Keto-Enol Tautomerism in Passerini and Ugi Adducts
The use of arylglyoxal as starting material in Passerini and Ugi reactions affords βketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 position affects such tautomerism, and to investiga...
| Autores: | , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2021 |
| País: | España |
| Recursos: | Universidad de Burgos (UBU) |
| Repositório: | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| OAI Identifier: | oai:riubu.ubu.es:10259/8613 |
| Acesso em linha: | http://hdl.handle.net/10259/8613 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Keto-enol tautomerism Passerini adduct Ugi adduct Lactone Lactame 2-hydroxyglutaric acid Química orgánica Chemistry, Organic |
| Resumo: | The use of arylglyoxal as starting material in Passerini and Ugi reactions affords βketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 position affects such tautomerism, and to investigate the reactivity of both the enol and carbonyl forms. In this work we also prove the versatility of the Passerini reaction, since depending on the conditions to which the corresponding adducts are subjected different products of synthetic interest can be obtained. |
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