Permeation Protection by Waterproofing Mucosal Membranes

The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the barri...

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Detalles Bibliográficos
Autores: Coderch Negra, M. Luisa, Alonso, Cristina, Calpena, Ana Cristina, Pérez-García, Maria Luisa, Clares-Naveros, Beatriz, Ramos, Anderson, Martí, Meritxell
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341828
Acceso en línea:http://hdl.handle.net/10261/341828
https://api.elsevier.com/content/abstract/scopus_id/85180732765
Access Level:acceso abierto
Palabra clave:Protection
Kinetic permeation
Mucosa
Permeability
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Permeation Protection by Waterproofing Mucosal MembranesCoderch Negra, M. LuisaAlonso, CristinaCalpena, Ana CristinaPérez-García, Maria LuisaClares-Naveros, BeatrizRamos, AndersonMartí, MeritxellProtectionKinetic permeationMucosaPermeabilityhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesThe permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane water loss of different formulations was evaluated, and three of them were selected to be tested on the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of the formulations. A similar permeation profile was obtained in the different membranes: caffeine > ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation composed of lipids that are present in the skin stratum corneum. Impermeability provided by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa provides a reduction or prevention of the permeation of different actives, which could be extrapolated to toxic compounds such as viruses, contaminants, toxins, etc.This work was supported by the Consejo Superior de Investigaciones Científicas “Modificación de la mucosa como protección frente al SARS-CoV-2” (CSIC-COV19-130).Peer reviewedMultidisciplinary Digital Publishing Institute0000-0001-9496-66470000-0002-4989-48210000-0001-6126-78900000-0001-9681-6466Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/341828https://api.elsevier.com/content/abstract/scopus_id/85180732765reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPharmaceuticshttps://doi.org/10.3390/pharmaceutics15122698Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3418282026-05-22T06:33:51Z
dc.title.none.fl_str_mv Permeation Protection by Waterproofing Mucosal Membranes
title Permeation Protection by Waterproofing Mucosal Membranes
spellingShingle Permeation Protection by Waterproofing Mucosal Membranes
Coderch Negra, M. Luisa
Protection
Kinetic permeation
Mucosa
Permeability
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Permeation Protection by Waterproofing Mucosal Membranes
title_full Permeation Protection by Waterproofing Mucosal Membranes
title_fullStr Permeation Protection by Waterproofing Mucosal Membranes
title_full_unstemmed Permeation Protection by Waterproofing Mucosal Membranes
title_sort Permeation Protection by Waterproofing Mucosal Membranes
dc.creator.none.fl_str_mv Coderch Negra, M. Luisa
Alonso, Cristina
Calpena, Ana Cristina
Pérez-García, Maria Luisa
Clares-Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author Coderch Negra, M. Luisa
author_facet Coderch Negra, M. Luisa
Alonso, Cristina
Calpena, Ana Cristina
Pérez-García, Maria Luisa
Clares-Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author_role author
author2 Alonso, Cristina
Calpena, Ana Cristina
Pérez-García, Maria Luisa
Clares-Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0001-9496-6647
0000-0002-4989-4821
0000-0001-6126-7890
0000-0001-9681-6466
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Protection
Kinetic permeation
Mucosa
Permeability
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Protection
Kinetic permeation
Mucosa
Permeability
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane water loss of different formulations was evaluated, and three of them were selected to be tested on the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of the formulations. A similar permeation profile was obtained in the different membranes: caffeine > ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation composed of lipids that are present in the skin stratum corneum. Impermeability provided by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa provides a reduction or prevention of the permeation of different actives, which could be extrapolated to toxic compounds such as viruses, contaminants, toxins, etc.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341828
https://api.elsevier.com/content/abstract/scopus_id/85180732765
url http://hdl.handle.net/10261/341828
https://api.elsevier.com/content/abstract/scopus_id/85180732765
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pharmaceutics
https://doi.org/10.3390/pharmaceutics15122698
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413534445600768
score 15.811543

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