MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor

MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In a...

Full description

Bibliographic Details
Authors: Kuypers, Kim P. C.|||0000-0001-7634-3809, Torre, Rafael de la|||0000-0002-6765-1866, Farré Albaladejo, Magí|||0000-0001-8338-7543, Pizarro, N., Xicota, Laura|||0000-0003-2832-9214, Ramaekers, Johannes G.|||0000-0003-4553-376X
Format: article
Publication Date:2017
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:187834
Online Access:https://ddd.uab.cat/record/187834
https://dx.doi.org/urn:doi:10.1007/s00213-017-4699-1
Access Level:Open access
Keyword:MDMA
5-HT receptor
Ketanserin
Sound processing
Cognitive bias
Oxytocin
Arousal
id ES_93ffa15bc4fa40a013d419622828d33a
oai_identifier_str oai:ddd.uab.cat:187834
network_acronym_str ES
network_name_str España
repository_id_str
spelling MDMA-induced indifference to negative sounds is mediated by the 5-HT receptorKuypers, Kim P. C.|||0000-0001-7634-3809Torre, Rafael de la|||0000-0002-6765-1866Farré Albaladejo, Magí|||0000-0001-8338-7543Pizarro, N.Xicota, Laura|||0000-0003-2832-9214Ramaekers, Johannes G.|||0000-0003-4553-376XMDMA5-HT receptorKetanserinSound processingCognitive biasOxytocinArousalMDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor. The present study aimed at investigating the effect of MDMA on processing of sounds (Processing of Affective Sounds Task (PAST)) and cognitive biases (Approach-Avoidance Task (AAT)) towards emotional and social stimuli and the role of 5-HT receptor in these effects. Twenty healthy recreational users entered a 2 × 2, placebo-controlled, within-subject study with ketanserin (40 mg) as pre-treatment and MDMA (75 mg) as treatment. Behavioural (PAST, AAT) measures were conducted 90 min after treatment with MDMA, respectively, 120 min after ketanserin. Self-report mood measures and oxytocin concentrations were taken at baseline and before and after behavioural tests. Findings showed that MDMA reduced arousal elicited by negative sounds. This effect was counteracted by ketanserin pre-treatment, indicating involvement of the 5-HT receptor in this process. MDMA did not seem to induce a bias towards emotional and social stimuli. It increased positive and negative mood ratings and elevated oxytocin plasma concentrations. The reduction in arousal levels when listening to negative sounds was not related to the elevated subjective arousal. It is suggested that this decrease in arousal to negative stimuli reflects potentially a lowering of defences, a process that might play a role in the therapeutic process. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/187834https://dx.doi.org/urn:doi:10.1007/s00213-017-4699-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-680open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1878342026-06-06T12:50:31Z
dc.title.none.fl_str_mv MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
title MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
spellingShingle MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
Kuypers, Kim P. C.|||0000-0001-7634-3809
MDMA
5-HT receptor
Ketanserin
Sound processing
Cognitive bias
Oxytocin
Arousal
title_short MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
title_full MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
title_fullStr MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
title_full_unstemmed MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
title_sort MDMA-induced indifference to negative sounds is mediated by the 5-HT receptor
dc.creator.none.fl_str_mv Kuypers, Kim P. C.|||0000-0001-7634-3809
Torre, Rafael de la|||0000-0002-6765-1866
Farré Albaladejo, Magí|||0000-0001-8338-7543
Pizarro, N.
Xicota, Laura|||0000-0003-2832-9214
Ramaekers, Johannes G.|||0000-0003-4553-376X
author Kuypers, Kim P. C.|||0000-0001-7634-3809
author_facet Kuypers, Kim P. C.|||0000-0001-7634-3809
Torre, Rafael de la|||0000-0002-6765-1866
Farré Albaladejo, Magí|||0000-0001-8338-7543
Pizarro, N.
Xicota, Laura|||0000-0003-2832-9214
Ramaekers, Johannes G.|||0000-0003-4553-376X
author_role author
author2 Torre, Rafael de la|||0000-0002-6765-1866
Farré Albaladejo, Magí|||0000-0001-8338-7543
Pizarro, N.
Xicota, Laura|||0000-0003-2832-9214
Ramaekers, Johannes G.|||0000-0003-4553-376X
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MDMA
5-HT receptor
Ketanserin
Sound processing
Cognitive bias
Oxytocin
Arousal
topic MDMA
5-HT receptor
Ketanserin
Sound processing
Cognitive bias
Oxytocin
Arousal
description MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor. The present study aimed at investigating the effect of MDMA on processing of sounds (Processing of Affective Sounds Task (PAST)) and cognitive biases (Approach-Avoidance Task (AAT)) towards emotional and social stimuli and the role of 5-HT receptor in these effects. Twenty healthy recreational users entered a 2 × 2, placebo-controlled, within-subject study with ketanserin (40 mg) as pre-treatment and MDMA (75 mg) as treatment. Behavioural (PAST, AAT) measures were conducted 90 min after treatment with MDMA, respectively, 120 min after ketanserin. Self-report mood measures and oxytocin concentrations were taken at baseline and before and after behavioural tests. Findings showed that MDMA reduced arousal elicited by negative sounds. This effect was counteracted by ketanserin pre-treatment, indicating involvement of the 5-HT receptor in this process. MDMA did not seem to induce a bias towards emotional and social stimuli. It increased positive and negative mood ratings and elevated oxytocin plasma concentrations. The reduction in arousal levels when listening to negative sounds was not related to the elevated subjective arousal. It is suggested that this decrease in arousal to negative stimuli reflects potentially a lowering of defences, a process that might play a role in the therapeutic process.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/187834
https://dx.doi.org/urn:doi:10.1007/s00213-017-4699-1
url https://ddd.uab.cat/record/187834
https://dx.doi.org/urn:doi:10.1007/s00213-017-4699-1
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-680
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413643382161408
score 15.301603

Similar Items