Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori...

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Autores: Fernández de Larrea-Baz, Nerea, Castaño Vinyals, Gemma, Kogevinas, Manolis, Aragonés, Núria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34737
Acceso en línea:http://hdl.handle.net/10230/34737
http://dx.doi.org/10.3389/fmicb.2017.00888
Access Level:acceso abierto
Palabra clave:Helicobacteri pilòric
Helicobacter pylori
Bacterial infections
Chronic infection
Colorectal neoplasm
Multiplex serology
Non-infectious diseases
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spelling Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in SpainFernández de Larrea-Baz, NereaCastaño Vinyals, GemmaKogevinas, ManolisAragonés, NúriaHelicobacteri pilòricHelicobacter pyloriBacterial infectionsChronic infectionColorectal neoplasmMultiplex serologyNon-infectious diseasesBackground: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ≥4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagδ showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.Frontiers201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34737http://dx.doi.org/10.3389/fmicb.2017.00888reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFrontiers in Microbiology. 2017 May 29;8:888© 2017 Fernández de Larrea-Baz, Michel, Romero, Pérez-Gómez, Moreno, Martín, Dierssen-Sotos, Jiménez-Moleón, Castilla, Tardón, Ruiz, Peiró, Tejada, Chirlaque, Butt, Olmedo-Requena, Gómez-Acebo, Linares, Boldo, Castells, Pawlita, Castaño-Vinyals, Kogevinas, de Sanjosé, Pollán, del Campo, Waterboer and Aragonés. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/347372026-06-12T07:21:37Z
dc.title.none.fl_str_mv Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
spellingShingle Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Fernández de Larrea-Baz, Nerea
Helicobacteri pilòric
Helicobacter pylori
Bacterial infections
Chronic infection
Colorectal neoplasm
Multiplex serology
Non-infectious diseases
title_short Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_full Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_fullStr Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_full_unstemmed Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_sort Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
dc.creator.none.fl_str_mv Fernández de Larrea-Baz, Nerea
Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author Fernández de Larrea-Baz, Nerea
author_facet Fernández de Larrea-Baz, Nerea
Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author_role author
author2 Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author2_role author
author
author
dc.subject.none.fl_str_mv Helicobacteri pilòric
Helicobacter pylori
Bacterial infections
Chronic infection
Colorectal neoplasm
Multiplex serology
Non-infectious diseases
topic Helicobacteri pilòric
Helicobacter pylori
Bacterial infections
Chronic infection
Colorectal neoplasm
Multiplex serology
Non-infectious diseases
description Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ≥4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagδ showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34737
http://dx.doi.org/10.3389/fmicb.2017.00888
url http://hdl.handle.net/10230/34737
http://dx.doi.org/10.3389/fmicb.2017.00888
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Microbiology. 2017 May 29;8:888
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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