Body composition and resting energy expenditure in a group of children with achondroplasia
Background: Persons with achondroplasia develop early obesity, which is a comorbidity associated with other complications. Currently, there are no validated specific predictive equations to estimate resting energy expenditure in achondroplasia. Methods: We analyzed the influence of body composition...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/47339 |
| Acceso en línea: | https://hdl.handle.net/2454/47339 |
| Access Level: | acceso abierto |
| Palabra clave: | Achondroplasia Resting energy expenditure Obesity Indirect calorimetry Body composition |
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Body composition and resting energy expenditure in a group of children with achondroplasiaGarde-Etayo, LauraTrandafir, Paula CameliaSaint-Laurent, CélineUgarte Martínez, María DoloresInsausti Serrano, Ana MaríaAchondroplasiaResting energy expenditureObesityIndirect calorimetryBody compositionBackground: Persons with achondroplasia develop early obesity, which is a comorbidity associated with other complications. Currently, there are no validated specific predictive equations to estimate resting energy expenditure in achondroplasia. Methods: We analyzed the influence of body composition on this parameter and determined whether predictive models used for children with standard height are adjusted to achondroplasia. In this cross-sectional study, we measured anthropometric parameters in children with achondroplasia. Fat mass was obtained using the Slaughter skinfold-thickness equation and resting energy expenditure was determined with a Fitmate-Cosmed calorimeter and with predictive models validated for children with average height (Schofield, Institute of Medicine, and Tverskaya). Results: All of the equations yielded a lower mean value than resting energy expenditure with indirect calorimetry (1256±200 kcal/day [mean±SD]) but the closest was the Tverskaya equation (1017 ± 64 kcal/day), although the difference remained statistically significant. We conclude that weight and height have the greatest influence on resting energy expenditure. Conclusion: We recommend studying the relationship between body composition and energy expenditure in achondroplasia in more depth. In the absence of valid predictive models suitable for clinical use to estimate body composition and resting energy expenditure in achondroplasia, it is recommended to use the gold standard methods by taking into account certain anthropometric parameters.ElsevierCiencias de la SaludEstadística, Informática y MatemáticasOsasun ZientziakEstatistika, Informatika eta MatematikaInstitute for Advanced Materials and Mathematics - INAMAT22024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/47339reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/473392026-06-17T12:41:47Z |
| dc.title.none.fl_str_mv |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| title |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| spellingShingle |
Body composition and resting energy expenditure in a group of children with achondroplasia Garde-Etayo, Laura Achondroplasia Resting energy expenditure Obesity Indirect calorimetry Body composition |
| title_short |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| title_full |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| title_fullStr |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| title_full_unstemmed |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| title_sort |
Body composition and resting energy expenditure in a group of children with achondroplasia |
| dc.creator.none.fl_str_mv |
Garde-Etayo, Laura Trandafir, Paula Camelia Saint-Laurent, Céline Ugarte Martínez, María Dolores Insausti Serrano, Ana María |
| author |
Garde-Etayo, Laura |
| author_facet |
Garde-Etayo, Laura Trandafir, Paula Camelia Saint-Laurent, Céline Ugarte Martínez, María Dolores Insausti Serrano, Ana María |
| author_role |
author |
| author2 |
Trandafir, Paula Camelia Saint-Laurent, Céline Ugarte Martínez, María Dolores Insausti Serrano, Ana María |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Ciencias de la Salud Estadística, Informática y Matemáticas Osasun Zientziak Estatistika, Informatika eta Matematika Institute for Advanced Materials and Mathematics - INAMAT2 |
| dc.subject.none.fl_str_mv |
Achondroplasia Resting energy expenditure Obesity Indirect calorimetry Body composition |
| topic |
Achondroplasia Resting energy expenditure Obesity Indirect calorimetry Body composition |
| description |
Background: Persons with achondroplasia develop early obesity, which is a comorbidity associated with other complications. Currently, there are no validated specific predictive equations to estimate resting energy expenditure in achondroplasia. Methods: We analyzed the influence of body composition on this parameter and determined whether predictive models used for children with standard height are adjusted to achondroplasia. In this cross-sectional study, we measured anthropometric parameters in children with achondroplasia. Fat mass was obtained using the Slaughter skinfold-thickness equation and resting energy expenditure was determined with a Fitmate-Cosmed calorimeter and with predictive models validated for children with average height (Schofield, Institute of Medicine, and Tverskaya). Results: All of the equations yielded a lower mean value than resting energy expenditure with indirect calorimetry (1256±200 kcal/day [mean±SD]) but the closest was the Tverskaya equation (1017 ± 64 kcal/day), although the difference remained statistically significant. We conclude that weight and height have the greatest influence on resting energy expenditure. Conclusion: We recommend studying the relationship between body composition and energy expenditure in achondroplasia in more depth. In the absence of valid predictive models suitable for clinical use to estimate body composition and resting energy expenditure in achondroplasia, it is recommended to use the gold standard methods by taking into account certain anthropometric parameters. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2454/47339 |
| url |
https://hdl.handle.net/2454/47339 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
© 2023 The Authors. This is an open access article under the CC BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
© 2023 The Authors. This is an open access article under the CC BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra instname:Universidad Pública de Navarra |
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Universidad Pública de Navarra |
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Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
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Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
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