Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index

FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The...

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Autores: Pardo, María, Crujeiras, Ana B., Amil, María, Agüera, Zaida, Jiménez-Murcia, Susana, Baños Rivera, Rosa María, Botella Arbona, Cristina, Torre Fornell, Rafael de la, Estivill, Xavier, 1955-, Fagundo, Ana Beatriz, Fernández-Real Lemos, José Manuel, Fernández García, José C., Fruhbeck, Gema, Gómez Ambrosi, Javier, Rodríguez, Roser, Tinahones, Francisco J., Fernández Aranda, Fernando, Casanueva, Felipe F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124355
Acceso en línea:https://hdl.handle.net/2445/124355
Access Level:acceso abierto
Palabra clave:Obesitat
Diabetis
Obesity
Diabetes
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spelling Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass IndexPardo, MaríaCrujeiras, Ana B.Amil, MaríaAgüera, ZaidaJiménez-Murcia, SusanaBaños Rivera, Rosa MaríaBotella Arbona, CristinaTorre Fornell, Rafael de laEstivill, Xavier, 1955-Fagundo, Ana BeatrizFernández-Real Lemos, José ManuelFernández García, José C.Fruhbeck, GemaGómez Ambrosi, JavierRodríguez, RoserTinahones, Francisco J.Fernández Aranda, FernandoCasanueva, Felipe F.ObesitatDiabetisObesityDiabetesFNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.Hindawi Ltd2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/124355Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1155/2014/857270International Journal of Endocrinology, 2014, vol. 2014https://doi.org/10.1155/2014/857270cc by (c) Pardo et al., 2014http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1243552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
title Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
spellingShingle Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
Pardo, María
Obesitat
Diabetis
Obesity
Diabetes
title_short Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
title_full Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
title_fullStr Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
title_full_unstemmed Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
title_sort Association Of Irisin With Fat Mass, Resting Energy Expenditure, And Daily Activity In Conditions Of Extreme Body Mass Index
dc.creator.none.fl_str_mv Pardo, María
Crujeiras, Ana B.
Amil, María
Agüera, Zaida
Jiménez-Murcia, Susana
Baños Rivera, Rosa María
Botella Arbona, Cristina
Torre Fornell, Rafael de la
Estivill, Xavier, 1955-
Fagundo, Ana Beatriz
Fernández-Real Lemos, José Manuel
Fernández García, José C.
Fruhbeck, Gema
Gómez Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández Aranda, Fernando
Casanueva, Felipe F.
author Pardo, María
author_facet Pardo, María
Crujeiras, Ana B.
Amil, María
Agüera, Zaida
Jiménez-Murcia, Susana
Baños Rivera, Rosa María
Botella Arbona, Cristina
Torre Fornell, Rafael de la
Estivill, Xavier, 1955-
Fagundo, Ana Beatriz
Fernández-Real Lemos, José Manuel
Fernández García, José C.
Fruhbeck, Gema
Gómez Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández Aranda, Fernando
Casanueva, Felipe F.
author_role author
author2 Crujeiras, Ana B.
Amil, María
Agüera, Zaida
Jiménez-Murcia, Susana
Baños Rivera, Rosa María
Botella Arbona, Cristina
Torre Fornell, Rafael de la
Estivill, Xavier, 1955-
Fagundo, Ana Beatriz
Fernández-Real Lemos, José Manuel
Fernández García, José C.
Fruhbeck, Gema
Gómez Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández Aranda, Fernando
Casanueva, Felipe F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Diabetis
Obesity
Diabetes
topic Obesitat
Diabetis
Obesity
Diabetes
description FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
publishDate 2014
dc.date.none.fl_str_mv 2014
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124355
url https://hdl.handle.net/2445/124355
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1155/2014/857270
International Journal of Endocrinology, 2014, vol. 2014
https://doi.org/10.1155/2014/857270
dc.rights.none.fl_str_mv cc by (c) Pardo et al., 2014
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Pardo et al., 2014
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Hindawi Ltd
publisher.none.fl_str_mv Hindawi Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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