Excipients in the Paediatric Population: A Review

This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric medicin...

Descripción completa

Detalles Bibliográficos
Autores: Rouaz El Hajoui, Khadija, Chiclana Rodríguez, Blanca, Nardi Ricart, Anna, Suñé Pou, Marc, Mercadé Frutos, Débora, Suñé i Negre, Josep M. (Josep Maria), Pérez Lozano, Pilar, García Montoya, Encarna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176690
Acceso en línea:https://hdl.handle.net/2445/176690
Access Level:acceso abierto
Palabra clave:Excipients
Pediatria
Toxicologia pediàtrica
Medicaments
Pediatrics
Pediatric toxicology
Drugs
id ES_935dc44121dcd28b75464d5ca777bcfd
oai_identifier_str oai:diposit.ub.edu:2445/176690
network_acronym_str ES
network_name_str España
repository_id_str
spelling Excipients in the Paediatric Population: A ReviewRouaz El Hajoui, KhadijaChiclana Rodríguez, BlancaNardi Ricart, AnnaSuñé Pou, MarcMercadé Frutos, DéboraSuñé i Negre, Josep M. (Josep Maria)Pérez Lozano, PilarGarcía Montoya, EncarnaExcipientsPediatriaToxicologia pediàtricaMedicamentsExcipientsPediatricsPediatric toxicologyDrugsThis theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric medicine formulations, identifying the compounds that scientific literature has marked as potentially harmful regarding the side effects generated after exposure. On the other hand, this review also highlights the importance of carrying out safety -checks on the excipients, which, in most cases, are linked to toxicity studies. An excipient in the compilation of paediatric population databases is expected to target safety and toxicity, as in the STEP database. Finally, a promising pharmaceutical form for child population, ODT (Orally Disintegrating Tablets), will be studied.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176690Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13030387Pharmaceutics, 2021, vol. 13, num. 3, p. 387cc-by (c) Rouaz, Khadija et al., 2021http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1766902026-05-27T06:46:51Z
dc.title.none.fl_str_mv Excipients in the Paediatric Population: A Review
title Excipients in the Paediatric Population: A Review
spellingShingle Excipients in the Paediatric Population: A Review
Rouaz El Hajoui, Khadija
Excipients
Pediatria
Toxicologia pediàtrica
Medicaments
Excipients
Pediatrics
Pediatric toxicology
Drugs
title_short Excipients in the Paediatric Population: A Review
title_full Excipients in the Paediatric Population: A Review
title_fullStr Excipients in the Paediatric Population: A Review
title_full_unstemmed Excipients in the Paediatric Population: A Review
title_sort Excipients in the Paediatric Population: A Review
dc.creator.none.fl_str_mv Rouaz El Hajoui, Khadija
Chiclana Rodríguez, Blanca
Nardi Ricart, Anna
Suñé Pou, Marc
Mercadé Frutos, Débora
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
author Rouaz El Hajoui, Khadija
author_facet Rouaz El Hajoui, Khadija
Chiclana Rodríguez, Blanca
Nardi Ricart, Anna
Suñé Pou, Marc
Mercadé Frutos, Débora
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
author_role author
author2 Chiclana Rodríguez, Blanca
Nardi Ricart, Anna
Suñé Pou, Marc
Mercadé Frutos, Débora
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Excipients
Pediatria
Toxicologia pediàtrica
Medicaments
Excipients
Pediatrics
Pediatric toxicology
Drugs
topic Excipients
Pediatria
Toxicologia pediàtrica
Medicaments
Excipients
Pediatrics
Pediatric toxicology
Drugs
description This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric medicine formulations, identifying the compounds that scientific literature has marked as potentially harmful regarding the side effects generated after exposure. On the other hand, this review also highlights the importance of carrying out safety -checks on the excipients, which, in most cases, are linked to toxicity studies. An excipient in the compilation of paediatric population databases is expected to target safety and toxicity, as in the STEP database. Finally, a promising pharmaceutical form for child population, ODT (Orally Disintegrating Tablets), will be studied.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176690
url https://hdl.handle.net/2445/176690
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13030387
Pharmaceutics, 2021, vol. 13, num. 3, p. 387
dc.rights.none.fl_str_mv cc-by (c) Rouaz, Khadija et al., 2021
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rouaz, Khadija et al., 2021
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413575617937408
score 15.300719

Similares en LA Referencia