Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation

Background Anodal transcranial direct current stimulation (tDCS) of the somatosensory cortex causes cerebral hyperexcitability and a significant enhancement in pain thresholds and tactile spatial acuity. Sensory gating is a brain mechanism to suppress irrelevant incoming inputs, which is elicited by...

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Autores: Montoro, Casandra, I, Winterholler, Christine, Terrasa, Juan Lorenzo, Montoya, Pedro
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19826
Acceso en línea:https://hdl.handle.net/20.500.13003/19826
Access Level:acceso abierto
Palabra clave:late positive complex
cortical excitability
sensory gating
somatosensory cortex
transcranial direct current stimulation
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spelling Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current StimulationMontoro, Casandra, IWinterholler, ChristineTerrasa, Juan LorenzoMontoya, Pedrolate positive complexcortical excitabilitysensory gatingsomatosensory cortextranscranial direct current stimulationBackground Anodal transcranial direct current stimulation (tDCS) of the somatosensory cortex causes cerebral hyperexcitability and a significant enhancement in pain thresholds and tactile spatial acuity. Sensory gating is a brain mechanism to suppress irrelevant incoming inputs, which is elicited by presenting pairs of identical stimuli (S1 and S2) within short time intervals between stimuli (e.g., 500 ms). Objectives/Hypothesis The present study addressed the question of whether tDCS could modulate the brain correlates of this inhibitory mechanism. Methods Forty-one healthy individuals aged 18-26 years participated in the study and were randomly assigned to tDCS (n = 21) or SHAM (n = 20). Somatosensory evoked potentials (SEP) elicited by S1 and S2 pneumatic stimuli (duration of 100 ms, ISI 550 +/- 50 ms) and applied to the index finger of the dominant hand were recorded before and after tDCS. Results Before the intervention, the second tactile stimuli significantly attenuated the amplitudes of P50, N100, and the late positive complex (LPC, mean amplitude in the time window 150-350) compared to the first stimuli. This confirmed that sensory gating is a widespread brain inhibitory mechanism that can affect early- and middle-latency components of SEPs. Furthermore, our data revealed that this response attenuation or sensory gating (computed as S1 minus S2) was improved after tDCS for LPC, while no changes were found in participants who received SHAM. Conclusion All these findings suggested that anodal tDCS might modulate brain excitability leading to an enhancement of inhibitory mechanisms elicited in response to repetitive somatosensory stimuli during late stages of information processing.Frontiers Media Sa20212021-09-0720212021-09-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19826reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/198262026-06-22T12:44:07Z
dc.title.none.fl_str_mv Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
title Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
spellingShingle Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
Montoro, Casandra, I
late positive complex
cortical excitability
sensory gating
somatosensory cortex
transcranial direct current stimulation
title_short Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
title_full Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
title_fullStr Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
title_full_unstemmed Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
title_sort Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
dc.creator.none.fl_str_mv Montoro, Casandra, I
Winterholler, Christine
Terrasa, Juan Lorenzo
Montoya, Pedro
author Montoro, Casandra, I
author_facet Montoro, Casandra, I
Winterholler, Christine
Terrasa, Juan Lorenzo
Montoya, Pedro
author_role author
author2 Winterholler, Christine
Terrasa, Juan Lorenzo
Montoya, Pedro
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv late positive complex
cortical excitability
sensory gating
somatosensory cortex
transcranial direct current stimulation
topic late positive complex
cortical excitability
sensory gating
somatosensory cortex
transcranial direct current stimulation
description Background Anodal transcranial direct current stimulation (tDCS) of the somatosensory cortex causes cerebral hyperexcitability and a significant enhancement in pain thresholds and tactile spatial acuity. Sensory gating is a brain mechanism to suppress irrelevant incoming inputs, which is elicited by presenting pairs of identical stimuli (S1 and S2) within short time intervals between stimuli (e.g., 500 ms). Objectives/Hypothesis The present study addressed the question of whether tDCS could modulate the brain correlates of this inhibitory mechanism. Methods Forty-one healthy individuals aged 18-26 years participated in the study and were randomly assigned to tDCS (n = 21) or SHAM (n = 20). Somatosensory evoked potentials (SEP) elicited by S1 and S2 pneumatic stimuli (duration of 100 ms, ISI 550 +/- 50 ms) and applied to the index finger of the dominant hand were recorded before and after tDCS. Results Before the intervention, the second tactile stimuli significantly attenuated the amplitudes of P50, N100, and the late positive complex (LPC, mean amplitude in the time window 150-350) compared to the first stimuli. This confirmed that sensory gating is a widespread brain inhibitory mechanism that can affect early- and middle-latency components of SEPs. Furthermore, our data revealed that this response attenuation or sensory gating (computed as S1 minus S2) was improved after tDCS for LPC, while no changes were found in participants who received SHAM. Conclusion All these findings suggested that anodal tDCS might modulate brain excitability leading to an enhancement of inhibitory mechanisms elicited in response to repetitive somatosensory stimuli during late stages of information processing.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-07
2021
2021-09-07
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19826
url https://hdl.handle.net/20.500.13003/19826
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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