Azacitidine vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the PETHEMA Registry

Simple Summary The use of azacitidine (AZA) and decitabine (DEC) have allowed more elderly acute myeloid leukemia (AML) patients to be treated. However, scarcely any direct comparative data exist between both drugs. This study shows no significant differences in response rates or overall survival (O...

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Detalhes bibliográficos
Autores: Labrador, J, Martinez-Cuadron, D, de la Fuente, A, Rodriguez-Veiga, R, Serrano, J, Tormo, M, Rodriguez-Arboli, E, Ramos, F, Bernal, T, Lopez-Pavia, M, Trigo, F, Martinez-Sanchez, MP, Rodriguez-Gutierrez, JI, Rodriguez-Medina, C, Gil, C, Belmonte, DG, Vives, S, Foncillas, MA, Perez-Encinas, M, Novo, A, Recio, I, Rodriguez-Macias, G, Bergua, JM, Noriega, V, Lavilla, E, Roldan-Perez, A, Sanz, MA, Montesinos, P
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8952
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones8952
Access Level:acceso abierto
Palavra-chave:acute myeloid leukemia
elderly
treatment
azacitidine
decitabine
hypomethylating agents
PETHEMA
Descrição
Resumo:Simple Summary The use of azacitidine (AZA) and decitabine (DEC) have allowed more elderly acute myeloid leukemia (AML) patients to be treated. However, scarcely any direct comparative data exist between both drugs. This study shows no significant differences in response rates or overall survival (OS) between upfront AZA and DEC treatment in a large retrospective with long-term follow-up cohort of AML patients. However, we identified for the first time the baseline characteristics of patients benefitting from AZA vs. DEC in terms of responses, 120-day mortality and OS. We also show differences in salvage treatment patterns and outcomes after failure to both hypomethylating agents in a real-life setting. Taken together, these findings could help to select the most appropriate hypomethylating agent in monotherapy. The hypomethylating agents, decitabine (DEC) and azacitidine (AZA), allowed more elderly acute myeloid leukemia (AML) patients to be treated. However, there are little direct comparative data on AZA and DEC. This multicenter retrospective study compared the outcomes of AZA and DEC in terms of response and overall survival (OS). Potential predictors associated with response and OS were also evaluated. A total of 626 AML patients were included (487 treated with AZA and 139 with DEC). Response rates were similar in both groups: CR was 18% with AZA vs. 23% with DEC (p = 0.20), CR/CRi was 20.5% vs. 25% (p = 0.27) and ORR was 32% vs. 39.5% (p = 0.12), respectively. Patients with leukocytes < 10 x 10(9)/L, bone marrow blasts < 50% and ECOG >= 2 had higher ORR with DEC than with AZA. OS was similar in both groups: 10.4 months (95% CI: 9.2-11.7) vs. 8.8 months (95% CI: 6.7-11.0, p = 0.455), for AZA and DEC, respectively. Age (>= 80 years), leukocytes (>= 10 x 10(9)/L), platelet count (<20 x 10(9)/L) and eGFR (>= 45 mL/min/1.73 m(2)) were associated with higher OS with AZA compared to DEC. In conclusion, we found no differences in response and OS rates in AML patients treated with AZA or DEC.

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