Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper

Pascal i Capdevila, Mariona; Bax, Heather J.; Bergmann, Christoph; Bianchini, Rodolfo; Castells, Mariana; Chauhan, Jitesh; Vecillas, Leticia de las; Hartmann, Karin; Izquierdo, Elena; Jappe, Uta; Jimenez Rodriguez, Teodorikez Wilfox; Knol, Edward; Levi-Schaffer, Francesca; Mayorga, Cristobalina; Poli, Aurélie; Redegeld, Frank; Santos, Alexandra F.; Jensen Jarolim, Erika; Karagiannis, Sophia N.

Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper

Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also e...

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Autores:	Pascal i Capdevila, Mariona, Bax, Heather J., Bergmann, Christoph, Bianchini, Rodolfo, Castells, Mariana, Chauhan, Jitesh, Vecillas, Leticia de las, Hartmann, Karin, Izquierdo, Elena, Jappe, Uta, Jimenez Rodriguez, Teodorikez Wilfox, Knol, Edward, Levi-Schaffer, Francesca, Mayorga, Cristobalina, Poli, Aurélie, Redegeld, Frank, Santos, Alexandra F., Jensen Jarolim, Erika, Karagiannis, Sophia N.
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Recursos:	Universidad de Oviedo (UNIOVI)
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:dnet:ubarcelona__::d2bf56d542f08b50aef50ec451122fe3
Acesso em linha:	https://hdl.handle.net/2445/229354
Access Level:	acceso abierto
Palavra-chave:	Cèl·lules canceroses Hematopoesi Al·lèrgia Cancer cells Hematopoiesis Allergy

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spelling	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paperPascal i Capdevila, MarionaBax, Heather J.Bergmann, ChristophBianchini, RodolfoCastells, MarianaChauhan, JiteshVecillas, Leticia de lasHartmann, KarinIzquierdo, ElenaJappe, UtaJimenez Rodriguez, Teodorikez WilfoxKnol, EdwardLevi-Schaffer, FrancescaMayorga, CristobalinaPoli, AurélieRedegeld, FrankSantos, Alexandra F.Jensen Jarolim, ErikaKaragiannis, Sophia N.Cèl·lules cancerosesHematopoesiAl·lèrgiaCancer cellsHematopoiesisAllergyDerived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.John Wiley & Sons2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/229354Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1111/all.16246Allergy, 2024, vol. 79, num. 9, p. 2319-2345https://doi.org/10.1111/all.16246cc-by-nc-nd (c) Pascal i Capdevila, Mariona et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::d2bf56d542f08b50aef50ec451122fe32026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
title	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
spellingShingle	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper Pascal i Capdevila, Mariona Cèl·lules canceroses Hematopoesi Al·lèrgia Cancer cells Hematopoiesis Allergy
title_short	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
title_full	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
title_fullStr	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
title_full_unstemmed	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
title_sort	Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper
dc.creator.none.fl_str_mv	Pascal i Capdevila, Mariona Bax, Heather J. Bergmann, Christoph Bianchini, Rodolfo Castells, Mariana Chauhan, Jitesh Vecillas, Leticia de las Hartmann, Karin Izquierdo, Elena Jappe, Uta Jimenez Rodriguez, Teodorikez Wilfox Knol, Edward Levi-Schaffer, Francesca Mayorga, Cristobalina Poli, Aurélie Redegeld, Frank Santos, Alexandra F. Jensen Jarolim, Erika Karagiannis, Sophia N.
author	Pascal i Capdevila, Mariona
author_facet	Pascal i Capdevila, Mariona Bax, Heather J. Bergmann, Christoph Bianchini, Rodolfo Castells, Mariana Chauhan, Jitesh Vecillas, Leticia de las Hartmann, Karin Izquierdo, Elena Jappe, Uta Jimenez Rodriguez, Teodorikez Wilfox Knol, Edward Levi-Schaffer, Francesca Mayorga, Cristobalina Poli, Aurélie Redegeld, Frank Santos, Alexandra F. Jensen Jarolim, Erika Karagiannis, Sophia N.
author_role	author
author2	Bax, Heather J. Bergmann, Christoph Bianchini, Rodolfo Castells, Mariana Chauhan, Jitesh Vecillas, Leticia de las Hartmann, Karin Izquierdo, Elena Jappe, Uta Jimenez Rodriguez, Teodorikez Wilfox Knol, Edward Levi-Schaffer, Francesca Mayorga, Cristobalina Poli, Aurélie Redegeld, Frank Santos, Alexandra F. Jensen Jarolim, Erika Karagiannis, Sophia N.
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Cèl·lules canceroses Hematopoesi Al·lèrgia Cancer cells Hematopoiesis Allergy
topic	Cèl·lules canceroses Hematopoesi Al·lèrgia Cancer cells Hematopoiesis Allergy
description	Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.
publishDate	2024
dc.date.none.fl_str_mv	2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/229354
url	https://hdl.handle.net/2445/229354
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1111/all.16246 Allergy, 2024, vol. 79, num. 9, p. 2319-2345 https://doi.org/10.1111/all.16246
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Pascal i Capdevila, Mariona et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Pascal i Capdevila, Mariona et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	John Wiley & Sons
publisher.none.fl_str_mv	John Wiley & Sons
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Oviedo (UNIOVI)
instname_str	Universidad de Oviedo (UNIOVI)
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.811543

Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper

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