Cajal’s organization of neuronal nucleus revisited

In 1906, Cajal was awarded the Nobel Prize in Physiology or Medicine for his pioneering studies on the structure and organization of nerve centers. Notably, in 1910, Cajal published a seminal work in which he described the essential components of the neuronal nucleus, primarily using his reduced sil...

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Autores: Lafarga, Miguel, Berciano, María T., Oriol Narcís, J., Calvo Baltanás, Fernando, Tapia, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/179928
Acceso en línea:https://hdl.handle.net/11441/179928
https://doi.org/10.3389/fnana.2025.1724830
Access Level:acceso abierto
Palabra clave:Cajal and neuronal nucleus
Nuclear condensates
Nucleolus
Nuclear speckles
Cajal body
Transcription factories
Nucleoskeleton
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spelling Cajal’s organization of neuronal nucleus revisitedLafarga, MiguelBerciano, María T.Oriol Narcís, J.Calvo Baltanás, FernandoTapia, OlgaCajal and neuronal nucleusNuclear condensatesNucleolusNuclear specklesCajal bodyTranscription factoriesNucleoskeletonIn 1906, Cajal was awarded the Nobel Prize in Physiology or Medicine for his pioneering studies on the structure and organization of nerve centers. Notably, in 1910, Cajal published a seminal work in which he described the essential components of the neuronal nucleus, primarily using his reduced silver nitrate procedure. Using modern microscopy techniques, we have identified the current equivalents of the structures originally described by Cajal. These include the “fibrillar center–dense fibrillar component units” of the nucleolus, “nuclear speckles,” “transcription factories,” and “the Cajal body.” Importantly, these structures represent key nuclear compartments involved in the transcription of rDNA and protein-coding genes, pre-rRNA and pre-mRNA processing and spatial genome organization. Most of the nuclear components described by Cajal are now recognized as dynamic “nuclear condensates” assembled through liquid–liquid phase separation mechanisms that depend on various categories of RNA and RNA-binding proteins.Frontiers Media, S. A.Fisiología Médica y BiofísicaInstituto de Biomedicina de Sevilla (IBIS)CTS007: Fisiopatología de Células Madre NeuralesMinisterio de Ciencia e Innovación (MICIN). España2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/179928https://doi.org/10.3389/fnana.2025.1724830reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Neuroanatomy, 19, 1724830.PID2021-126820OB-I00MCIN/AEI/10.13039/501100011033https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2025.1724830/fullinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1799282026-06-17T12:51:07Z
dc.title.none.fl_str_mv Cajal’s organization of neuronal nucleus revisited
title Cajal’s organization of neuronal nucleus revisited
spellingShingle Cajal’s organization of neuronal nucleus revisited
Lafarga, Miguel
Cajal and neuronal nucleus
Nuclear condensates
Nucleolus
Nuclear speckles
Cajal body
Transcription factories
Nucleoskeleton
title_short Cajal’s organization of neuronal nucleus revisited
title_full Cajal’s organization of neuronal nucleus revisited
title_fullStr Cajal’s organization of neuronal nucleus revisited
title_full_unstemmed Cajal’s organization of neuronal nucleus revisited
title_sort Cajal’s organization of neuronal nucleus revisited
dc.creator.none.fl_str_mv Lafarga, Miguel
Berciano, María T.
Oriol Narcís, J.
Calvo Baltanás, Fernando
Tapia, Olga
author Lafarga, Miguel
author_facet Lafarga, Miguel
Berciano, María T.
Oriol Narcís, J.
Calvo Baltanás, Fernando
Tapia, Olga
author_role author
author2 Berciano, María T.
Oriol Narcís, J.
Calvo Baltanás, Fernando
Tapia, Olga
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
Instituto de Biomedicina de Sevilla (IBIS)
CTS007: Fisiopatología de Células Madre Neurales
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv Cajal and neuronal nucleus
Nuclear condensates
Nucleolus
Nuclear speckles
Cajal body
Transcription factories
Nucleoskeleton
topic Cajal and neuronal nucleus
Nuclear condensates
Nucleolus
Nuclear speckles
Cajal body
Transcription factories
Nucleoskeleton
description In 1906, Cajal was awarded the Nobel Prize in Physiology or Medicine for his pioneering studies on the structure and organization of nerve centers. Notably, in 1910, Cajal published a seminal work in which he described the essential components of the neuronal nucleus, primarily using his reduced silver nitrate procedure. Using modern microscopy techniques, we have identified the current equivalents of the structures originally described by Cajal. These include the “fibrillar center–dense fibrillar component units” of the nucleolus, “nuclear speckles,” “transcription factories,” and “the Cajal body.” Importantly, these structures represent key nuclear compartments involved in the transcription of rDNA and protein-coding genes, pre-rRNA and pre-mRNA processing and spatial genome organization. Most of the nuclear components described by Cajal are now recognized as dynamic “nuclear condensates” assembled through liquid–liquid phase separation mechanisms that depend on various categories of RNA and RNA-binding proteins.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/179928
https://doi.org/10.3389/fnana.2025.1724830
url https://hdl.handle.net/11441/179928
https://doi.org/10.3389/fnana.2025.1724830
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Neuroanatomy, 19, 1724830.
PID2021-126820OB-I00
MCIN/AEI/10.13039/501100011033
https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2025.1724830/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media, S. A.
publisher.none.fl_str_mv Frontiers Media, S. A.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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