Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex

[EN]In the past few years accumulating evidence involved chromosomal instability and the subsequent aneuploidy that it generates in tumor formation. Moreover, the misregulation of most of the proteins involved in the mitotic checkpoint as well as kinetochore assembly has proven to have tumorigenic p...

Descripción completa

Detalles Bibliográficos
Autor: Díaz Rodríguez, María Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/167953
Acceso en línea:http://hdl.handle.net/10366/167953
Access Level:acceso abierto
Palabra clave:Ndc80
Hec1,
Kinetochore
spindle checkpoint
Aneuploidy
Cancer
2302 Bioquímica
id ES_936d76b60d4a01a23c36bb50f62da368
oai_identifier_str oai:gredos.usal.es:10366/167953
network_acronym_str ES
network_name_str España
repository_id_str
spelling Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 ComplexDíaz Rodríguez, María ElenaNdc80Hec1,Kinetochorespindle checkpointAneuploidyCancer2302 Bioquímica[EN]In the past few years accumulating evidence involved chromosomal instability and the subsequent aneuploidy that it generates in tumor formation. Moreover, the misregulation of most of the proteins involved in the mitotic checkpoint as well as kinetochore assembly has proven to have tumorigenic potential in vivo. Thus, the overexpression of Ndc80/Hec1, an outer kinetochore protein involved in spindle assembly checkpoint (SAC) recruitment, has been shown to induce tumor formation in different organs. Since Ndc80/Hec1 is a protein "highly expressed in cancer", it is an attractive target that can be used for cancer therapy. In this direction, several strategies aiming to in vivo block this complex structure and activity are being developed, and some of them have demonstrated to have tumor growth inhibition potential. These therapies represent a potential interesting approach for the treatment of malignancies where Ndc80/Hec1 expression is upregulated. Here we will discuss different aspects of Ndc80/Hec1 biology, its role in kinetochore assembly and spindle checkpoint, and its importance as a potential therapeutical target.Benthamdirect202520252010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/167953reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésSAN196/SA04/07SAN673/SA41/08FS/18-2008Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1679532026-06-07T06:28:51Z
dc.title.none.fl_str_mv Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
title Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
spellingShingle Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
Díaz Rodríguez, María Elena
Ndc80
Hec1,
Kinetochore
spindle checkpoint
Aneuploidy
Cancer
2302 Bioquímica
title_short Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
title_full Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
title_fullStr Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
title_full_unstemmed Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
title_sort Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex
dc.creator.none.fl_str_mv Díaz Rodríguez, María Elena
author Díaz Rodríguez, María Elena
author_facet Díaz Rodríguez, María Elena
author_role author
dc.subject.none.fl_str_mv Ndc80
Hec1,
Kinetochore
spindle checkpoint
Aneuploidy
Cancer
2302 Bioquímica
topic Ndc80
Hec1,
Kinetochore
spindle checkpoint
Aneuploidy
Cancer
2302 Bioquímica
description [EN]In the past few years accumulating evidence involved chromosomal instability and the subsequent aneuploidy that it generates in tumor formation. Moreover, the misregulation of most of the proteins involved in the mitotic checkpoint as well as kinetochore assembly has proven to have tumorigenic potential in vivo. Thus, the overexpression of Ndc80/Hec1, an outer kinetochore protein involved in spindle assembly checkpoint (SAC) recruitment, has been shown to induce tumor formation in different organs. Since Ndc80/Hec1 is a protein "highly expressed in cancer", it is an attractive target that can be used for cancer therapy. In this direction, several strategies aiming to in vivo block this complex structure and activity are being developed, and some of them have demonstrated to have tumor growth inhibition potential. These therapies represent a potential interesting approach for the treatment of malignancies where Ndc80/Hec1 expression is upregulated. Here we will discuss different aspects of Ndc80/Hec1 biology, its role in kinetochore assembly and spindle checkpoint, and its importance as a potential therapeutical target.
publishDate 2010
dc.date.none.fl_str_mv 2010
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/167953
url http://hdl.handle.net/10366/167953
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SAN196/SA04/07
SAN673/SA41/08
FS/18-2008
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Benthamdirect
publisher.none.fl_str_mv Benthamdirect
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413596269641728
score 15,811543

Similares en LA Referencia