Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients
Background Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/204325 |
| Acceso en línea: | https://hdl.handle.net/2445/204325 |
| Access Level: | acceso abierto |
| Palabra clave: | Anticossos monoclonals Migranya Monoclonal antibodies Migraine |
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Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patientsMuñoz Vendrell, AlbertCampoy Diaz, SergioCaronna, EdoardoAlpuente, AliciaTorres Ferrus, MartaNieves Castellanos, CandelaOlivier, MarinaCampdelacreu i Fumadó, JaumePrat, JoanCamiña Muñiz, JavierMolina Martínez, Francisco JoséMínguez Olaondo, AneRuibal Salgado, MartaSantos Lasaosa, SoniaNavarro Pérez, María PilarMorollón, NoemíLópez Bravo, AlbaCano Sánchez, Luis MiguelGarcía Sánchez, Sonia MaríaGarcía Ull, JésicaRubio Flores, LauraGonzález Martínez, AliciaQuintas, SoniaEchavarría Íñiguez, AnaGil Luque, SendoaCastro Sánchez, María VictoriaAdell Ortega, VanesaGarcía Alhama, JessicaBerrocal Izquierdo, NuriaBelvís, RobertDíaz Insa, SamuelPozo Rosich, PatriciaHuerta Villanueva, MarianoAnticossos monoclonalsMigranyaMonoclonal antibodiesMigraineBackground Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe the safety and effectiveness of erenumab, galcanezumab and fremanezumab in migraine patients over 65 years old in real-life. Methods In this observational real-life study, a retrospective analysis of prospectively collected data from 18 different headache units in Spain was performed. Migraine patients who started treatment with any anti-CGRP monoclonal antibody after the age of 65 years were included. Primary endpoints were reduction in monthly migraine days after 6 months of treatment and the presence of adverse effects. Secondary endpoints were reductions in headache and medication intake frequencies by months 3 and 6, response rates, changes in patient-reported outcomes and reasons for discontinuation. As a subanalysis, reduction in monthly migraine days and proportion of adverse effects were also compared among the three monoclonal antibodies. Results A total of 162 patients were included, median age 68 years (range 65-87), 74.1% women. 42% had dyslipidaemia, 40.3% hypertension, 8% diabetes, and 6.2% previous cardiovascular ischaemic disease. The reduction in monthly migraine days at month 6 was 10.17.3 days. A total of 25.3% of patients presented adverse effects, all of them mild, with only two cases of blood pressure increase. Headache and medication intake frequencies were significantly reduced, and patient-reported outcomes were improved. The proportions of responders were 68%, 57%, 33% and 9% for reductions in monthly migraine days >= 30%,>= 50%,>= 75% and 100%, respectively. A total of 72.8% of patients continued with the treatment after 6 months. The reduction in migraine days was similar for the different anti-CGRP treatments, but fewer adverse effects were detected with fremanezumab (7.7%). Conclusions Anti-CGRP mAbs are safe and effective treatments in migraine patients over 65 years old in real-life clinical practice.Springer Science and Business Media LLC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/204325Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s10194-023-01585-2The Journal of Headache and Pain, 2023, vol. 24, num. 1https://doi.org/10.1186/s10194-023-01585-2cc by (c) Muñoz Vendrell, Albert et al, 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2043252026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| title |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| spellingShingle |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients Muñoz Vendrell, Albert Anticossos monoclonals Migranya Monoclonal antibodies Migraine |
| title_short |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| title_full |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| title_fullStr |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| title_full_unstemmed |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| title_sort |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients |
| dc.creator.none.fl_str_mv |
Muñoz Vendrell, Albert Campoy Diaz, Sergio Caronna, Edoardo Alpuente, Alicia Torres Ferrus, Marta Nieves Castellanos, Candela Olivier, Marina Campdelacreu i Fumadó, Jaume Prat, Joan Camiña Muñiz, Javier Molina Martínez, Francisco José Mínguez Olaondo, Ane Ruibal Salgado, Marta Santos Lasaosa, Sonia Navarro Pérez, María Pilar Morollón, Noemí López Bravo, Alba Cano Sánchez, Luis Miguel García Sánchez, Sonia María García Ull, Jésica Rubio Flores, Laura González Martínez, Alicia Quintas, Sonia Echavarría Íñiguez, Ana Gil Luque, Sendoa Castro Sánchez, María Victoria Adell Ortega, Vanesa García Alhama, Jessica Berrocal Izquierdo, Nuria Belvís, Robert Díaz Insa, Samuel Pozo Rosich, Patricia Huerta Villanueva, Mariano |
