Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles

This article belongs to the Special Issue Single-Chain Polymer Nanotechnology.

Detalhes bibliográficos
Autores: Blázquez-Martín, Agustín, Verde-Sesto, Ester, Moreno Segurado, Ángel J., Arbe, Arantxa, Colmenero de León, Juan, Pomposo, José A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/244250
Acesso em linha:http://hdl.handle.net/10261/244250
Access Level:acceso abierto
Palavra-chave:Folding
Single-chain nanoparticles
Interactions
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spelling Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticlesBlázquez-Martín, AgustínVerde-Sesto, EsterMoreno Segurado, Ángel J.Arbe, ArantxaColmenero de León, JuanPomposo, José A.FoldingSingle-chain nanoparticlesInteractionsThis article belongs to the Special Issue Single-Chain Polymer Nanotechnology.The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.This research was funded by Gipuzkoako Foru Aldundia -Programa Red Gipuzkoana de Ciencia, Tecnología e Innovación 2019-, grant number 2019-CIEN-000050-01; Basque Government, grant number IT-1175-19; and MCIU/AEI/FEDER, UE, grant number PGC2018-094548-B-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteDiputación Foral de GipuzkoaEusko JaurlaritzaMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/244250reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094548-B-I00PGC2018-094548-B-I00/AEI/10.13039/501100011033Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2442502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
title Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
spellingShingle Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
Blázquez-Martín, Agustín
Folding
Single-chain nanoparticles
Interactions
title_short Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
title_full Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
title_fullStr Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
title_full_unstemmed Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
title_sort Advances in the multi-orthogonal folding of single polymer chains into single-chain nanoparticles
dc.creator.none.fl_str_mv Blázquez-Martín, Agustín
Verde-Sesto, Ester
Moreno Segurado, Ángel J.
Arbe, Arantxa
Colmenero de León, Juan
Pomposo, José A.
author Blázquez-Martín, Agustín
author_facet Blázquez-Martín, Agustín
Verde-Sesto, Ester
Moreno Segurado, Ángel J.
Arbe, Arantxa
Colmenero de León, Juan
Pomposo, José A.
author_role author
author2 Verde-Sesto, Ester
Moreno Segurado, Ángel J.
Arbe, Arantxa
Colmenero de León, Juan
Pomposo, José A.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Diputación Foral de Gipuzkoa
Eusko Jaurlaritza
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Folding
Single-chain nanoparticles
Interactions
topic Folding
Single-chain nanoparticles
Interactions
description This article belongs to the Special Issue Single-Chain Polymer Nanotechnology.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/244250
url http://hdl.handle.net/10261/244250
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094548-B-I00
PGC2018-094548-B-I00/AEI/10.13039/501100011033
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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