Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials

Detalhes bibliográficos
Autores: Choubane, Houcine, Garrido-Castro, Alberto F., Alvarado, Cuauhtemoc, Martín-Somer, Ana, Guerrero-Corella, Andrea, Daaou, Mortada, Díaz-Tendero Victoria, Sergio, Carmen Maestro, M., Fraile Carrasco, Alberto, Alemán Lara, José Julián
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/687103
Acesso em linha:http://hdl.handle.net/10486/687103
https://dx.doi.org/10.1039/c8cc01479e
Access Level:acceso abierto
Palavra-chave:Enantioselectivity
Aldehydes
Direct aldo
Química
Descrição
Resumo:The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials

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