| author |
Muñoz Vendrell, Albert |
| author_facet |
Muñoz Vendrell, Albert Campoy Diaz, Sergio Caronna, Edoardo Alpuente, Alicia Torres Ferrus, Marta Nieves Castellanos, Candela Olivier, Marina Campdelacreu i Fumadó, Jaume Prat, Joan Camiña Muñiz, Javier Molina Martínez, Francisco José Mínguez Olaondo, Ane Ruibal Salgado, Marta Santos Lasaosa, Sonia Navarro Pérez, María Pilar Morollón, Noemí López Bravo, Alba Cano Sánchez, Luis Miguel García Sánchez, Sonia María García Ull, Jésica Rubio Flores, Laura González Martínez, Alicia Quintas, Sonia Echavarría Íñiguez, Ana Gil Luque, Sendoa Castro Sánchez, María Victoria Adell Ortega, Vanesa García Alhama, Jessica Berrocal Izquierdo, Nuria Belvís, Robert Díaz Insa, Samuel Pozo Rosich, Patricia Huerta Villanueva, Mariano |
| author_role |
author |
| author2 |
Campoy Diaz, Sergio Caronna, Edoardo Alpuente, Alicia Torres Ferrus, Marta Nieves Castellanos, Candela Olivier, Marina Campdelacreu i Fumadó, Jaume Prat, Joan Camiña Muñiz, Javier Molina Martínez, Francisco José Mínguez Olaondo, Ane Ruibal Salgado, Marta Santos Lasaosa, Sonia Navarro Pérez, María Pilar Morollón, Noemí López Bravo, Alba Cano Sánchez, Luis Miguel García Sánchez, Sonia María García Ull, Jésica Rubio Flores, Laura González Martínez, Alicia Quintas, Sonia Echavarría Íñiguez, Ana Gil Luque, Sendoa Castro Sánchez, María Victoria Adell Ortega, Vanesa García Alhama, Jessica Berrocal Izquierdo, Nuria Belvís, Robert Díaz Insa, Samuel Pozo Rosich, Patricia Huerta Villanueva, Mariano |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Anticossos monoclonals Migranya Monoclonal antibodies Migraine |
| topic |
Anticossos monoclonals Migranya Monoclonal antibodies Migraine |
| description |
Background Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe the safety and effectiveness of erenumab, galcanezumab and fremanezumab in migraine patients over 65 years old in real-life. Methods In this observational real-life study, a retrospective analysis of prospectively collected data from 18 different headache units in Spain was performed. Migraine patients who started treatment with any anti-CGRP monoclonal antibody after the age of 65 years were included. Primary endpoints were reduction in monthly migraine days after 6 months of treatment and the presence of adverse effects. Secondary endpoints were reductions in headache and medication intake frequencies by months 3 and 6, response rates, changes in patient-reported outcomes and reasons for discontinuation. As a subanalysis, reduction in monthly migraine days and proportion of adverse effects were also compared among the three monoclonal antibodies. Results A total of 162 patients were included, median age 68 years (range 65-87), 74.1% women. 42% had dyslipidaemia, 40.3% hypertension, 8% diabetes, and 6.2% previous cardiovascular ischaemic disease. The reduction in monthly migraine days at month 6 was 10.17.3 days. A total of 25.3% of patients presented adverse effects, all of them mild, with only two cases of blood pressure increase. Headache and medication intake frequencies were significantly reduced, and patient-reported outcomes were improved. The proportions of responders were 68%, 57%, 33% and 9% for reductions in monthly migraine days >= 30%,>= 50%,>= 75% and 100%, respectively. A total of 72.8% of patients continued with the treatment after 6 months. The reduction in migraine days was similar for the different anti-CGRP treatments, but fewer adverse effects were detected with fremanezumab (7.7%). Conclusions Anti-CGRP mAbs are safe and effective treatments in migraine patients over 65 years old in real-life clinical practice. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/204325 |
| url |
https://hdl.handle.net/2445/204325 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/s10194-023-01585-2 The Journal of Headache and Pain, 2023, vol. 24, num. 1 https://doi.org/10.1186/s10194-023-01585-2 |
| dc.rights.none.fl_str_mv |
cc by (c) Muñoz Vendrell, Albert et al, 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by (c) Muñoz Vendrell, Albert et al, 2023 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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Springer Science and Business Media LLC |
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Springer Science and Business Media LLC |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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