Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells

Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and...

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Autores: Muñoz-Cano, Rosa, San Bartolome, Clara, Casas Saucedo, Rocio, Araujo Sánchez, Giovanna, Gelis, Sònia, Ruano Zaragoza, Maria, Roca i Ferrer, Jordi, Palomares, Francis, Martín Andorrà, Margarita, Bartra Tomàs, Joan, Pascal i Capdevila, Mariona
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178365
Acceso en línea:https://hdl.handle.net/2445/178365
Access Level:acceso abierto
Palabra clave:Al·lèrgia alimentària
Immunologia
Food allergy
Immunology
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spelling Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast CellsMuñoz-Cano, RosaSan Bartolome, ClaraCasas Saucedo, RocioAraujo Sánchez, GiovannaGelis, SòniaRuano Zaragoza, MariaRoca i Ferrer, JordiPalomares, FrancisMartín Andorrà, MargaritaBartra Tomàs, JoanPascal i Capdevila, MarionaAl·lèrgia alimentàriaImmunologiaFood allergyImmunologyCofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and alcohol are the most frequently described, although the underlying mechanisms are poorly known. Several hypotheses have suggested the influence of these cofactors on basophils and mast cells (MCs). Exercise has been suggested to enhance MC activation by increasing plasma osmolarity, redistributing blood flow, and activating adenosine and eicosanoid metabolism. NSAIDs' cofactor effect has been related with cyclooxygenase inhibition and therefore, prostaglandin E2 (PGE2) production. Indeed, overexpression of adenosine receptor 3 (A3) gene has been described in NSAID-dependent FAn; A3 activation potentiates FcϵRI-induced MC degranulation. Finally, alcohol has been related with an increase of histamine levels by inhibition of diamino oxidase (DAO) and also with and increase of extracellular adenosine by inhibition of its uptake. However, most of these mechanisms have limited evidence, and further studies are urgently needed. In conclusion, the study of the immune-related mechanisms involved in food allergic reactions enhanced by cofactors is of the utmost interest. This knowledge will help to design both tailored treatments and prophylactic strategies that, nowadays, are non-existent.Frontiers Media2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/178365Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.623071Frontiers in Immunology, 2021, vol. 11https://doi.org/10.3389/fimmu.2020.623071cc-by (c) Muñoz Cano, Rosa Maria et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1783652026-05-29T05:05:01Z
dc.title.none.fl_str_mv Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
title Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
spellingShingle Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
Muñoz-Cano, Rosa
Al·lèrgia alimentària
Immunologia
Food allergy
Immunology
title_short Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
title_full Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
title_fullStr Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
title_full_unstemmed Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
title_sort Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
dc.creator.none.fl_str_mv Muñoz-Cano, Rosa
San Bartolome, Clara
Casas Saucedo, Rocio
Araujo Sánchez, Giovanna
Gelis, Sònia
Ruano Zaragoza, Maria
Roca i Ferrer, Jordi
Palomares, Francis
Martín Andorrà, Margarita
Bartra Tomàs, Joan
Pascal i Capdevila, Mariona
author Muñoz-Cano, Rosa
author_facet Muñoz-Cano, Rosa
San Bartolome, Clara
Casas Saucedo, Rocio
Araujo Sánchez, Giovanna
Gelis, Sònia
Ruano Zaragoza, Maria
Roca i Ferrer, Jordi
Palomares, Francis
Martín Andorrà, Margarita
Bartra Tomàs, Joan
Pascal i Capdevila, Mariona
author_role author
author2 San Bartolome, Clara
Casas Saucedo, Rocio
Araujo Sánchez, Giovanna
Gelis, Sònia
Ruano Zaragoza, Maria
Roca i Ferrer, Jordi
Palomares, Francis
Martín Andorrà, Margarita
Bartra Tomàs, Joan
Pascal i Capdevila, Mariona
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Al·lèrgia alimentària
Immunologia
Food allergy
Immunology
topic Al·lèrgia alimentària
Immunologia
Food allergy
Immunology
description Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and alcohol are the most frequently described, although the underlying mechanisms are poorly known. Several hypotheses have suggested the influence of these cofactors on basophils and mast cells (MCs). Exercise has been suggested to enhance MC activation by increasing plasma osmolarity, redistributing blood flow, and activating adenosine and eicosanoid metabolism. NSAIDs' cofactor effect has been related with cyclooxygenase inhibition and therefore, prostaglandin E2 (PGE2) production. Indeed, overexpression of adenosine receptor 3 (A3) gene has been described in NSAID-dependent FAn; A3 activation potentiates FcϵRI-induced MC degranulation. Finally, alcohol has been related with an increase of histamine levels by inhibition of diamino oxidase (DAO) and also with and increase of extracellular adenosine by inhibition of its uptake. However, most of these mechanisms have limited evidence, and further studies are urgently needed. In conclusion, the study of the immune-related mechanisms involved in food allergic reactions enhanced by cofactors is of the utmost interest. This knowledge will help to design both tailored treatments and prophylactic strategies that, nowadays, are non-existent.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178365
url https://hdl.handle.net/2445/178365
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.623071
Frontiers in Immunology, 2021, vol. 11
https://doi.org/10.3389/fimmu.2020.623071
dc.rights.none.fl_str_mv cc-by (c) Muñoz Cano, Rosa Maria et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Muñoz Cano, Rosa Maria et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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