Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study

Background & aims: The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Knowledge is limited on the relationship between circadian genes, chronotype, sleeping patterns, chronutrition an...

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Autores: Molina Montes, Esther, Rodríguez Barranco, Miguel, Ching López, Ana, Artacho, Reyes, Huerta, José María, Amiano, Pilar, Lasheras, Cristina, Moreno Iribas, Conchi, Jimenez Zabala, Ana, Chirlaque, María Dolores, Barricarte, Aurelio, Luján Barroso, Leila, Agudo, Antonio, Jakszyn, Paula, Quirós, José Ramón, Sánchez, María José
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193104
Acesso em linha:https://hdl.handle.net/2445/193104
Access Level:Acceso aberto
Palavra-chave:Cronobiologia
Ritmes circadiaris
Antropometria
Obesitat
Chronobiology
Circadian rhythms
Anthropometry
Obesity
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spelling Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) studyMolina Montes, EstherRodríguez Barranco, MiguelChing López, AnaArtacho, ReyesHuerta, José MaríaAmiano, PilarLasheras, CristinaMoreno Iribas, ConchiJimenez Zabala, AnaChirlaque, María DoloresBarricarte, AurelioLuján Barroso, LeilaAgudo, AntonioJakszyn, PaulaQuirós, José RamónSánchez, María JoséCronobiologiaRitmes circadiarisAntropometriaObesitatChronobiologyCircadian rhythmsAnthropometryObesityBackground & aims: The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Knowledge is limited on the relationship between circadian genes, chronotype, sleeping patterns, chronutrition and obesity. The aim was to explore these associations within the EPIC-Spain cohort study. Methods: There were 3183 subjects with information on twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). Their association was evaluated with: chronotype and sleeping duration/ quality (assessed by questionnaires), chrononutrition (number of meals and timing of intake assessed by a diet history), and also anthropometric measures of obesity at early and late adulthood (in two points in time), such as weight and waist circumference (assessed by physical measurements). Multivariable logistic and linear regression as well as additive genetic models were applied. Odds ratios (ORs), b coefficients, and p-values corrected for multiple comparisons were estimated. Genetic risk scores (GRS) were built to test gene-outcome associations further. Results: At nominal significance level, the variant rs2735611 (PER1 gene) was associated with a 11.6% decrease in long-term weight gain (per-allele b beta - -0.12), whereas three CLOCK gene variants (rs12649507, rs3749474 and rs4864548), were associated with a similar to 20% decrease in waist circumference gain (per-allele beta similar to -0.19). These and other associations with body measures did not hold after multiple testing correction, except waist-to-hip ratio and rs1801260, rs2070062 and rs4580704 (CLOCK gene). Associations with chrononutrition variables, chronotype and sleep duration/quality failed to reach statistical significance. Conversely, a weighted GRS was associated with the evening/late chronotype and with all other outcomes (p < 0.05). The chronotype-GRS was associated with an increased overweight/ obesity risk (vs normal weight) in both early and late adulthood (OR = 2.2; p = 0.004, and OR = 2.1; p = 0.02, respectively). Conclusion: Genetic variants of some circadian clock genes could explain the link between genetic susceptibility to the individual's chronotype and obesity risk.Elsevier BV2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/193104Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.clnu.2022.07.027Clinical Nutrition, 2022, vol. 41, num. 9, p. 1977-1990https://doi.org/10.1016/j.clnu.2022.07.027cc by-nc-nd (c) Molina Montes, Esther et al., 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1931042026-05-27T06:46:51Z
dc.title.none.fl_str_mv Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
title Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
spellingShingle Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
Molina Montes, Esther
Cronobiologia
Ritmes circadiaris
Antropometria
Obesitat
Chronobiology
Circadian rhythms
Anthropometry
Obesity
title_short Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
title_full Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
title_fullStr Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
title_full_unstemmed Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
title_sort Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study
dc.creator.none.fl_str_mv Molina Montes, Esther
Rodríguez Barranco, Miguel
Ching López, Ana
Artacho, Reyes
Huerta, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jimenez Zabala, Ana
Chirlaque, María Dolores
Barricarte, Aurelio
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María José
author Molina Montes, Esther
author_facet Molina Montes, Esther
Rodríguez Barranco, Miguel
Ching López, Ana
Artacho, Reyes
Huerta, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jimenez Zabala, Ana
Chirlaque, María Dolores
Barricarte, Aurelio
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María José
author_role author
author2 Rodríguez Barranco, Miguel
Ching López, Ana
Artacho, Reyes
Huerta, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jimenez Zabala, Ana
Chirlaque, María Dolores
Barricarte, Aurelio
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cronobiologia
Ritmes circadiaris
Antropometria
Obesitat
Chronobiology
Circadian rhythms
Anthropometry
Obesity
topic Cronobiologia
Ritmes circadiaris
Antropometria
Obesitat
Chronobiology
Circadian rhythms
Anthropometry
Obesity
description Background & aims: The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Knowledge is limited on the relationship between circadian genes, chronotype, sleeping patterns, chronutrition and obesity. The aim was to explore these associations within the EPIC-Spain cohort study. Methods: There were 3183 subjects with information on twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). Their association was evaluated with: chronotype and sleeping duration/ quality (assessed by questionnaires), chrononutrition (number of meals and timing of intake assessed by a diet history), and also anthropometric measures of obesity at early and late adulthood (in two points in time), such as weight and waist circumference (assessed by physical measurements). Multivariable logistic and linear regression as well as additive genetic models were applied. Odds ratios (ORs), b coefficients, and p-values corrected for multiple comparisons were estimated. Genetic risk scores (GRS) were built to test gene-outcome associations further. Results: At nominal significance level, the variant rs2735611 (PER1 gene) was associated with a 11.6% decrease in long-term weight gain (per-allele b beta - -0.12), whereas three CLOCK gene variants (rs12649507, rs3749474 and rs4864548), were associated with a similar to 20% decrease in waist circumference gain (per-allele beta similar to -0.19). These and other associations with body measures did not hold after multiple testing correction, except waist-to-hip ratio and rs1801260, rs2070062 and rs4580704 (CLOCK gene). Associations with chrononutrition variables, chronotype and sleep duration/quality failed to reach statistical significance. Conversely, a weighted GRS was associated with the evening/late chronotype and with all other outcomes (p < 0.05). The chronotype-GRS was associated with an increased overweight/ obesity risk (vs normal weight) in both early and late adulthood (OR = 2.2; p = 0.004, and OR = 2.1; p = 0.02, respectively). Conclusion: Genetic variants of some circadian clock genes could explain the link between genetic susceptibility to the individual's chronotype and obesity risk.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193104
url https://hdl.handle.net/2445/193104
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2022.07.027
Clinical Nutrition, 2022, vol. 41, num. 9, p. 1977-1990
https://doi.org/10.1016/j.clnu.2022.07.027
dc.rights.none.fl_str_mv cc by-nc-nd (c) Molina Montes, Esther et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Molina Montes, Esther et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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