Exploring the Impact of Phenanthroline-Based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis-Related Processes
Novel water-soluble, phosphorescent ruthenium(II) polypyridyl-glycoconjugates of general formula [Ru{N-(1,10-phenanthroline)}2{N-(1,10-phenanthrolin-5-yl)-beta-glycopyranosylamine}][Cl]2 (glycopyranosyl = D-glucopyranosyl (1), D-mannopyranosyl (2), L-rhamnopyranosyl (3), L-xylopyranosyl (4), and 2,3...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/65763 |
| Acceso en línea: | http://hdl.handle.net/10017/65763 https://dx.doi.org/10.1002/chem.202501105 |
| Access Level: | acceso abierto |
| Palabra clave: | Antimetastatic Glycoconjugates Photodynamictherapy Photosensitizer Ruthenium(II) Polypyridyl Química Chemistry |
| Sumario: | Novel water-soluble, phosphorescent ruthenium(II) polypyridyl-glycoconjugates of general formula [Ru{N-(1,10-phenanthroline)}2{N-(1,10-phenanthrolin-5-yl)-beta-glycopyranosylamine}][Cl]2 (glycopyranosyl = D-glucopyranosyl (1), D-mannopyranosyl (2), L-rhamnopyranosyl (3), L-xylopyranosyl (4), and 2,3,4-tri-O-acetyl-L-xylopyranosyl (5)) and corresponding aglycone [Ru{N-(1,10-phenanthroline)}2{N-(1,10-phenanthrolin-5-amine)}][Cl]2 (6) have been synthesized and fully characterized. Their stability and behavior in physiological media have been assessed using ultraviolet visible spectroscopy (UV-Vis) and 1H nuclear magnetic resonance (H-1-NMR), revealing minor N-glycosidic cleavage and high photostability. The photocytotoxicity of the complexes has been evaluated in two different cancer (PC-3 and MCF-7) and one nontumorigenic (HFF-1) cell lines. While exhibiting no toxicity in the dark, some glycoconjugates achieve photoselectivity indexes of up to 40 upon blue-light irradiation. Remarkably, complexes 1-6 potently affect the metastatic phenotype of PC-3 cells, evidenced by the inhibition of migration in the wound healing assay and the increased resistance to trypsin detachment following photoactivation. |
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