Assessing effectiveness of colonic and gynecological risk reducing surgery in lynch syndrome individuals

Background: Colorectal (CRC) and endometrial cancer (EC) are the most common types of cancer in Lynch syndrome (LS). Risk reducing surgeries (RRS) might impact cancer incidence and mortality. Our objectives were to evaluate cumulative incidences of CRC, gynecological cancer and all-cause mortality a...

Descripción completa

Detalles Bibliográficos
Autores: Dueñas, Nuria, Navarro, Matilde, Teulé-Vega, Àlex, Solanes, Ares, Salinas Masdeu, Mònica, Iglesias Casals, Sílvia, Munté, Elisabet, Ponce i Sebastià, Jordi, Guardiola, Jordi, Kreisler, Esther, Carballas, Elvira, Cuadrado, Marta, Matias-Guiu, Xavier, 1958-, Ossa, Napoleón de la, Lop, Joan, Lázaro García, Conxi, Capellá, G. (Gabriel), Pineda Riu, Marta, Brunet, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172568
Acceso en línea:https://hdl.handle.net/2445/172568
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Càncer d'endometri
Càncer ginecològic
Càncer d'ovari
Colorectal cancer
Endometrial cancer
Gynecologic cancer
Ovarian cancer
Descripción
Sumario:Background: Colorectal (CRC) and endometrial cancer (EC) are the most common types of cancer in Lynch syndrome (LS). Risk reducing surgeries (RRS) might impact cancer incidence and mortality. Our objectives were to evaluate cumulative incidences of CRC, gynecological cancer and all-cause mortality after RRS in LS individuals. Methods: retrospective analysis of 976 LS carriers from a single-institution registry. Primary endpoints were cumulative incidence at 75 years of cancer (metachronous CRC in 425 individuals; EC and ovarian cancer (OC) in 531 individuals) and all-cause mortality cumulative incidence, comparing extended (ES) vs. segmental surgery (SS) in the CRC cohort and risk reducing gynecological surgery (RRGS) vs. surveillance in the gynecological cohort. Results: cumulative incidence at 75 years of metachronous CRC was 12.5% vs. 44.7% (p = 0.04) and all-cause mortality cumulative incidence was 38.6% vs. 55.3% (p = 0.31), for ES and SS, respectively. Cumulative, incidence at 75 years was 11.2% vs. 46.3% for EC (p = 0.001) and 0% vs. 12.7% for OC (p N/A) and all-cause mortality cumulative incidence was 0% vs. 52.7% (p N/A), for RRGS vs. surveillance, respectively. Conclusions: RRS in LS reduces the incidence of metachronous CRC and gynecological neoplasms, also indicating a reduction in all-cause mortality cumulative incidence in females undergoing RRGS.

Similares en LA Referencia