Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico

BACKGROUND: Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE: To describ...

Full description

Bibliographic Details
Authors: Gamiño-Arroyo, Ana Estela, Moreno-Espinosa, Sarbelio, Llamosas-Gallardo, Beatriz, Ortiz-Hernández, Ana A, Guerrero, M Lourdes, Galindo-Fraga, Arturo, Galán-Herrera, Juan F, Prado-Galbarro, Francisco Javier, Beigel, John H, Ruiz-Palacios, Guillermo M, Noyola, Daniel E
Format: article
Publication Date:2017
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/9774
Online Access:http://hdl.handle.net/20.500.12105/9774
Access Level:Open access
Keyword:Acute Disease
Adolescent
Adult
Child
Child, Preschool
Coinfection
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Male
Mexico
Middle Aged
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Young Adult
id ES_938f16da2ebe7311106edcb95ef79bfa
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/9774
network_acronym_str ES
network_name_str España
repository_id_str
spelling Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in MexicoGamiño-Arroyo, Ana EstelaMoreno-Espinosa, SarbelioLlamosas-Gallardo, BeatrizOrtiz-Hernández, Ana AGuerrero, M LourdesGalindo-Fraga, ArturoGalán-Herrera, Juan FPrado-Galbarro, Francisco JavierBeigel, John HRuiz-Palacios, Guillermo MNoyola, Daniel EAcute DiseaseAdolescentAdultChildChild, PreschoolCoinfectionFemaleHospitalizationHumansInfantInfant, NewbornInfluenza, HumanMaleMexicoMiddle AgedRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanRespiratory Tract InfectionsYoung AdultBACKGROUND: Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE: To describe the epidemiology of RSV infection and to analyze the factors associated with severe infections in children and adults in Mexico. METHODS: Patients ≥1 month old, who presented with an influenza-like illness (ILI) to six hospitals in Mexico, were eligible for participation in the study. Multiplex reverse-transcriptase polymerase chain reaction identified viral pathogens in nasal swabs from 5629 episodes of ILI. Patients in whom RSV was detected were included in this report. RESULTS: Respiratory syncytial virus was detected in 399 children and 171 adults. RSV A was detected in 413 cases and RSV B in 163, including six patients who had coinfection with both subtypes; 414 (72.6%) patients required hospital admission, including 96 (16.8%) patients that required admission to the intensive care unit. Coinfection with one or more respiratory pathogens other than RSV was detected in 159 cases. Young age (in children) and older age (in adults) as well as the presence of some underlying conditions were associated with more severe disease. CONCLUSIONS: This study confirms that RSV is an important respiratory pathogen in children in Mexico. In addition, a substantial number of cases in adults were also detected highlighting the relevance of this virus in all ages. It is important to identify subjects at high risk of complications who may benefit from current or future preventive interventions.WileyNIH - National Cancer Institute (NCI) (Estados Unidos)NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)Consejo Nacional de Ciencia y Tecnología (México)20202020-04-2820172017-01-0120172017-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/9774reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/97742026-06-12T12:43:37Z
dc.title.none.fl_str_mv Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
title Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
spellingShingle Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
Gamiño-Arroyo, Ana Estela
Acute Disease
Adolescent
Adult
Child
Child, Preschool
Coinfection
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Male
Mexico
Middle Aged
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Young Adult
title_short Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
title_full Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
title_fullStr Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
title_full_unstemmed Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
title_sort Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico
dc.creator.none.fl_str_mv Gamiño-Arroyo, Ana Estela
Moreno-Espinosa, Sarbelio
Llamosas-Gallardo, Beatriz
Ortiz-Hernández, Ana A
Guerrero, M Lourdes
Galindo-Fraga, Arturo
Galán-Herrera, Juan F
Prado-Galbarro, Francisco Javier
Beigel, John H
Ruiz-Palacios, Guillermo M
Noyola, Daniel E
author Gamiño-Arroyo, Ana Estela
author_facet Gamiño-Arroyo, Ana Estela
Moreno-Espinosa, Sarbelio
Llamosas-Gallardo, Beatriz
Ortiz-Hernández, Ana A
Guerrero, M Lourdes
Galindo-Fraga, Arturo
Galán-Herrera, Juan F
Prado-Galbarro, Francisco Javier
Beigel, John H
Ruiz-Palacios, Guillermo M
Noyola, Daniel E
author_role author
author2 Moreno-Espinosa, Sarbelio
Llamosas-Gallardo, Beatriz
Ortiz-Hernández, Ana A
Guerrero, M Lourdes
Galindo-Fraga, Arturo
Galán-Herrera, Juan F
Prado-Galbarro, Francisco Javier
Beigel, John H
Ruiz-Palacios, Guillermo M
Noyola, Daniel E
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NIH - National Cancer Institute (NCI) (Estados Unidos)
NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)
Consejo Nacional de Ciencia y Tecnología (México)
dc.subject.none.fl_str_mv Acute Disease
Adolescent
Adult
Child
Child, Preschool
Coinfection
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Male
Mexico
Middle Aged
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Young Adult
topic Acute Disease
Adolescent
Adult
Child
Child, Preschool
Coinfection
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Male
Mexico
Middle Aged
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Young Adult
description BACKGROUND: Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE: To describe the epidemiology of RSV infection and to analyze the factors associated with severe infections in children and adults in Mexico. METHODS: Patients ≥1 month old, who presented with an influenza-like illness (ILI) to six hospitals in Mexico, were eligible for participation in the study. Multiplex reverse-transcriptase polymerase chain reaction identified viral pathogens in nasal swabs from 5629 episodes of ILI. Patients in whom RSV was detected were included in this report. RESULTS: Respiratory syncytial virus was detected in 399 children and 171 adults. RSV A was detected in 413 cases and RSV B in 163, including six patients who had coinfection with both subtypes; 414 (72.6%) patients required hospital admission, including 96 (16.8%) patients that required admission to the intensive care unit. Coinfection with one or more respiratory pathogens other than RSV was detected in 159 cases. Young age (in children) and older age (in adults) as well as the presence of some underlying conditions were associated with more severe disease. CONCLUSIONS: This study confirms that RSV is an important respiratory pathogen in children in Mexico. In addition, a substantial number of cases in adults were also detected highlighting the relevance of this virus in all ages. It is important to identify subjects at high risk of complications who may benefit from current or future preventive interventions.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
2017
2017-01-01
2020
2020-04-28
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/9774
url http://hdl.handle.net/20.500.12105/9774
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413607443267584
score 15.812455

Similar Items