Epigenomes in Cardiovascular Disease

If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental di...

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Detalles Bibliográficos
Autores: Rosa-Garrido, Manuel, Chapski, Douglas J., Vondriska, Thomas M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/414527
Acceso en línea:http://hdl.handle.net/10261/414527
https://api.elsevier.com/content/abstract/scopus_id/85053444955
Access Level:acceso abierto
Palabra clave:Cardiovascular diseases
Chromatin
Epigenomics
Genetics
Transcriptome
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spelling Epigenomes in Cardiovascular DiseaseRosa-Garrido, ManuelChapski, Douglas J.Vondriska, Thomas M.Cardiovascular diseasesChromatinEpigenomicsGeneticsTranscriptomeIf unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies.Peer reviewedAmerican Heart Association202620262018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/414527https://api.elsevier.com/content/abstract/scopus_id/85053444955reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1161/CIRCRESAHA.118.311597Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4145272026-05-22T06:33:51Z
dc.title.none.fl_str_mv Epigenomes in Cardiovascular Disease
title Epigenomes in Cardiovascular Disease
spellingShingle Epigenomes in Cardiovascular Disease
Rosa-Garrido, Manuel
Cardiovascular diseases
Chromatin
Epigenomics
Genetics
Transcriptome
title_short Epigenomes in Cardiovascular Disease
title_full Epigenomes in Cardiovascular Disease
title_fullStr Epigenomes in Cardiovascular Disease
title_full_unstemmed Epigenomes in Cardiovascular Disease
title_sort Epigenomes in Cardiovascular Disease
dc.creator.none.fl_str_mv Rosa-Garrido, Manuel
Chapski, Douglas J.
Vondriska, Thomas M.
author Rosa-Garrido, Manuel
author_facet Rosa-Garrido, Manuel
Chapski, Douglas J.
Vondriska, Thomas M.
author_role author
author2 Chapski, Douglas J.
Vondriska, Thomas M.
author2_role author
author
dc.subject.none.fl_str_mv Cardiovascular diseases
Chromatin
Epigenomics
Genetics
Transcriptome
topic Cardiovascular diseases
Chromatin
Epigenomics
Genetics
Transcriptome
description If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies.
publishDate 2018
dc.date.none.fl_str_mv 2018
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/414527
https://api.elsevier.com/content/abstract/scopus_id/85053444955
url http://hdl.handle.net/10261/414527
https://api.elsevier.com/content/abstract/scopus_id/85053444955
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1161/CIRCRESAHA.118.311597
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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