Linkage of DNA methylation quantitative trait loci to human cancer risk
Epigenetic regulation and, in particular, DNA methyl- ation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts....
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/69344 |
| Acceso en línea: | https://hdl.handle.net/2445/69344 |
| Access Level: | acceso abierto |
| Palabra clave: | ADN Metilació Càncer Epigènesi Marcadors genètics DNA Methylation Cancer Epigenesis Genetic markers |
| id |
ES_940463f065c8cb8ef6a7a07cd3bbf4f3 |
|---|---|
| oai_identifier_str |
oai:diposit.ub.edu:2445/69344 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Linkage of DNA methylation quantitative trait loci to human cancer riskHeyn, HolgerSayols, SergiMoutinho, CátiaVidal, EnriqueSanchez-Mut, Jose VicenteStefansson, Olafur A.Nadal, ErnestMoran, SebastianEyfjord, Jorunn E.González Suárez, EvaPujana Genestar, M. ÁngelEsteller, Manel, 1968-ADNMetilacióCàncerEpigènesiMarcadors genèticsDNAMethylationCancerEpigenesisGenetic markersEpigenetic regulation and, in particular, DNA methyl- ation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts. We propose that interrogating the interplay between polymorphic alleles and DNA methylation is a power- ful method for improving our interpretation of risk alleles identified in genome-wide association studies that otherwise lack mechanistic explanation. We integrated patient cancer risk genotype data and genome-scale DNA methylation profiles of 3,649 pri- mary human tumors, representing 13 solid cancer types. We provide a comprehensive meQTL catalog containing DNA methylation associations for 21% of interrogated cancer risk polymorphisms. Differen- tially methylated loci harbor previously reported and as-yet-unidentified cancer genes. We suggest that such regulation at the DNA level can provide a considerable amount of new information about the biology of cancer-risk alleles.Elsevier Inc.2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/69344Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.celrep.2014.03.016Cell Reports, 2014, vol. 7, pp. 331–338http://dx.doi.org/10.1016/j.celrep.2014.03.016info:eu-repo/grantAgreement/EC/FP7/268626info:eu-repo/grantAgreement/EC/FP7/282510cc by (c) Heyn et al., 2014http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/693442026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| title |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| spellingShingle |
Linkage of DNA methylation quantitative trait loci to human cancer risk Heyn, Holger ADN Metilació Càncer Epigènesi Marcadors genètics DNA Methylation Cancer Epigenesis Genetic markers |
| title_short |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| title_full |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| title_fullStr |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| title_full_unstemmed |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| title_sort |
Linkage of DNA methylation quantitative trait loci to human cancer risk |
| dc.creator.none.fl_str_mv |
Heyn, Holger Sayols, Sergi Moutinho, Cátia Vidal, Enrique Sanchez-Mut, Jose Vicente Stefansson, Olafur A. Nadal, Ernest Moran, Sebastian Eyfjord, Jorunn E. González Suárez, Eva Pujana Genestar, M. Ángel Esteller, Manel, 1968- |
| author |
Heyn, Holger |
| author_facet |
Heyn, Holger Sayols, Sergi Moutinho, Cátia Vidal, Enrique Sanchez-Mut, Jose Vicente Stefansson, Olafur A. Nadal, Ernest Moran, Sebastian Eyfjord, Jorunn E. González Suárez, Eva Pujana Genestar, M. Ángel Esteller, Manel, 1968- |
| author_role |
author |
| author2 |
Sayols, Sergi Moutinho, Cátia Vidal, Enrique Sanchez-Mut, Jose Vicente Stefansson, Olafur A. Nadal, Ernest Moran, Sebastian Eyfjord, Jorunn E. González Suárez, Eva Pujana Genestar, M. Ángel Esteller, Manel, 1968- |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ADN Metilació Càncer Epigènesi Marcadors genètics DNA Methylation Cancer Epigenesis Genetic markers |
| topic |
ADN Metilació Càncer Epigènesi Marcadors genètics DNA Methylation Cancer Epigenesis Genetic markers |
| description |
Epigenetic regulation and, in particular, DNA methyl- ation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts. We propose that interrogating the interplay between polymorphic alleles and DNA methylation is a power- ful method for improving our interpretation of risk alleles identified in genome-wide association studies that otherwise lack mechanistic explanation. We integrated patient cancer risk genotype data and genome-scale DNA methylation profiles of 3,649 pri- mary human tumors, representing 13 solid cancer types. We provide a comprehensive meQTL catalog containing DNA methylation associations for 21% of interrogated cancer risk polymorphisms. Differen- tially methylated loci harbor previously reported and as-yet-unidentified cancer genes. We suggest that such regulation at the DNA level can provide a considerable amount of new information about the biology of cancer-risk alleles. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/69344 |
| url |
https://hdl.handle.net/2445/69344 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1016/j.celrep.2014.03.016 Cell Reports, 2014, vol. 7, pp. 331–338 http://dx.doi.org/10.1016/j.celrep.2014.03.016 info:eu-repo/grantAgreement/EC/FP7/268626 info:eu-repo/grantAgreement/EC/FP7/282510 |
| dc.rights.none.fl_str_mv |
cc by (c) Heyn et al., 2014 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) Heyn et al., 2014 http://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Inc. |
| publisher.none.fl_str_mv |
Elsevier Inc. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
| instname_str |
Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
| collection |
Dipòsit Digital de la UB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869413644498894848 |
| score |
15,300719 |