Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study

Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort. Methods: A community-based sample recruited in 1995, 2000, and...

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Autores: Vilalta Lacarra, Anna, Vilalta Franch, Joan, Serrano Sarbosa, Domènec, Martí Lluch, Ruth, Marrugat, Jaume, Garre Olmo, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/27488
Acceso en línea:http://hdl.handle.net/10256/27488
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Depression, Mental
Càncer -- Mortalitat
Cancer -- Mortality
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spelling Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort studyVilalta Lacarra, AnnaVilalta Franch, JoanSerrano Sarbosa, DomènecMartí Lluch, RuthMarrugat, JaumeGarre Olmo, JosepDepressió psíquicaDepression, MentalCàncer -- MortalitatCancer -- MortalityObjective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort. Methods: A community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality. Results: The cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11–4.44) and women (HR = 3.69; 95% CI = 1.69–8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46–3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10–6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76–4.90) only in the male population. Conclusion: C-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.This study was supported by the research grant STL006/17/00234 from the Strategic Plan for Health Research and Innovation (PERIS) 2016–2020 of the Department of Health, Government of CataloniaFrontiers Media2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/27488http://hdl.handle.net/10256/27488Frontiers in Psychology, 2023, vol. 14, art. núm. 1192462Articles publicats (D-CM)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fpsyg.2023.1192462info:eu-repo/semantics/altIdentifier/eissn/1664-1078Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/274882026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
title Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
spellingShingle Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
Vilalta Lacarra, Anna
Depressió psíquica
Depression, Mental
Càncer -- Mortalitat
Cancer -- Mortality
title_short Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
title_full Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
title_fullStr Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
title_full_unstemmed Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
title_sort Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
dc.creator.none.fl_str_mv Vilalta Lacarra, Anna
Vilalta Franch, Joan
Serrano Sarbosa, Domènec
Martí Lluch, Ruth
Marrugat, Jaume
Garre Olmo, Josep
author Vilalta Lacarra, Anna
author_facet Vilalta Lacarra, Anna
Vilalta Franch, Joan
Serrano Sarbosa, Domènec
Martí Lluch, Ruth
Marrugat, Jaume
Garre Olmo, Josep
author_role author
author2 Vilalta Franch, Joan
Serrano Sarbosa, Domènec
Martí Lluch, Ruth
Marrugat, Jaume
Garre Olmo, Josep
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Depression, Mental
Càncer -- Mortalitat
Cancer -- Mortality
topic Depressió psíquica
Depression, Mental
Càncer -- Mortalitat
Cancer -- Mortality
description Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort. Methods: A community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality. Results: The cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11–4.44) and women (HR = 3.69; 95% CI = 1.69–8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46–3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10–6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76–4.90) only in the male population. Conclusion: C-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/27488
http://hdl.handle.net/10256/27488
url http://hdl.handle.net/10256/27488
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fpsyg.2023.1192462
info:eu-repo/semantics/altIdentifier/eissn/1664-1078
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Frontiers in Psychology, 2023, vol. 14, art. núm. 1192462
Articles publicats (D-CM)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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