Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment

Drug interactions, poor adherence to medication and high-risk sexual behaviour may occur in individuals with HIV using recreational drugs. Thus, we aimed to assess the prevalence of recreational drugs use and to explore its clinical impact in HIV patients on treatment. Observational, cross sectional...

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Autores: Garin, Noe|||0000-0002-1559-9453, Zurita, Beatriz, Velasco, Cesar, Feliu Ribera, Anna|||0000-0003-2074-2231, Gutiérrez Macià, Mª Del Mar, Masip Torne, Montserrat|||0000-0001-9517-2734, Mangues, Ma Antonia|||0000-0002-1438-8515
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186125
Acceso en línea:https://ddd.uab.cat/record/186125
https://dx.doi.org/urn:doi:10.1136/bmjopen-2016-014105
Access Level:acceso abierto
Palabra clave:Recreational drugs
Drug interactions
Medication adherence
Sexual behavior
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spelling Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatmenta cross-sectional studyGarin, Noe|||0000-0002-1559-9453Zurita, BeatrizVelasco, CesarFeliu Ribera, Anna|||0000-0003-2074-2231Gutiérrez Macià, Mª Del MarMasip Torne, Montserrat|||0000-0001-9517-2734Mangues, Ma Antonia|||0000-0002-1438-8515Recreational drugsDrug interactionsMedication adherenceSexual behaviorDrug interactions, poor adherence to medication and high-risk sexual behaviour may occur in individuals with HIV using recreational drugs. Thus, we aimed to assess the prevalence of recreational drugs use and to explore its clinical impact in HIV patients on treatment. Observational, cross sectional, study conducted in a 700 bed university hospital, Barcelona, Spain. A total of 208 adults living with HIV on treatment were included. A questionnaire was administered by clinical pharmacists, including evaluation of sociodemographic variables, past 12-month drug consumption, adherence to antiretrovirals (Simplified Medication Adherence Questionnaire) and high-risk sexual behaviour (condomless sex/multiple partners). Additional data were obtained from clinical records. Recreational drug-antiretroviral interactions were checked in reference databases. Prevalence was calculated for 5% precision and 95% CI. Crude and adjusted binary logistic regressions were performed to identify associations between recreational drug use and adherence problems, and between recreational drug use and high-risk sexual behaviour. From the overall sample, 92 participants (44.2%) consumed recreational drugs over the past 1 year. Of these, 44 (48.8%) had used different types of recreational drugs in this period. We detected 11 recreational substances, including sildenafil and nitrites. The most consumed drugs were: cannabis (68.5%), cocaine (45.5%), nitrites (31.5%), sildenafil (28.3) and ecstasy (19.6%). Relevant interactions occurred in 46 (50%) of the individuals consuming drugs. Recreational drug consumption was found to be related to adherence problems with antiretrovirals (OR: 2.51 (95% CI 1.32 to 4.77) p=0.005) and high-risk sexual behaviour (OR: 2.81 (95% CI 1.47 to 5.39) p=0.002). Recreational drugs are frequently used by HIV patients on treatment. Classical drugs and new substances consumed in sexual context are usual. Recreational drug consumption interferes with several clinical outcomes, including potentially relevant interactions between drugs and antiretrovirals, adherence problems and high-risk sexual behaviour. Thus, there is the urgent need of implementing patient-centred care involving recreational drug consumption.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186125https://dx.doi.org/urn:doi:10.1136/bmjopen-2016-014105reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1861252026-06-06T12:50:31Z
dc.title.none.fl_str_mv Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
a cross-sectional study
title Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
spellingShingle Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
Garin, Noe|||0000-0002-1559-9453
Recreational drugs
Drug interactions
Medication adherence
Sexual behavior
title_short Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
title_full Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
title_fullStr Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
title_full_unstemmed Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
title_sort Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment
dc.creator.none.fl_str_mv Garin, Noe|||0000-0002-1559-9453
Zurita, Beatriz
Velasco, Cesar
Feliu Ribera, Anna|||0000-0003-2074-2231
Gutiérrez Macià, Mª Del Mar
Masip Torne, Montserrat|||0000-0001-9517-2734
Mangues, Ma Antonia|||0000-0002-1438-8515
author Garin, Noe|||0000-0002-1559-9453
author_facet Garin, Noe|||0000-0002-1559-9453
Zurita, Beatriz
Velasco, Cesar
Feliu Ribera, Anna|||0000-0003-2074-2231
Gutiérrez Macià, Mª Del Mar
Masip Torne, Montserrat|||0000-0001-9517-2734
Mangues, Ma Antonia|||0000-0002-1438-8515
author_role author
author2 Zurita, Beatriz
Velasco, Cesar
Feliu Ribera, Anna|||0000-0003-2074-2231
Gutiérrez Macià, Mª Del Mar
Masip Torne, Montserrat|||0000-0001-9517-2734
Mangues, Ma Antonia|||0000-0002-1438-8515
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Recreational drugs
Drug interactions
Medication adherence
Sexual behavior
topic Recreational drugs
Drug interactions
Medication adherence
Sexual behavior
description Drug interactions, poor adherence to medication and high-risk sexual behaviour may occur in individuals with HIV using recreational drugs. Thus, we aimed to assess the prevalence of recreational drugs use and to explore its clinical impact in HIV patients on treatment. Observational, cross sectional, study conducted in a 700 bed university hospital, Barcelona, Spain. A total of 208 adults living with HIV on treatment were included. A questionnaire was administered by clinical pharmacists, including evaluation of sociodemographic variables, past 12-month drug consumption, adherence to antiretrovirals (Simplified Medication Adherence Questionnaire) and high-risk sexual behaviour (condomless sex/multiple partners). Additional data were obtained from clinical records. Recreational drug-antiretroviral interactions were checked in reference databases. Prevalence was calculated for 5% precision and 95% CI. Crude and adjusted binary logistic regressions were performed to identify associations between recreational drug use and adherence problems, and between recreational drug use and high-risk sexual behaviour. From the overall sample, 92 participants (44.2%) consumed recreational drugs over the past 1 year. Of these, 44 (48.8%) had used different types of recreational drugs in this period. We detected 11 recreational substances, including sildenafil and nitrites. The most consumed drugs were: cannabis (68.5%), cocaine (45.5%), nitrites (31.5%), sildenafil (28.3) and ecstasy (19.6%). Relevant interactions occurred in 46 (50%) of the individuals consuming drugs. Recreational drug consumption was found to be related to adherence problems with antiretrovirals (OR: 2.51 (95% CI 1.32 to 4.77) p=0.005) and high-risk sexual behaviour (OR: 2.81 (95% CI 1.47 to 5.39) p=0.002). Recreational drugs are frequently used by HIV patients on treatment. Classical drugs and new substances consumed in sexual context are usual. Recreational drug consumption interferes with several clinical outcomes, including potentially relevant interactions between drugs and antiretrovirals, adherence problems and high-risk sexual behaviour. Thus, there is the urgent need of implementing patient-centred care involving recreational drug consumption.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186125
https://dx.doi.org/urn:doi:10.1136/bmjopen-2016-014105
url https://ddd.uab.cat/record/186125
https://dx.doi.org/urn:doi:10.1136/bmjopen-2016-014105
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
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collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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