Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma

The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. We assessed transcriptome data,...

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Detalles Bibliográficos
Autores: Montal, Robert, Andreu-Oller, Carmen|||0000-0001-7405-9134, Bassaganyas, Laia|||0000-0002-4575-0214, Esteban-Fabró, Roger, Moran, S.|||0000-0003-4192-8983, Montironi, Carla|||0000-0002-1453-2193, Moeini, Agrin, Pinyol, Roser|||0000-0002-0288-6314, Peix, Judit, Cabellos, Laia, Villanueva, Augusto|||0000-0003-3585-3727, Sia, Daniela|||0000-0002-9000-611X, Mazzaferro, Vincenzo|||0000-0002-4013-8085, Esteller, M.|||0000-0003-4490-6093, Llovet, Josep M.|||0000-0003-0547-2667
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236901
Acceso en línea:https://ddd.uab.cat/record/236901
https://dx.doi.org/urn:doi:10.1038/s41416-019-0513-7
Access Level:acceso abierto
Palabra clave:Cancer genomics
Hepatocellular carcinoma
Descripción
Sumario:The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. We assessed transcriptome data, whole-exome sequencing data and DNA methylome profiling of 520 HCC patients from two independent cohorts to identify distinct molecular traits of patients with AFP-high tumours (serum concentration.

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