during treatment and four (8.0%) were lost to follow-up. Incomplete adherence was observed in 31.3% (15 of 48) of cases and was associated with malnutrition or history of a migrant mother. CONCLUSION: Although treatment outcome is overall good, there is still a significant proportion of incomplete adherence. Further larger paediatric TB cohorts and qualitative approaches are needed to assess and confirm potential factors for non-adherence.Oxford University Press2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/101648Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1093/tropej/fmw048Journal of Tropical Pediatrics, 2016http://dx.doi.org/10.1093/tropej/fmw048(c) López-Varela et al., 2016info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1016482026-05-27T06:46:51Z
dc.title.none.fl_str_mv Adherence to Childhood Tuberculosis Treatment in Mozambique
title Adherence to Childhood Tuberculosis Treatment in Mozambique
spellingShingle Adherence to Childhood Tuberculosis Treatment in Mozambique
López Varela, Elisa
Infància
Tuberculosi
Moçambic
Childhood
Tuberculosis
Mozambique
title_short Adherence to Childhood Tuberculosis Treatment in Mozambique
title_full Adherence to Childhood Tuberculosis Treatment in Mozambique
title_fullStr Adherence to Childhood Tuberculosis Treatment in Mozambique
title_full_unstemmed Adherence to Childhood Tuberculosis Treatment in Mozambique
title_sort Adherence to Childhood Tuberculosis Treatment in Mozambique
dc.creator.none.fl_str_mv López Varela, Elisa
Sequera Buzarquis, Victor Guillermo
García-Basteiro, Alberto L.
Augusto, Orvalho
Munguambe, Khátia
Sacarlal, Jahit
Alonso, Pedro
author López Varela, Elisa
author_facet López Varela, Elisa
Sequera Buzarquis, Victor Guillermo
García-Basteiro, Alberto L.
Augusto, Orvalho
Munguambe, Khátia
Sacarlal, Jahit
Alonso, Pedro
author_role author
author2 Sequera Buzarquis, Victor Guillermo
García-Basteiro, Alberto L.
Augusto, Orvalho
Munguambe, Khátia
Sacarlal, Jahit
Alonso, Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Infància
Tuberculosi
Moçambic
Childhood
Tuberculosis
Mozambique
topic Infància
Tuberculosi
Moçambic
Childhood
Tuberculosis
Mozambique
description BACKGROUND: There is limited literature regarding adherence rates for the treatment of tuberculosis (TB) in children. We aimed to describe TB treatment outcomes and adherence as well as to evaluate associated factors to poor adherence in Mozambican children. METHODS: This is a sub-study of a community TB incidence study among children <3 years of age. Incomplete adherence included the sum of lost-to-follow-up cases plus those with a delay of > 3 weeks to treatment completion. RESULTS: Fifty TB treatments were assessed. Forty-four (88.0%) patients completed treatment, two (4.0%) died during treatment and four (8.0%) were lost to follow-up. Incomplete adherence was observed in 31.3% (15 of 48) of cases and was associated with malnutrition or history of a migrant mother. CONCLUSION: Although treatment outcome is overall good, there is still a significant proportion of incomplete adherence. Further larger paediatric TB cohorts and qualitative approaches are needed to assess and confirm potential factors for non-adherence.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/101648
url https://hdl.handle.net/2445/101648
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1093/tropej/fmw048
Journal of Tropical Pediatrics, 2016
http://dx.doi.org/10.1093/tropej/fmw048
dc.rights.none.fl_str_mv (c) López-Varela et al., 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) López-Varela et al., 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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