Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator

Gastric emptying plays a crucial role in the dissolution and absorption of oral drugs, particularly those with pH-dependent solubility, such as dipyridamole. This study evaluates the impact of gastric emptying kinetics on dipyridamole dissolution using a Gastrointestinal Simulator. A dynamic dissolu...

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Detalles Bibliográficos
Autores: Ruíz-Picazo, Alejandro, Jimenez, Luis, González-Álvarez, Marta, Reinoso, Oscar, González-Álvarez, Isabel, Bermejo Sanz, María del Val
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38909
Acceso en línea:https://hdl.handle.net/11000/38909
Access Level:acceso abierto
Palabra clave:dipyridamole
dissolution kinetics
gastric emptying
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spelling Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal SimulatorRuíz-Picazo, AlejandroJimenez, LuisGonzález-Álvarez, MartaReinoso, OscarGonzález-Álvarez, IsabelBermejo Sanz, María del Valdipyridamoledissolution kineticsgastric emptyingGastric emptying plays a crucial role in the dissolution and absorption of oral drugs, particularly those with pH-dependent solubility, such as dipyridamole. This study evaluates the impact of gastric emptying kinetics on dipyridamole dissolution using a Gastrointestinal Simulator. A dynamic dissolution model incorporating first-order and Weibull kinetics was applied to simulate different gastric emptying profiles. Results indicate that dissolution behavior is significantly influenced by the rate and pattern of gastric emptying, affecting drug solubility and potential bioavailability. The Weibull model provided a more flexible fit to experimental data, but the external control shows that significant differences exist between theorical and experimental gastric volumes. These findings highlight the importance of integrating physiologically relevant gastric emptying models into biopharmaceutical assessments to improve the prediction of in vivo drug performance. This approach could enhance the design of oral formulations by optimizing dissolution profiles for weak base drugs.SpringerDepartamentos de la UMH::Ingeniería202620262025info:eu-repo/semantics/articleapplication/pdf14application/pdfhttps://hdl.handle.net/11000/38909reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheEuskera10.1208/s12248-025-01110-0info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/389092026-05-27T13:36:21Z
dc.title.none.fl_str_mv Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
title Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
spellingShingle Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
Ruíz-Picazo, Alejandro
dipyridamole
dissolution kinetics
gastric emptying
title_short Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
title_full Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
title_fullStr Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
title_full_unstemmed Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
title_sort Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator
dc.creator.none.fl_str_mv Ruíz-Picazo, Alejandro
Jimenez, Luis
González-Álvarez, Marta
Reinoso, Oscar
González-Álvarez, Isabel
Bermejo Sanz, María del Val
author Ruíz-Picazo, Alejandro
author_facet Ruíz-Picazo, Alejandro
Jimenez, Luis
González-Álvarez, Marta
Reinoso, Oscar
González-Álvarez, Isabel
Bermejo Sanz, María del Val
author_role author
author2 Jimenez, Luis
González-Álvarez, Marta
Reinoso, Oscar
González-Álvarez, Isabel
Bermejo Sanz, María del Val
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Ingeniería
dc.subject.none.fl_str_mv dipyridamole
dissolution kinetics
gastric emptying
topic dipyridamole
dissolution kinetics
gastric emptying
description Gastric emptying plays a crucial role in the dissolution and absorption of oral drugs, particularly those with pH-dependent solubility, such as dipyridamole. This study evaluates the impact of gastric emptying kinetics on dipyridamole dissolution using a Gastrointestinal Simulator. A dynamic dissolution model incorporating first-order and Weibull kinetics was applied to simulate different gastric emptying profiles. Results indicate that dissolution behavior is significantly influenced by the rate and pattern of gastric emptying, affecting drug solubility and potential bioavailability. The Weibull model provided a more flexible fit to experimental data, but the external control shows that significant differences exist between theorical and experimental gastric volumes. These findings highlight the importance of integrating physiologically relevant gastric emptying models into biopharmaceutical assessments to improve the prediction of in vivo drug performance. This approach could enhance the design of oral formulations by optimizing dissolution profiles for weak base drugs.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38909
url https://hdl.handle.net/11000/38909
dc.language.none.fl_str_mv Euskera
language_invalid_str_mv Euskera
dc.relation.none.fl_str_mv 10.1208/s12248-025-01110-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
14
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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